Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.

Abstract: Methods and compositions for preventing or reducing hair frizz. The compositions are anhydrous and comprise at least one polysiloxane fluid component selected from an amodimethicone and a polysiloxane component comprising a plurality of hindered amine side chains. The compositions also comprise a silicone-compatible, volatile liquid carrier component, preferably selected from a low molecular weight, volatile siloxy component; a hydrocarbon; and an alcohol. The compositions are preferably serums or fluids, and are suitable for use in a conditioner, as a “leave-in” hair care product, or as a touch-up hair care product suitable for use during the day.

Abstract: Methods and compositions for preventing or reducing hair frizz. The compositions are anhydrous and comprise at least one polysiloxane fluid component selected from an amodimethicon e and a polysiloxane component comprising a plurality of hindered amine side chains. The compositions also comprise a silicone-compatible, volatile liquid carrier component, preferably selected from a low molecular weight, volatile siloxy component; a hydrocarbon; and an alcohol. The compositions are preferably serums or fluids, and are suitable for use in a conditioner, as a “leave-in” hair care product, or as a touch-up hair care product suitable for use during the day.

Abstract: A system reproduces aerodynamic boundary layer transition conditions in a wind tunnel test environment under ambient to cryogenic temperature conditions. The system includes a test component disposed in the test environment that defines an exterior surface. A trip dot is mounted on the test component and has a first state, in which a distal surface of the trip dot is at a first elevation relative to the exterior surface of the test component, and a second state, in which the distal surface of the trip dot is at a second elevation relative to the exterior surface of the test component. An actuator is operably coupled to the trip dot and configured to transition the trip dot between first and second states. A controller remotely causes the actuator to transition the trip dot between the first and second states.

Abstract: A latching mechanism selectively joins two surfaces and/or objects and includes a latch and a catch. The latch includes a pivoting locking member with respect to the latch that pivots between a locked position and an unlocked position. First and second electromagnetic coils housed within the latch are selectively energized to cause pivotal movement of the locking member. The catch defines at least one pocket for receiving a portion of the locking member when the locking member is in the locked position and the latch and the catch are engaged.

Abstract: A system reproduces aerodynamic boundary layer transition conditions in a wind tunnel test environment under ambient to cryogenic temperature conditions. The system includes a test component disposed in the test environment that defines an exterior surface. A trip dot is mounted on the test component and has a first state, in which a distal surface of the trip dot is at a first elevation relative to the exterior surface of the test component, and a second state, in which the distal surface of the trip dot is at a second elevation relative to the exterior surface of the test component. An actuator is operably coupled to the trip dot and configured to transition the trip dot between first and second states. A controller remotely causes the actuator to transition the trip dot between the first and second states.

Abstract: A latching mechanism selectively joins two surfaces and/or objects and includes a latch and a catch. The latch includes a pivoting locking member with respect to the latch that pivots between a locked position and an unlocked position. An electromagnetic coil housed within the latch is selectively energized to cause pivotal movement of the locking member. The catch defines at least one pocket for receiving a portion of the locking member when the locking member is in the locked position and the latch and the catch are engaged. The latching mechanism may be normally-locked, such that the energizing of the coil moves the locking member to the unlocked position, or normally-unlocked, with the energizing of the coil moving the locking member to the locked position.

Abstract: We disclose herein a wire guard that is used to keep wire and other debris from wrapping around the axles of landfill trash compactors, thereby reducing the chance of damage to these axles and sealing systems. The wire guard is comprised of multiple segments that are individually welded to the edge of the wheel wrapper. The individual segments are through hardened and are, therefore, resistant to wear. Furthermore, they may include an overhanging lip that protects the edge of the wheel wrapper. This device is an improvement to other existing wire guards.

Abstract: Methods and systems for providing educational and instructional programs to users through wireless and cellular technology is disclosed. The method is designed to be highly flexible to allow the user a broad range of course selections, instruction difficulty level, and format of the instruction provided to the user. In a preferred embodiment of the method, the core steps comprise (a) authorizing the subscriber information; (b) identifying the selected curriculum, grade level, and format for the requested instruction; (c) selecting an appropriate question; (d) transmitting the selected question to the subscriber's cellular device; (e) receiving the subscriber's answer to the transmitted question; (f) determining whether the subscriber's answer is correct; (g) advising the subscriber whether the transmitted answer was correct; (h) recording and tracking the subscriber's answers in a database and then repeating the selecting process, and updating and analyzing the subscriber's progress.

Abstract: A housing for a light fixture, and the light itself, is disclosed. The housing comprises an elongate body and a resilient member mountable in the body to retain at least one light emitting diode (LED) between the resilient member and the housing such that the or each LED is repositionable within the housing. The light includes at least one LED mounted in the housing.

Abstract: A housing for a light fixture, and the light itself, is disclosed. The housing comprises an elongate body and a resilient member mountable in the body to retain at least one light emitting diode (LED) between the resilient member and the housing such that the or each LED is repositionable within the housing. The light includes at least one LED mounted in the housing.

Abstract: A slimline cassette assembly for rotating a louvre blade connected therewith is disclosed. The cassette assembly is capable of fitment within the stile of a frame supporting a plurality of such cassettes and an array of louvre blades connected therewith. The cassette assembly has a body for receiving a pair of straight cut mitre gears therein. The gears are located relative each other so that rotation of a first one of the gears by means of a perpendicular spline shaft connected in axial alignment therewith and extending between corresponding first mitre gears of consecutive cassette assemblies, causes rotation of the other second gear in each cassette assembly about ˜n axis perpendicular to the axis of each first gear. Rotation of the perpendicular shaft is thus imparted uniformly to the array of louvre blades connected in axial alignment with each of the respective second gears of the cassette assemblies.

Abstract: A boss (30) for use in a shutter having blades, the boss including an axial pin about which the boss is adapted to rotate, a complementary surface adapted to engage a translating member such as a toothed rack, a bearing surface adapted to rest in or on a support in the shutter assembly and blade engaging means (48). A shutter assembly and blade configuration are also disclosed.