Patents by Inventor Robert H. Chen

Robert H. Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Optimization and Mechanization of Periodic Flight
    Publication number: 20090177339
    Abstract: The implementation of periodic flight for enhancing aircraft's endurance or range is described having at least two components in the periodic flight embodiments. The first component is the trajectory optimization which determines the optimal periodic trajectory (such as altitude, velocity and flight path angle) that produces maximal endurance or range for a given fuel. The second component is the periodic guidance law which mechanizes the optimal periodic trajectory. For certain aircraft, periodic flight improves that aircraft's endurance or range over steady state flight.
    Type: Application
    Filed: January 16, 2009
    Publication date: July 9, 2009
    Inventors: Robert H. Chen, Jason L. Speyer
  • Homing missile guidance and estimation algorithms against advanced maneuvering targets
    Patent number: 7487933
    Abstract: A system, processing structure and method for performing vehicle intercept includes target acceleration estimation or blocking via a filter prior to deriving an interceptor acceleration time history via a guidance law. In the processing structure where the unknown target accelerations are blocked from affecting estimates, a guidance law is generated, stored and retrieved accounting for worst case target acceleration. In the processing structure where the target acceleration is presumed constant with a constant bank angle, the guidance law is closed form, exploiting constant heading angular velocity, and thus generated online.
    Type: Grant
    Filed: July 5, 2006
    Date of Patent: February 10, 2009
    Inventors: Robert H. Chen, Ashitosh Swarup, Jason Lee Speyer
  • Method for treating neurodegenerative disorders
    Patent number: 7018797
    Abstract: The invention is directed to a method of treating a neurodegenerative disorder in a subject in need thereof which comprises administering to the subject an amount of a compound effective to inhibit the interaction of amyloid-beta with alpha-7 nicotinic acetylcholine receptors.
    Type: Grant
    Filed: June 5, 2002
    Date of Patent: March 28, 2006
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Allen B. Reitz, David A. Demeter, Daniel H. S. Lee, Hoau-Yan Wang, Robert H. Chen, Tina Morgan Ross, Malcolm K. Scott, Carlos R. Plata-Salaman
  • Cyclobutene derivatives useful as antagonists of the motilin receptor
    Patent number: 6667309
    Abstract: The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.
    Type: Grant
    Filed: March 12, 2002
    Date of Patent: December 23, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Robert H. Chen, Min A. Xiang
  • Cyclopentene derivatives useful as antagonists of the motilin receptor
    Patent number: 6624165
    Abstract: The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.
    Type: Grant
    Filed: April 9, 2002
    Date of Patent: September 23, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Robert H. Chen, Min A. Xiang
  • Method for treating neurodegenerative disorders
    Publication number: 20030130165
    Abstract: The invention is directed to a method of treating a neurodegenerative disorder in a subject in need thereof which comprises administering to the subject an amount of a compound effective to inhibit the interaction of amyloid-beta with alpha-7 nicotinic acetylcholine receptors.
    Type: Application
    Filed: June 5, 2002
    Publication date: July 10, 2003
    Inventors: Allen B. Reitz, David A. Demeter, Daniel H.S. Lee, Hoau-Yan Wang, Robert H. Chen, Tina Morgan Ross, Malcolm K. Scott, Carlos R. Plata-Salaman
  • Method of treating neurodegenerative disorders via inhibition of amyloid beta peptide binding
    Patent number: 6441049
    Abstract: The invention is directed to a method of treating a neurodegenerative disorder in a subject in need thereof which comprises administering to the subject an amount of a compound effective to inhibit the interaction of amyloid-beta with alpha-7 nicotinic acetylcholine receptors.
    Type: Grant
    Filed: May 27, 1999
    Date of Patent: August 27, 2002
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Allen B. Reitz, David A. Demeter, Daniel H. S. Lee, Hoau-Yan Wang, Robert H. Chen, Tina Morgan Ross, Malcolm K. Scott, Carlos R. Plata-Salaman
  • Novel cyclopentene derivatives useful as antagonists of the motilin receptor
    Publication number: 20020111484
    Abstract: The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.
    Type: Application
    Filed: April 9, 2002
    Publication date: August 15, 2002
    Inventors: Robert H. Chen, Min A. Xiang
  • Novel cyclobutene derivatives useful as antagonists of the motilin receptor
    Publication number: 20020103238
    Abstract: The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.
    Type: Application
    Filed: March 12, 2002
    Publication date: August 1, 2002
    Inventors: Robert H. Chen, Min A. Xiang
  • Cyclohexene derivatives useful as antagonists of the motilin receptor
    Patent number: 6423714
    Abstract: The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.
    Type: Grant
    Filed: March 9, 2001
    Date of Patent: July 23, 2002
    Assignee: Ortho McNeil-Pharmaceutical, Inc..
    Inventors: Robert H. Chen, Min A. Xiang
  • Cyclopentene compounds useful as antagonists of the motilin receptor
    Patent number: 6392040
    Abstract: The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.
    Type: Grant
    Filed: March 9, 2001
    Date of Patent: May 21, 2002
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Robert H. Chen, Min A. Xiang
  • Cyclobutene derivatives useful as antagonists of the motilin receptor
    Patent number: 6384031
    Abstract: The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.
    Type: Grant
    Filed: March 9, 2001
    Date of Patent: May 7, 2002
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Robert H. Chen, Min A. Xiang
  • METHOD OF TREATING NEURODEGENERATIVE DISORDERS VIA INHIBITION OF AMYLOID BETA PEPTIDE BINDING
    Publication number: 20020013374
    Abstract: The invention is directed to a method of treating a neurodegenerative disorder in a subject in need thereof which comprises administering to the subject an amount of a compound effective to inhibit the interaction of amyloid-beta with alpha-7 nicotinic acetylcholine receptors.
    Type: Application
    Filed: May 27, 1999
    Publication date: January 31, 2002
    Inventors: ALLEN B. REITZ, DAVID A. DEMETER, DANIEL H.S. LEE, HOAU-YAN WANG, ROBERT H. CHEN, TINA MORGAN ROSS, MALCOLM K. SCOTT, CARLOS R. PLATA-SALAMAN
  • Novel cyclohexene derivatives useful as antagonists of the motilin receptor
    Publication number: 20020002192
    Abstract: The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.
    Type: Application
    Filed: March 9, 2001
    Publication date: January 3, 2002
    Inventors: Robert H. Chen, Min A Xiang
  • Novel cyclobutene derivatives useful as antagonists of the motilin receptor
    Publication number: 20010056106
    Abstract: The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.
    Type: Application
    Filed: March 9, 2001
    Publication date: December 27, 2001
    Inventors: Robert H. Chen, Min A. Xiang
  • Novel cyclopentene derivatives useful as antagonists of the motilin receptor
    Publication number: 20010041701
    Abstract: The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.
    Type: Application
    Filed: March 9, 2001
    Publication date: November 15, 2001
    Inventors: Robert H. Chen, MIn A. Xiang
  • Cyclopentene derivatives useful as antagonists of the motilin receptor
    Patent number: 5972939
    Abstract: The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor disorders. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.
    Type: Grant
    Filed: October 26, 1998
    Date of Patent: October 26, 1999
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Robert H. Chen, Min Xiang, John B. Moore, Jr., Mary Pat Beavers
  • 2-disubstituted cyclohexenyl and cyclohexyl antimicrobial agents
    Patent number: 5753715
    Abstract: The invention relates to cyclohexenyl antibacterial compounds of the formula I: ##STR1## and pharmaceutical compositions containing the compounds, methods for their production and use.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: May 19, 1998
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Robert H. Chen, Maud Urbanski, Min Xiang, John Francis Barrett