Patents by Inventor Robert H. Lipsky

Robert H. Lipsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR DETECTING ENHANCED NMDA RECEPTOR FUNCTION AND USES THEREOF
    Publication number: 20180291437
    Abstract: A method of determining the risk of cognitive decline in an aging subject is provided. The method includes analyzing an MRNA transcript including a GRIN2B nucleic acid sequence for the presence of the A allele in a biological sample obtained from the subject. The method also includes identifying the subject as having a decreased risk of cognitive decline when the A allele is present.
    Type: Application
    Filed: June 21, 2018
    Publication date: October 11, 2018
    Inventors: Robert H. Lipsky, Mingkuan Lin, Yang Jiang
  • Methods for detecting enhanced NMDA receptor function and uses thereof
    Patent number: 10011863
    Abstract: A method of determining the risk of cognitive decline in an aging subject is provided. The method includes analyzing an MRNA transcript including a GRIN2B nucleic acid sequence for the presence of the A allele in a biological sample obtained from the subject. The method also includes identifying the subject as having a decreased risk of cognitive decline when the A allele is present.
    Type: Grant
    Filed: May 8, 2017
    Date of Patent: July 3, 2018
    Assignee: INOVA HEALTH SYSTEM
    Inventors: Robert H. Lipsky, Mingkuan Lin, Yang Jiang
  • METHODS FOR DETECTING ENHANCED NMDA RECEPTOR FUNCTION AND USES THEREOF
    Publication number: 20170349943
    Abstract: A method of determining the risk of cognitive decline in an aging subject is provided. The method includes analyzing an MRNA transcript including a GRIN2B nucleic acid sequence for the presence of the A allele in a biological sample obtained from the subject. The method also includes identifying the subject as having a decreased risk of cognitive decline when the A allele is present.
    Type: Application
    Filed: May 8, 2017
    Publication date: December 7, 2017
    Inventors: Robert H. Lipsky, Mingkuan Lin, Yang Jiang
  • Methods for detecting nucleic acid sequence variation
    Patent number: 7273699
    Abstract: Sequence variations, such as polymorphisms, are detected by detecting differences between or among melting profiles of plural nucleic acids. Melting profiles are produced by observing the nucleic acids during a temperature change over a period of time. If the nucleic acids are diluted into solutions for analysis, the nucleic acid concentrations between or among the solutions can be substantially the same. The melting profiles and sequence variation can be used to identify changes in a wild-type nucleic acid sequence, such as a single-nucleotide polymorphism (SNP), a small insertion or deletion, or a small inversion.
    Type: Grant
    Filed: July 25, 2002
    Date of Patent: September 25, 2007
    Assignee: The United States of America as Represented by the Secretary of the Department of Health and Human Services
    Inventors: Robert H. Lipsky, Chiara Mazzanti, David Goldman
  • Methods for detecting nucleic acid sequence variation
    Publication number: 20030157507
    Abstract: Sequence variations, such as polymorphisms, are detected by detecting differences between or among melting profiles of plural nucleic acids. Melting profiles are produced by observing the nucleic acids during a temperature change over a period of time. If the nucleic acids are diluted into solutions for analysis, the nucleic acid concentrations between or among the solutions can be substantially the same. The melting profiles and sequence variation can be used to identify changes in a wild-type nucleic acid sequence, such as a single-nucleotide polymorphism (SNP), a small insertion or deletion, or a small inversion.
    Type: Application
    Filed: July 25, 2002
    Publication date: August 21, 2003
    Applicant: The Government of the U.S.A., as represented by the Secretary, Dept. of Health and Human Services
    Inventors: Robert H. Lipsky, Chiara M. Mazzanti, David Goldman