Patents by Inventor Robert H. Mazur
Robert H. Mazur has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5137904Abstract: A series of ethers and thioethers of 5-methanol thiohydantoins, unsubstituted at the number one position heterocyclic nitrogen atom of the thiohydantoin ring, useful in reversing the effects of collagen and ADP-induced platelet aggregation.Type: GrantFiled: May 30, 1989Date of Patent: August 11, 1992Assignee: G. D. Searle & Co.Inventors: John S. Baran, Tom Lindberg, Robert H. Mazur, Alan E. Moorman, Doug Steinman
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Patent number: 4727189Abstract: The invention relates to novel substituted tyrosyl alanine dipeptide amides of the formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein R.sub.1 represents straight or branched lower alkyl having 1 to 4 carbons;R.sub.2 represents hydrogen, hydroxy, --OCO.sub.2 R.sub.1 substituent or lower alkyl having 1 to 4 carbons;R.sub.3 represents a hydrogen or lower alkyl having 1 to 6 carbons;R.sub.4 and R.sub.5 may be the same or different and represent hydrogen or lower alkyl having 1 to 6 carbons;n is 1 to 6;X represents a hydrogen, hydroxy or OCO.sub.2 R.sub.1 substituent;A represents a cyclohexyl, phenyl or phenyl substituted with one or more lower alkyls containing 1 to 6 carbons, one or more amino, hydroxy, halogen, nitro or lower alkoxy substituent having 1 to 6 carbons;V represents the asymmetric carbon that may be racemic or have the D or L configuration;W represents the asymmetric carbon when R.sub.4 and R.sub.Type: GrantFiled: April 14, 1986Date of Patent: February 23, 1988Assignee: G. D. Searle & Co.Inventors: Donald W. Hansen, Jr., Robert H. Mazur, Daniel R. Pilipauskas
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Patent number: 4722922Abstract: The invention relates to tetrapeptides of the formula I: ##STR1## which are useful as renin inhibition/antihypertensive agents.Type: GrantFiled: January 22, 1985Date of Patent: February 2, 1988Assignee: G. D. Searle & Co.Inventors: Donald W. Hansen, Jr., David A. Jones, Jr., Robert H. Mazur, James M. Schlatter
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Patent number: 4603121Abstract: The invention relates to novel enkephalin analogs of the formula: ##STR1## which are useful as analgesic agents.Type: GrantFiled: September 14, 1984Date of Patent: July 29, 1986Assignee: G. D. Searle & Co.Inventors: Donald W. Hansen, Jr., David A. Jones, Jr., Robert H. Mazur, James M. Schlatter
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Patent number: 4599325Abstract: The invention relates to novel substituted tyrosyl alanine dipeptide amides of the formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein R.sub.1 represents straight or branched lower alkyl having 1 to 4 carbons;R.sub.2 represents hydrogen, hydroxy, --OCO.sub.2 R.sub.1 substituent or lower alkyl having 1 to 4 carbons;R.sub.3 represents a hydrogen or lower alkyl having 1 to 6 carbons;R.sub.4 and R.sub.5 may be the same or different and represent hydrogen or lower alkyl having 1 to 6 carbons;n is 1 to 6;X represents a hydrogen, hydroxy or OCO.sub.2 R.sub.1 substituent;A represents a cyclohexyl, phenyl or phenyl substituted with one or more lower alkyls containing 1 to 6 carbons, one or more amino, hydroxy, halogen, nitro or lower alkoxy substituent having 1 to 6 carbons;V represents the asymmetric carbon that may be racemic or have the D or L configuration;W represents the asymmetric carbon when R.sub.4 and R.sub.Type: GrantFiled: January 22, 1985Date of Patent: July 8, 1986Assignee: G. D. Searle & Co.Inventors: Donald W. Hansen, Jr., Robert H. Mazur, Daniel R. Pilipauskas
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Patent number: 4495178Abstract: The invention relates to novel enkephalin analogs of the formula: ##STR1## which are useful as analgesic agents.Type: GrantFiled: October 6, 1983Date of Patent: January 22, 1985Assignee: G. D. Searle & Co.Inventors: Donald W. Hansen, Jr., David A. Jones, Jr., Robert H. Mazur, James M. Schlatter
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Patent number: 4407746Abstract: The invention discloses cyclohexyl and phenyl substituted enkephalin derivatives of the formula: ##STR1## Where R.sub.1, R.sub.2, R.sub.4, and R.sub.8 is hydrogen or alkyl of R.sub.3 is alkylthioalkyl or alkylsulfinylalkyl, X is: ##STR2## R.sub.5 is cyclohexylmethyl, phenylmethyl, optionally substituted by --NO.sub.2, R.sub.6 is cyclohexyl or phenyl optionally substituted by R.sub.7 and R.sub.7 is hydrogen, an alkyl ester of carboxylic acid or hydroxyalkyl and the pharmaceutically acceptable salts, which are useful as analgesic agents.Type: GrantFiled: December 14, 1981Date of Patent: October 4, 1983Assignee: G. D. Searle & Co.Inventors: Robert H. Mazur, David A. Tyner, Eleanor A. Hallinan
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Patent number: 4273704Abstract: N-Adamantane-substituted tetrapeptide amides and the pharmacologically acceptable salts thereof are disclosed herein. These compounds are analogs of enkephalin wherein the methionine or leucine of position 5 has been substituted by an adamantyl amide and the glycine of position 2 has been substituted by various amino acid residues. Optionally the tyrosine of position 1 and the phenylalanine of position 4 may be substituted by various amino acid residues. These compounds exhibit agonist activity at opiate receptor sites and are useful as analgesics.Type: GrantFiled: December 3, 1979Date of Patent: June 16, 1981Assignee: G. D. Searle & Co.Inventor: Robert H. Mazur
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Patent number: 4204991Abstract: The sarcosine.sup.1 dehydroalanine.sup.8 angiotensin II derivatives of the present invention are potent angiotensin blockers.Type: GrantFiled: May 14, 1979Date of Patent: May 27, 1980Assignee: G. D. Searle & Co.Inventors: E. Ann Hallinan, Robert H. Mazur
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Patent number: 4028319Abstract: Analogs of enkephalin having agonist activity at opiate receptors are disclosed herein. These analogs are useful as analgesics, non-addicting narcotic antagonists and anti-diarrheal agents.Type: GrantFiled: May 7, 1976Date of Patent: June 7, 1977Assignee: G. D. Searle & Co.Inventors: David A. Jones, Jr., James M. Schlatter, Richard A. Mikulec, Judith A. Reuter, Robert H. Mazur
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Patent number: 4025551Abstract: 3-Amino-N-substituted succinamic acids, prepared by coupling of a protected L-aspartic acid derivative with the appropriate amine followed by cleavage of the protecting groups, are potent sweetening agents and also exhibit pharmacological, e.g. anti-inflammatory, properties.Type: GrantFiled: December 22, 1975Date of Patent: May 24, 1977Assignee: G. D. Searle & Co.Inventors: Arthur H. Goldkamp, Robert H. Mazur, James M. Schlatter
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Patent number: 4012367Abstract: This invention encompasses novel tetrapeptide amides and their intermediates containing an L-aspartic acid residue. These peptides are inhibitors of gastric acid secretion and therefore useful in the treatment of ulcers.Type: GrantFiled: February 5, 1976Date of Patent: March 15, 1977Assignee: G. D. Searle & Co.Inventor: Robert H. Mazur
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Patent number: 4011260Abstract: The above-captioned compounds, prepared by coupling of a protected L-aspartic acid derivative with the appropriate amine followed by cleavage of the protecting groups, are potent sweetening agents and exhibit also pharmacological, e.g. anti-inflammatory, properties.Type: GrantFiled: February 14, 1974Date of Patent: March 8, 1977Assignee: G. D. Searle & Co.Inventors: Arthur H. Goldkamp, Robert H. Mazur, James M. Schlatter
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Patent number: 3975365Abstract: Octapeptide derivatives characterized by an oxygen or sulfur-containing moiety in the C-terminal position are potent inhibitors of the pharmacological effects of Angiotensin and possess the additional advantage of a favorable antagonist/agonist ratio.Type: GrantFiled: January 27, 1975Date of Patent: August 17, 1976Assignee: G. D. Searle & Co.Inventor: Robert H. Mazur
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Patent number: RE29324Abstract: Peptides containing the residues of methionine and aspartic acid are prepared by standard coupling techniques and display valuable pharmacological, e.g. gastrin-inhibitory, properties.Type: GrantFiled: February 5, 1976Date of Patent: July 26, 1977Assignee: G. D. Searle & Co.Inventors: David A. Jones, Robert H. Mazur