Patents by Inventor Robert H Bradbury
Robert H Bradbury has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6593326Abstract: A pyrimidine derivative of formula (I): wherein: R1 is an optional substituent as defined within; Rx is selected from halo, hydroxy, nitro, amino, cyano, mercapto, carboxy, sulphamoyl, formamido, ureido or carbamoyl or a group of formula (Ib): A—B—C— as defined within; Q1 and Q2 are independently selected from aryl, a 5- or 6-membered monocyclic moiety; and a 9- or 10-membered bicyclic heterocyclic moiety; and one or both of Q1 and Q2 bears on any available carbon atom one substituent of formula (Ia) as defined within; and Q1 and Q2 are optionally further substituted; or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof; are useful as anti-cancer agents; and processes for their manufacture and pharmaceutical compositions containing them are described.Type: GrantFiled: August 23, 2001Date of Patent: July 15, 2003Assignee: AstraZeneca ABInventors: Robert H Bradbury, Gloria A Breault, Philip J Jewbury, Janet E Pease
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Patent number: 5387592Abstract: The invention concerns pharmaceutically useful compounds of the formula I, in which Q, X, Z and Ra have the various meanings defined herein, and their non-toxic salts, and pharmaceutical compositions containing them for treating conditions as hypertension and congestive heart failure.Type: GrantFiled: June 25, 1992Date of Patent: February 7, 1995Assignee: Imperial Chemical Industries PLCInventors: Robert H. Bradbury, Andrew P. Thomas
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Patent number: 5380730Abstract: The invention concerns pharmaceutically useful compounds of the formula I, in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, X and Z have the various meanings defined herein, and their non-toxic salts, and pharmaceutical compositions containing them. The novel compounds are of value in treating conditions such as hypertension and congestive heart failure. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment.Type: GrantFiled: June 14, 1993Date of Patent: January 10, 1995Assignee: Imperial Chemical Industries PLCInventors: David A. Roberts, Robert H. Bradbury, Martin P. Edwards, Arnold H. Ratcliffe
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Patent number: 5373015Abstract: The invention concerns pharmaceutically useful compounds of the formula I, in which Q, X, Z, G.sup.1, G.sup.2, G.sup.3 and G.sup.4 have the various meanings defined herein, and their non-toxic salts, and pharmaceutical compositions containing them. The novel compounds are of value in treating conditions such as hypertension and congestive heart failure.Type: GrantFiled: October 14, 1992Date of Patent: December 13, 1994Assignee: Imperial Chemical Industries PLCInventor: Robert H. Bradbury
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Patent number: 5369114Abstract: There are disclosed quinolines of the formula ##STR1## wherein R.sup.1 is hydrogen, or hydrocarbyl. R.sub.3 and R.sub.4 are independently, H, alkyl, various functional groups or alkylenedioxy, X is phenylene optionally bearing a substituent, R.sub.a is (1-4)C alkyl optionally bearing one or more F's, Z is various carboxyl derivatives, useful as angiotensin II antagonists.Type: GrantFiled: August 3, 1993Date of Patent: November 29, 1994Assignee: Imperial Chemical Industries PLCInventors: David A. Roberts, Robert J. Pearce, Robert H. Bradbury, Andrew P. Thomas
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Patent number: 5281613Abstract: The invention concerns pharmaceutically useful compounds of the formula I, in which Q, X, G.sup.1, Z and Ra have the various meanings defined herein, and their non-toxic salts, and pharmaceutical compositions containing them. The novel compounds are of value in treating conditions such as hypertension and congestive heart failure. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment.Type: GrantFiled: June 25, 1992Date of Patent: January 25, 1994Assignee: Imperial Chemical Industries PLCInventors: Robert H. Bradbury, Andrew P. Thomas
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Patent number: 5254679Abstract: A cephalosporin derivative of the formula I: ##STR1## in which X is S, O, CH.sub.2 or SO, ##STR2## represents one of C-7 acyl groups known in the cephalosporin art, R3 is hydrogen or methoxy, R4 is hydrogen, optionally substituted alkyl or allyl, and R5 is an aromatic heterocyclic ring system which is linked via carbon, and which contains a quaternized nitrogen atom.Type: GrantFiled: June 28, 1991Date of Patent: October 19, 1993Assignees: Imperial Chemical Industries PLC, ICI PharmaInventors: robert H. Bradbury, Frederic H. Jung, Jean J. Lohmann, Peter R. Marsham, Georges Pasquet
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Patent number: 5236937Abstract: The invention concerns pharmaceutically useful compounds of the formula I, in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, Rz, X and Z have the various meanings defined herein, and their non-toxic salts, and pharmaceutical compositions containing them. The novel compounds are of value in treating conditions such as hypertension and congestive heart failure. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment.Type: GrantFiled: February 11, 1992Date of Patent: August 17, 1993Assignee: Imperial Chemical Industries PLCInventors: Robert H. Bradbury, Martin P. Edwards, Arnold H. Ratcliffe
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Patent number: 5236936Abstract: The invention concerns pharmaceutically useful compounds of the formula I, in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, X and Z have the various meanings defined herein, and their non-toxic salts, and pharmaceutical compositions containing them. The novel compounds are of value in treating conditions such as hypertension and congestive heart failure. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment.Type: GrantFiled: February 11, 1992Date of Patent: August 17, 1993Assignee: Imperial Chemical Industries PLCInventors: David A. Roberts, Robert H. Bradbury, Martin P. Edwards, Arnold H. Ratcliffe
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Patent number: 5219863Abstract: The invention concerns pharmaceutically useful novel compounds of the formula I, in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, X, X.sup.1 and Z have the various meanings defined herein, and their non-toxic salts, and pharmaceutical compositions containing them. The novel compounds are of value in treating conditions such as hypertension and congestive heart failure. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment.Type: GrantFiled: November 14, 1991Date of Patent: June 15, 1993Assignee: Imperial Chemical Industries PLCInventors: David A. Roberts, Robert J. Pearce, Robert H. Bradbury
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Patent number: 5198434Abstract: The invention concerns pharmaceutically useful compounds of the formula I, in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, n, m, X, Y and Z have the various meanings defined herein, and their non-toxic salts, and pharmaceutical compositions containing them. The novel compounds are of value in treating conditions such as hypertension and congestive heart failure. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment.Type: GrantFiled: February 11, 1992Date of Patent: March 30, 1993Assignee: Imperial Chemical Industries PLCInventors: Robert H. Bradbury, David A. Roberts
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Patent number: 5198439Abstract: The invention concerns pharmaceutically useful novel compounds of the formula I, in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, X and Z have the various meanings defined herein, and their non-toxic salts, and pharmaceutical compositions containing them. The novel compounds are of value in treating conditions such as hypertension and congestive heart failure. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment.Type: GrantFiled: April 27, 1992Date of Patent: March 30, 1993Assignee: Imperial Chemical Industries PLCInventors: David A. Roberts, Arnold H. Ratcliffe, Robert H. Bradbury
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Patent number: 5130318Abstract: The invention concerns pharmaceutically useful novel compounds of the formula I, in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, X and Z have the various meanings defined herein, and their non-toxic salts, and pharmaceutical compositions containing them. The novel compounds are of value in treating conditions such as hypertension and congestive heart failure. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment.Type: GrantFiled: April 18, 1991Date of Patent: July 14, 1992Assignee: Imperial Chemical Industries PLCInventors: David A. Roberts, Arnold H. Ratcliffe, Robert H. Bradbury
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Patent number: 5126344Abstract: The invention concerns pharmaceutically useful novel compounds of the formula I, in which ring B, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, X and Z have the various meanings defined herein, and their non-toxic salts, and pharmaceutical compositions containing them. The novel compounds are of value in treating conditions such as hypertension and congestive heart failure. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment.Type: GrantFiled: November 19, 1990Date of Patent: June 30, 1992Assignee: Imperial Chemical Industries PLCInventors: David A. Roberts, Robert J. Pearce, Robert H. Bradbury, Richard W. A. Luke
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Patent number: 5091425Abstract: This invention concerns novel nitrogen derivatives of the formula I ##STR1## (and their pharmaceutically-acceptable salts), together with pharmaceutical compositions containing them. The nitrogen derivatives are inhibitors of the catalytic action of renin. The invention further concerns novel processes for the manufacture of said inhibitors.Type: GrantFiled: November 14, 1989Date of Patent: February 25, 1992Assignee: Imperial Chemical Industries plcInventors: Robert H. Bradbury, David Brown, David A. Roberts, David Waterson
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Patent number: 5049558Abstract: A cephalosporin derivative of the formula I: ##STR1## in which X is ##STR2## represents one of C-7 acyl groups known in the cephalosporin art, R3 is hydrogen or methoxy, R4 is hydrogen, optionally substituted alkyl or allyl, and R5 is an aromatic heterocyclic ring system which is linked via carbon, and which contains a quaternized nitrogen atom.Type: GrantFiled: September 19, 1989Date of Patent: September 17, 1991Assignees: Imperial Chemical Industries plc, ICI PharmaInventors: Robert H. Bradbury, Frederic H. Jung, Jean J. Lohmann, Peter R. Marsham, Georges Pasquet