Patents by Inventor Robert Greenhouse

Robert Greenhouse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SMALL MOLECULE INHIBITORS OF G PROTEIN COUPLED RECEPTOR 6 KINASE POLYPEPTIDES
    Publication number: 20170050939
    Abstract: This document relates to inhibitors of G protein coupled receptor 6 kinase (GRK6) polypeptides as well as methods and materials for using such inhibitors to treat hematological malignancies, inflammation diseases, and autoimmune disorders.
    Type: Application
    Filed: April 21, 2015
    Publication date: February 23, 2017
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Alexander Keith Stewart, Robert Greenhouse, Brian Rich, William Thomas, Nikolai Sepetov
  • SMALL MOLECULE INHIBITORS OF G PROTEIN COUPLED RECEPTOR 6 KINASES POLYPEPTIDES
    Publication number: 20170050979
    Abstract: This document relates to inhibitors of G protein coupled receptor 6 kinase (GRK6) polypeptides as well as methods and materials for using such inhibitors to treat hematological malignancies, inflammation diseases, and autoimmune disorders.
    Type: Application
    Filed: April 21, 2015
    Publication date: February 23, 2017
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Alexander Keith Stewart, Brian Rich, Nikolai Sepetov, Robert Greenhouse, Artem Plekhov, Wen Yang, Zhiwei Tong
  • SUBSTITUTED BENZOXAZINE AND RELATED COMPOUNDS
    Publication number: 20160326123
    Abstract: The present invention relates to compounds including but not limited to of any one of formulas Ia, Ib, IIa, IIb, IIIa, IIIb, and IV to VI, VIIa, VIIb, VIIIa, VIIIb and VIIIc as described herein and their tautomers and/or pharmaceutically acceptable salts, compositions, and methods of uses thereof.
    Type: Application
    Filed: January 8, 2015
    Publication date: November 10, 2016
    Applicant: THE J. DAVID GLADSTONE INSTITUTES, A TESTAMENTARY TRUST ESTABLISHED UNDER THE WILL OF J. DAVID GLAD
    Inventors: Andrey S. Tsvetkov, Steven M. Finkbeiner, Michael A. Pleiss, Robert Greenhouse
  • TETRALIN AND INDANE DERIVATIVES AND USES THEREOF
    Publication number: 20150266817
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, p, q, Ar, R1 and R2 are as defined herein. Also provided are methods for preparing, compositions comprising, and methods for using compounds of formula I.
    Type: Application
    Filed: November 3, 2014
    Publication date: September 24, 2015
    Applicant: ROCHE PALO ALTO LLC
    Inventors: Robert Greenhouse, Ralph New Harris, III, Saul Jaime-Figueroa, James M. Kress, David Bruce Repke, Russell Stephen Stabler
  • Tetralin and indane derivatives and uses thereof
    Patent number: 8889906
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, p, q, Ar, R1 and R2 are as defined herein. Also provided are methods for preparing, compositions comprising, and methods for using compounds of formula I.
    Type: Grant
    Filed: December 8, 2011
    Date of Patent: November 18, 2014
    Assignee: Roche Palo Alto LLC
    Inventors: Robert Greenhouse, Ralph New Harris, III, Saul Jaime-Figueroa, James M. Kress, David Bruce Repke, Russell Stephen Stabler
  • Inhibiting G Protein Coupled Receptor 6 Kinase Polypeptides
    Publication number: 20140309185
    Abstract: This document relates to inhibitors of G protein coupled receptor 6 kinase (GRK6) polypeptides as well as methods and materials for using such inhibitors to treat hematological malignancies, inflammation diseases, and autoimmune disorders.
    Type: Application
    Filed: October 26, 2012
    Publication date: October 16, 2014
    Inventors: Alexander Keith Stewart, Artem Plekhov, Robert Greenhouse
  • TETRALIN AND INDANE DERIVATIVES AND USES THEREOF
    Publication number: 20120088837
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, p, q, Ar, R1 and R2 are as defined herein. Also provided are methods for preparing, compositions comprising, and methods for using compounds of formula I.
    Type: Application
    Filed: December 8, 2011
    Publication date: April 12, 2012
    Inventors: Robert Greenhouse, Ralph New Harris, III, Saul Jaime-Figueroa, James M. Kress, David Bruce Repke, Russell Stephen Stabler
  • Tetralin and indane derivatives and uses thereof
    Patent number: 8093424
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, p, q, Ar, R1 and R2 are as defined herein. Also provided are methods for preparing, compositions comprising, and methods for using compounds of formula I.
    Type: Grant
    Filed: November 15, 2007
    Date of Patent: January 10, 2012
    Assignee: Roche Palo Alto LLC
    Inventors: Robert Greenhouse, Ralph New Harris, III, Saul Jaime-Figueroa, James M. Kress, David Bruce Repke, Russell Stephen Stabler
  • IMIDAZOLINYLMETHYL ARYL SULFONAMIDE
    Publication number: 20110230535
    Abstract: This invention relates to an alpha-1A receptor partial agonist, which is represented by Formula I: and pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing formula I, methods for their use as therapeutic agents, and methods of preparation thereof.
    Type: Application
    Filed: June 3, 2011
    Publication date: September 22, 2011
    Inventors: Counde O'Yang, Robert Greenhouse
  • 3-amino-1-arylpropyl indoles as monoamine reuptake inhibitors
    Patent number: 7863305
    Abstract: Compounds of formula I: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein p, Ar, R1, R2, R3, Ra, Rb, Rc, Rd and Re are defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.
    Type: Grant
    Filed: June 1, 2005
    Date of Patent: January 4, 2011
    Assignee: Roche Palo Alto LLC
    Inventors: Robert Greenhouse, Saul Jaime-Figueroa, Lubica Raptova, Deborah Carol Reuter, Karin Ann Stein, Robert Weikert
  • Imidazolinylmethyl aryl sulfonamide
    Patent number: 7799816
    Abstract: This invention relates to an alpha-1 A receptor partial agonist, which is represented by Formula I: and pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing formula I, methods for their use as therapeutic agents, and methods of preparation thereof.
    Type: Grant
    Filed: February 4, 2009
    Date of Patent: September 21, 2010
    Assignee: Roche Palo Alto LLC
    Inventors: Counde O'Yang, Robert Greenhouse
  • 3-AMINO-1-ARYLPROPYL AZAINDOLES AND USES THEREOF
    Publication number: 20100056499
    Abstract: The present invention provides compounds of the formula: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein p, Ar, R1, R2, R3, Ra, Rb, Rc, Rd and Re are defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.
    Type: Application
    Filed: November 16, 2009
    Publication date: March 4, 2010
    Inventors: Robert Greenhouse, Saul Jaime-Figueroa, Stephen M. Lynch, Lubica Raptova, Karin Ann Stein, Robert James Weikert
  • 3-Amino-1-arylpropyl azaindoles and uses thereof
    Patent number: 7638517
    Abstract: The present invention provides compounds of the formula: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein p, Ar, R1, R2, R3, Ra, Rb, Rc, Rd and Re are defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.
    Type: Grant
    Filed: November 29, 2006
    Date of Patent: December 29, 2009
    Assignee: Roche Palo Alto LLC
    Inventors: Robert Greenhouse, Saul Jaime-Figueroa, Stephen M. Lynch, Lubica Raptova, Karin Ann Stein, Robert James Weikert
  • IMIDAZOLINYLMETHY ARYL SULFONAMIDE
    Publication number: 20090197931
    Abstract: This invention relates to an alpha-1 A receptor partial agonist, which is represented by Formula I: and pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing formula I, methods for their use as therapeutic agents, and methods of preparation thereof.
    Type: Application
    Filed: February 4, 2009
    Publication date: August 6, 2009
    Inventors: Counde O'Yang, Robert Greenhouse
  • IMIDAZOLINYLMETHYL ARYL SULFONAMIDE
    Publication number: 20090197934
    Abstract: This invention relates to an alpha-1A receptor partial agonist, which is represented by Formula I: and pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing formula I, methods for their use as therapeutic agents, and methods of preparation thereof.
    Type: Application
    Filed: February 4, 2009
    Publication date: August 6, 2009
    Inventors: Counde O'Yang, Robert Greenhouse
  • Tetralin and indane derivatives and uses thereof
    Publication number: 20080293751
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, p, q, Ar, R1 and R2 are as defined herein. Also provided are methods for preparing, compositions comprising, and methods for using compounds of formula I.
    Type: Application
    Filed: November 15, 2007
    Publication date: November 27, 2008
    Inventors: Robert Greenhouse, Ralph New Harris, III, Saul Jaime-Figueroa, James M. Kress, David Bruce Repke, Russell Stephen Stabler
  • Tetralin and indane derivatives and uses thereof
    Patent number: 7312359
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, p, q, Ar, R1 and R2 are as defined herein. Also provided are methods for preparing, compositions comprising, and methods for using compounds of formula I.
    Type: Grant
    Filed: December 21, 2005
    Date of Patent: December 25, 2007
    Assignee: Roche Palo Alto LLC
    Inventors: Robert Greenhouse, Ralph New Harris, III, Saul Jaime-Figueroa, James M. Kress, David Bruce Repke, Russell Stephen Stabler
  • 3-Amino-1-arylpropyl azaindoles and uses thereof
    Publication number: 20070123535
    Abstract: The present invention provides compounds of the formula: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein p, Ar, R1, R2, R3, Ra, Rb, Rc, Rd and Re are defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.
    Type: Application
    Filed: November 29, 2006
    Publication date: May 31, 2007
    Inventors: Robert Greenhouse, Saul Jamie-Figueroa, Stephen Lynch, Lubica Raptova, Karin Stein, Robert Weikert
  • Tetralin and indane derivatives and uses thereof
    Publication number: 20060167255
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, p, q, Ar, R1 and R2 are as defined herein. Also provided are methods for preparing, compositions comprising, and methods for using compounds of formula I.
    Type: Application
    Filed: December 21, 2005
    Publication date: July 27, 2006
    Inventors: Robert Greenhouse, Ralph Harris, Saul Jaime-Figueroa, James Kress, David Repke, Russell Stabler
  • 3-amino-1-arylpropyl indoles as monoamine reuptake inhibitors
    Publication number: 20060025467
    Abstract: Compounds of formula I: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein p, Ar, R1, R2, R3, Ra, Rb, Rc, Rd and Re are defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.
    Type: Application
    Filed: June 1, 2005
    Publication date: February 2, 2006
    Inventors: Robert Greenhouse, Saul-Jaime Figueroa, Lubica Raptova, Deborah Reuter, Karin Stein, Robert Weikert