Abstract: The present invention relates to the use of isomerization inhibitors in olefin metathesis reactions. The inhibitors are low molecular weight organic acids such as formic acid, acetic acid, benzoic acid, and the like.

Abstract: The present invention provides engineered proteins and biomedical products made from the engineered proteins. The biomedical products include lenses useful for ophthalmic purposes.

Abstract: The invention relates to a method of customizing lenses using an external stimulus such as light. Fine-tuning of the lens to match the precise optical requirements using the same lens is also possible. The lenses are self-contained and do not require the addition or removal of significant portions of the lens to achieve customization.

Abstract: The present invention relates to telechelic polymers having crosslinkable end groups of the formula and methods for preparing the same wherein n is an integer; is an alkadienyl group; Y is an alkyl group; and Z is crosslinkable end group. In general, the inventive synthesis involves reacting a functionalized chain transfer agent having crosslinkable ends with a cycloalkene in the presence of a ruthenium or osmium catalyst of the formula wherein: M is ruthenium or osmium; X and X1 are independently any anionic ligand; L and L1 are any neutral electron donor ligand; R and R1 are each hydrogen or a substituted or unsubstituted substituent wherein the substituent is selected from the group consisting of C1-C20 alkyl, C2-C20 alkenyl, C2-C20 alkynyl, aryl, C1-C20 carboxylate, C1-C20 alkoxy, C1-C20 alkenyloxy, C2-C20 alkynyloxy, aryloxy, C2-C20 alkoxycarbonyl, C1-C20 alkylthio, C1-C20 alkylsulfonyl and C1-C20 alkylsulfinyl.

Abstract: Provided are sensors, sensor arrays, and systems for detecting an analyte. A sensor provided by the disclosure comprises an amine-containing material. Such sensors are useful to detect carboxylic-containing analytes such as fatty acids.

Abstract: Ruthenium and osmium carbens compounds that are stable in the presence of a variety of functional groups and can be used to catalyze olefin metathesis reactions on unstrained cyclic and acyclic olefins are disclosed. Also disclosed are methods of making the carbene compounds. The carbene compounds are of the formula where M is Os or Ru; R1 is hydrogen; R is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, and substituted or unsubstituted aryl; X and X1 are independently selected from any anionic ligand; and L and L1 are independently selected from any neutral electron donor. The ruthenium and osmium carbene compounds of the present invention may be synthesized using diazo compounds, by neutral electron donor ligand exchange, by cross metathesis, using acetylene, using cumulated olefins, and in a one-pot method using diazo compounds and neutral electron donors.

Abstract: The present invention relates to altering the physical and/or chemical properties of at least part of at least one tissue in the eye. In a specific embodiment, it relates to the treatment of any eye disorder, although in particular embodiments the individual has a thickened Bruch's membrane. An activating energy source is utilized to effect a controlled diffusion enhancement and/or degradation of Bruch's membrane that enables improved diffusional transport between the choroid and retina. The individual is administered an inactivated diffusion-enhancing molecule that becomes associated with the membrane, which is then precisely exposed to an activating energy source, such as light or ultrasound.

Abstract: The invention relates to novel photoinitiators and their use in light adjustable compositions. The initiatives comprise two or more multiphoton chromophores linked by a bridging compound. The bridging compound consists of a material that is compatible with the base material of the light adjustable composition. The novel photoinitiator permit the readjustment of light adjustable material without the need for significant amounts of photoabsorbers.

Abstract: Methods and materials are disclosed for the production of optical elements, in particular intraocular lenses (IOL) that incorporate any amount (0 to 99%) of refraction and/or shape modulating compound into a substantially crosslinked first polymeric matrix. The materials produced according to the inventive methods exhibit certain rheological parameters useful in defining medical lenses. These medical lenses have the ability to change their refractive power via changing the refractive index and/or by altering the shape by stimulus induced polymerization.

Abstract: A method for synthesizing cyclic polymers using transition metal alkylidene complexes as reaction catalysts is provided, wherein the complexes contain a cyclic group. Polymerization is carried out on the catalyst, using cyclic olefin monomers that undergo ring insertion polymerization, and no linear intermediates are generated. Following completion of polymerization, the cyclic polymer detaches from the complex via an intramolecular chain transfer reaction and the catalytic complex is regenerated. The invention also provides novel transition metal alkylidene complexes useful as catalysts in the aforementioned process, as well as novel cyclic hydrocarbons.

Abstract: A prosthetic connector includes a cylindrical housing having a semi-toroidal top surface and a flat bottom surface with a mated pin receiving aperture extending axially therethrough and a diametrically positioned cavity therein. The flat bottom surface of the connector is mounted to a prosthetic. A shuttle lock latch is slidingly disposed in the cavity, and the connector includes a means for biasing the shuttle lock latch wherein a portion of latch is available to positively secure a mated pin inserted into the pin receiving aperture. The prosthesis includes an actuator means for releasing the pin. The shuttle lock latch is securable to the pin by engagement of the shuttle lock latch, and the connector is manually releasable by means of the actuator.

Abstract: A prosthetic connector includes a cylindrical housing having a semi-toroidal top surface and a flat bottom surface with a mated pin receiving aperture extending axially therethrough and a diametrically positioned cavity therein. The flat bottom surface of the connector is mounted to a prosthetic. A shuttle lock latch is slidingly disposed in the cavity, and the connector includes a means for biasing the shuttle lock latch wherein a portion of latch is available to positively secure a mated pin inserted into the pin receiving aperture. The prosthesis includes an actuator means for releasing the pin. The shuttle lock latch is securable to the pin by engagement of the shuttle lock latch, and the connector is manually releasable by means of the actuator.

Abstract: The present invention relates to telechelic polymers having crosslinkable end groups of the formula 1

Abstract: A method and apparatus for re-establising frequency, phase and amplitude coherence for radar samples generated by mutiple frequency transmitter pulse trains. A plurality of transmitter means 10-12 produce pulses of different frequencies and an antenna 22 and waveguide 24 direct the pulses 26 towards the aircraft 30. The reflected radar signal 32 returns to the antenna 22 l and waveguide 24 and is measured by the receiver 14. The reflected radar signal is then frequency rescaled, phase realigned, and amplitude normalized by the computer processor 18 and output to a processor/display unit 20.