Patents by Inventor Robert H. Cichewicz

Robert H. Cichewicz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200115415
    Abstract: Novel compositions and methods for the treatment and prevention of malaria are disclosed herein.
    Type: Application
    Filed: October 16, 2019
    Publication date: April 16, 2020
    Inventors: Debopam Chakrabarti, Robert H. CICHEWICZ, Shengxin CAI, Jin Woo LEE, Jennifer E. COLLINS
  • Publication number: 20200101038
    Abstract: Certain embodiments are directed to methods for treating Ewing family tumors (EFT) comprising administering an effective amount of altertoxin II to a subject having EFT.
    Type: Application
    Filed: December 20, 2017
    Publication date: April 2, 2020
    Applicants: The Board of Regents of the University of Texas System, The Board of Regents of the University of Oklahoma System
    Inventors: Susan L MOOBERRY, Andrew J ROBLES, April L RISINGER, Robert H CICHEWICZ, Salkat HALDAR, Peter HOUGHTON
  • Publication number: 20200071351
    Abstract: This present disclosure relates to the fields of medicine and pharmaceuticals. In particular, the invention relates to the identification of epoxytaccalonolide microtubule stabilizers for use in inhibiting cell proliferation and disrupting normal cellular microtubule processes leading to cell death. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: December 15, 2017
    Publication date: March 5, 2020
    Inventors: Susan L. Mooberry, April L. Risinger, Robert H. Cichewicz, Lin Du, Jing Li, Jiangnan Peng, Antonius Ola, Samantha S.M. Yee
  • Patent number: 7132403
    Abstract: Anthraquinones are described which are antihelminthic and in particular, are useful in compositions for inhibiting Schistosoma sp. in vitro or in vivo. The preferred anthraquinones have the formula: wherein R1, R2, R3, and R4 are each hydrogen, hydroxy, halogen, alkyl, substituted alkyl, alkene, substituted alkene, alkyne, aryl, substituted aryl, cyclic, substituted cyclic, acid group, carbohydrate, or combination thereof, R is a group containing 1 to 12 carbons such as methyl, alkyl, substituted alkyl, aldehyde, hydroxy, hydroxymethyl, acid group, carbohydrate, or combination thereof, and the halogen is I, F, Br, or Cl.
    Type: Grant
    Filed: January 20, 2004
    Date of Patent: November 7, 2006
    Assignees: Board of Trustees of Michigan State University, Regents of the University of California
    Inventors: Robert H. Cichewicz, Muraleedharan G. Nair, James H. McKerrow
  • Patent number: 6903076
    Abstract: Anthraquinones are described which are antihelminthic and in particular, are useful in compositions for inhibiting Schistosoma sp. in vitro or in vivo. The preferred anthraquinones have the formula: wherein R1, R2, R3, and R4 are each hydrogen, hydroxy, halogen, alkyl, substituted alkyl, alkene, substituted alkene, alkyne, aryl, substituted aryl, cyclic, substituted cyclic, acid group, carbohydrate, or combination thereof, R is a group containing 1 to 12 carbons such as methyl, alkyl, substituted alkyl, aldehyde, hydroxy, hydroxymethyl, acid group, carbohydrate, or combination thereof, and the halogen is I, F, Br, or Cl.
    Type: Grant
    Filed: November 26, 2003
    Date of Patent: June 7, 2005
    Assignees: Board of Trustees of Michigan State University, The Regents of the University of California
    Inventors: Robert H. Cichewicz, Muraleedharan G. Nair, James H. McKerrow
  • Patent number: 6875746
    Abstract: Anthraquinones are described which have anticancer or antitumor activity and which are useful for inhibiting cancer cells and cells comprising tumors in vitro or in vivo. Preferably, the anthraquinones have the chemical formula: wherein R1 is selected from the group consisting of hydrogen, alkyl, and substituted alkyl; R2 is a group containing 1-12 carbons selected from the group consisting of alkyl, substituted alkyl, aldehyde, hydroxy, hydroxymethyl, acid group, carbohydrate and combinations thereof; and R3 is a group containing 1 to 12 carbons selected from the group consisting of methyl, alkyl, substituted alkyl, aldehyde, hydroxy, hydroxymethyl, acid group, carbohydrate, and combinations thereof.
    Type: Grant
    Filed: January 31, 2003
    Date of Patent: April 5, 2005
    Assignee: Board of Trustees of Michigan State University
    Inventors: Muraleedharan G. Nair, Robert H. Cichewicz, Navindra P. Seeram, Yanjun Zhang
  • Patent number: 6838443
    Abstract: Anthraquinones are described which are antihelminthic and in particular, are useful in compositions for inhibiting Schistosoma sp. in vitro or in vivo. The preferred anthraquinones have the formula: wherein R1, R2, R3, and R4 are each hydrogen, hydroxy, halogen, alkyl, substituted alkyl, alkene, substituted alkene, alkyne, aryl, substituted aryl, cyclic, substituted cyclic, acid group, carbohydrate, or combination thereof, R is a group containing 1 to 12 carbons such as methyl, alkyl, substituted alkyl, aldehyde, hydroxy, hydroxymethyl, acid group, carbohydrate, or combination thereof, and the halogen is I, F, Br, or Cl.
    Type: Grant
    Filed: November 26, 2003
    Date of Patent: January 4, 2005
    Assignees: Board of Trustees of Michigan State University, The Regents of the University of California, The United States of America as represented by the Department of Veterans Affairs
    Inventors: Robert H. Cichewicz, Muraleedharan G. Nair, James H. McKerrow
  • Patent number: 6800615
    Abstract: Anthraquinones are described which are antihelminthic and in particular, are useful in compositions for inhibiting Schistosoma sp. in vitro or in vivo. The preferred anthraquinones have the formula: wherein R1, R2, R3, and R4 are each hydrogen, hydroxy, halogen, alkyl, substituted alkyl, alkene, substituted alkene, alkyne, aryl, substituted aryl, cyclic, substituted cyclic, acid group, carbohydrate, or combination thereof, R is a group containing 1 to 12 carbons such as methyl, alkyl, substituted alkyl, aldehyde, hydroxy, hydroxymethyl, acid group, carbohydrate, or combination thereof, and the halogen is I, F, Br, or Cl.
    Type: Grant
    Filed: December 12, 2002
    Date of Patent: October 5, 2004
    Assignees: Board of Trustees of Michigan State University, The Regent of the University of California, The United States of America as represented by the Department of Veterans Affairs
    Inventors: Robert H. Cichewicz, Muraleedharan G. Nair, James H. McKerrow
  • Publication number: 20040152645
    Abstract: Anthraquinones are described which are antihelminthic and in particular, are useful in compositions for inhibiting Schistosoma sp. in vitro or in vivo.
    Type: Application
    Filed: January 20, 2004
    Publication date: August 5, 2004
    Applicants: Board of Trustees of Michigan State University, The Regents of the University of California
    Inventors: Robert H. Cichewicz, Muraleedharan G. Nair, James H. McKerrow
  • Publication number: 20040116361
    Abstract: Anthraquinones are described which are antihelminthic and in particular, are useful in compositions for inhibiting Schistosoma sp. in vitro or in vivo.
    Type: Application
    Filed: November 26, 2003
    Publication date: June 17, 2004
    Applicants: Board of Trustees of Michigan State University, The Regents of the University of California
    Inventors: Robert H. Cichewicz, Muraleedharan G. Nair, James H. McKerrow
  • Publication number: 20040106686
    Abstract: Anthraquinones are described which are antihelminthic and in particular, are useful in compositions for inhibiting Schistosoma sp. in vitro or in vivo.
    Type: Application
    Filed: November 26, 2003
    Publication date: June 3, 2004
    Applicants: Board of Trustees of Michigan State University, The Regents of the University of California
    Inventors: Robert H. Cichewicz, Muraleedharan G. Nair, James H. McKerrow
  • Publication number: 20030229032
    Abstract: Anthraquinones are described which are antihelminthic and in particular, are useful in compositions for inhibiting Schistosoma sp. in vitro or in vivo.
    Type: Application
    Filed: December 12, 2002
    Publication date: December 11, 2003
    Applicants: Board of Trustees of MICHIGAN STATE UNIVERSITY, The Regents of the University of California
    Inventors: Robert H. Cichewicz, Muraleedharan G. Nair, James H. McKerrow