Abstract: The present invention pertains to cannabinoid (CB) receptor neutral antagonists, and especially CB1 neutral antagonists, and including, for example, certain 1,5-di-aryl-pyrazole compounds.

Abstract: The present invention relates to a process, a treatment solution and the product resulting from the process, which extends the shelf life of edible plant structures. The exposed edible plant structure is treated by applying a treatment solution to a comprising at least one antioxidant, at least one mineral salt, at least one organic acid and water; in a manner which impregnates the treatment solution into the exposed edible plant structure. This produces a treated edible plant structure having an extended shelf life. Preferably, the treated edible plant structure is thereafter sealed within a container containing a negligible amount of oxygen. The process of the present invention results in a treated edible plant structure which can be stored for relatively long periods of time, in comparison with untreated edible plant structures, without substantially deteriorating.

Abstract: The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain 2?,4?-dichloro-biphenyl-4-yl-hydroxy-ketones and related compounds (collectively referred to herein as “DCBP compounds”), and more particularly to compounds selected from compounds of the following formula and pharmaceutically acceptable salts, solvates, and hydrates thereof: wherein: n is independently 1, 2, 3, or 4; W is independently —C(?O)—, —CH(OH)—, or —C(?NOROX)—; ROX is independently —H or C1-3alkyl; J is independently: —H, —RE1, —C(?O)—RE2, —C(?O)—O—RE3, —C(?O)—O—S(?O)2ORE4, —C(?O)—(CH2)n—C(?O)ORE5, —C(?O)—(CH2)n—NRNE1RNE2, —C(?O)—(CH2)n—NRNE3—C(?O)RE6, —C(?O)—(CH2)n—C(?O)—NRNE4RNE5, or —P(?O)(ORE7)(ORE8); wherein each of RE1, RE2, RE3, RE4, RE5, RE6, and RE7 is independently: —H, C1-3alkyl, -Ph, or —CH2-Ph.

Abstract: In a loan option system having a loan server accessible through a network to an external borrower computer and a loan processor for providing loan parameters to the loan server, systems and methods are provided for determining and adjusting a loan balance, via (1) receiving a principal value for a loan through the network from the borrower computer, the principal value corresponding to the loan balance, wherein the loan has an interest rate and a loan term corresponding to a specified number of payments throughout the loan, (2) upon a permissible omitted payment, increasing the interest rate, determining accrued interest, setting predetermined fees due to the missed payment, and applying the predetermined fees and accrued interest to the loan balance to produce a new balance, (3) retrieving the new balance from the loan processor to the loan server, and (4) providing the new balance to the borrower computer.

Abstract: The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain 2?,4?-dichloro-biphenyl-4-yl-hydroxy-ketones and related compounds (collectively referred to herein as “DCBP compounds”), and more particularly to compounds selected from compounds of the following formula and pharmaceutically acceptable salts, solvates, and hydrates thereof: wherein: n is independently 1, 2, 3, or 4; W is independently —C(?O)—, —CH(OH)—, or —C(?NOROX)—; ROX is independently —H or C1-3alkyl; J is independently: —H, —RE1, —C(?O)—RE2, —C(?O)—O—RE3, —C(?O)—O—S(?O)2ORE4, —C(?O)—(CH2)n—C(?O)ORE5, —C(?O)—(CH2)n—NRNE1RNE2, —C(?O)—(CH2)n—NRNE3—C(?O)RE6, —C(?O)—(CH2)n—C(?O)—NRNE4RNE5, or —P(?O)(ORE7)(ORE8); wherein each of RE1, RE2, RE3, RE4, RE5, RE6, and RE7 is independently: —H, C1-3alkyl, -Ph, or —CH2-Ph.

Abstract: The present invention pertains to certain aryl alkyl sulfonamides and derivatives thereof which, inter alia, inhibit osteoclast survival, formation, and/or activity; and/or inhibit bone resorption, and more particularly to compounds of the formula: wherein: Ar1 is independently C5-20aryl (e.g., biphenyl, phenanthryl, fluorenyl, or carbazolyl, most preferably biphenyl), and is optionally substituted; RN is independently —H, acyl, C5-20aryl-C1-7alkyl, C3-20heterocyclyl, or C1-7alkyl, and is optionally substituted; Ralk is a C2-10alkylene group, and is optionally substituted; and Q is independently —H or an organic group having from 1 to 30 atoms selected from carbon, nitrogen, oxygen, sulfur, phosphorus, fluorine, chlorine, bromine, and iodine (e.g., an oxy-type group, an amine-type group, etc.); and pharmaceutically acceptable salts, solvates, amides, esters, ethers, chemically protected forms, and prodrugs thereof.

Abstract: An apparatus for densifying and transporting bulk materials, the apparatus comprising a container for holding bulk materials, a wheeled chassis for transporting the container along a roadway, and a shaker, mounted on the chassis and transportable therewith, for shaking the container while the container is being loaded, to increase packing density of bulk materials in the container. A related transportation system and methods are also provided.

Abstract: A system and program or method embodiment in a computer readable medium for monitoring a loan option program wherein the borrower has one of several options for omitting without penalty one or more installment payments, either on a fixed schedule or on a variable schedule. The basic method comprises a determination of the loan parameters without options; determining the type of loan option and revising the loan parameters in accordance therewith, determining interest change, if any, after an omitted payment; determining balance change after omitted payment; determining change in term of loan, if any, after omitted payment; and recalculating new payment schedule under changed parameters.

Abstract: The present invention relates to a process, a treatment solution and the product resulting from the process, which extends the shelf life of edible plant structures. The exposed edible plant structure is treated by applying a treatment solution to a comprising at least one antioxidant, at least one mineral salt, at least one organic acid and water; in a manner which impregnates the treatment solution into the exposed edible plant structure. This produces a treated edible plant structure having an extended shelf life. Preferably, the treated edible plant structure is thereafter sealed within a container containing a negligible amount of oxygen. The process of the present invention results in a treated edible plant structure which can be stored for relatively long periods of time, in comparison with untreated edible plant structures, without substantially deteriorating.