Abstract: Octahydro-pyrrolo[3,4-b]pyrrole derivatives are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands, Octahydro-pyrrolo[3,4-b]pyrrole compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein.

Abstract: The present invention relates to the use of selective P2X7 receptor antagonists of formula I, or a pharmaceutically acceptable salt or prodrug thereof wherein D, R1 and R2 are as defined in claim 1, for the treatment of neuropathic pain, chronic inflammatory pain, inflammation, neurodegeneration and for promoting neuroregeneration,

Abstract: A wing having a transition region forming a blended, aerodynamic transition between inner and outer regions of the wing. The blended transition region does not include any planform breaks at the leading and trailing edges, where conventional wings would have such planform breaks. This allows the wing to be manufactured without significant forming and/or shot-peening operations to conform the skin of the wing to the planform breaks. Thus, the wing of the present invention can be manufactured with less cost and in less time, and provide even better aerodynamics than conventional aircraft wings. The wing of the present invention is further suitable for use on aircraft or aerospace vehicles, or any airborne vehicle requiring one or more aerodynamic airfoils or wing-like structures.

Abstract: Compounds of the present invention modulate PN3 in mammals and are useful in treating pain in mammals.

Abstract: A mobile platform lift increasing system includes at least one wing-shaped structure having a leading edge, a trailing edge and a chord length perpendicularly measurable between the leading and trailing edges. A rotatable control surface is located near a trailing edge undersurface. The control surface length is approximately one to five percent of the chord length. A deployment device is positioned between the wing shaped structure and the control surface. The deployment device operably rotates the control surface through a plurality of positions ranging between an initial position and a fully deployed position. Wing lift is increased at speeds up to approximately transonic speed by continuously rotating the control surface to accommodate variables including mobile platform weight change from fuel usage.