Patents by Inventor Robert H. Purcell

Robert H. Purcell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HCV/BVDV chimeric genomes and uses thereof
    Patent number: 7009044
    Abstract: The present invention relates to molecular approaches to the production of nucleic acid sequences which comprise the genomes of chimeric hepatitis C virus-bovine viral diarrhea viruses (HCV/BVDV). The invention also relates to the use of these chimeric nucleic acid sequences to produce chimeric virions in cells and the use of these chimeric virions in HCV antibody neutralization assays, and for the development of vaccines and therapeutics for HCV.
    Type: Grant
    Filed: February 6, 2000
    Date of Patent: March 7, 2006
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Jae-Hwan Nam, Jens Bukh, Suzanne U. Emerson, Robert H. Purcell
  • Major neutralization site of hepatitis E virus and use of this neutralization site in methods of vaccination and in methods of screening for neutralizing antibodies to hepatitis E virus
    Patent number: 6930176
    Abstract: The invention describes the identification of major neutralization site of hepatitis E virus (HEV) and the use of this neutralization site in methods of vaccination and in methods of screening for neutralizing antibodies to HEV. The invention also describes the isolation and characterization of neutralizing chimpanzee monoclonal antibodies reactive to the neutralization site and the use of these antibodies in the diagnosis, treatment and prevention of HEV.
    Type: Grant
    Filed: November 30, 2000
    Date of Patent: August 16, 2005
    Assignee: The United States of America as represented by the Secretary of the Department of Health & Human Services
    Inventors: Darren Schofield, Suzanne U. Emerson, Robert H. Purcell
  • Monoclonal antibodies specific for the E2 glycoprotein of hepatitic C virus and their use in the diagnosis, treatment, and prevention of hepatitis C
    Patent number: 6924362
    Abstract: The present invention describes the identification and characterization of five human HC E1-specific monoclonal antibodies isolated from a phage display library and their use in the diagnosis, treatment, and prevention of HCV in mammals, preferably humans.
    Type: Grant
    Filed: November 30, 2001
    Date of Patent: August 2, 2005
    Assignee: The United States of America as represented by the Department of Health & Human Services
    Inventors: Darren Schofield, Suzanne U. Emerson, Robert H. Purcell, Harvey J. Alter
  • Anti-hepatitis a virus antibodies
    Publication number: 20040260067
    Abstract: Chimpanzee monoclonal antibodies and antigen binding fragments including a &ggr;1-chain CDR3 region that bind hepatitis A virus (HAV) antigen are disclosed herein. The antibodies neutralize HAV. Also disclosed are methods for using these antibodies and antigen binding fragments in the detection of hepatitis A virus, the inhibition of infection of a subject with hepatitis A virus, and in screening for agents that affect HAV.
    Type: Application
    Filed: May 4, 2004
    Publication date: December 23, 2004
    Inventors: Darren J. Schofield, Suzanne U Emerson, Robert H Purcell
  • Recombinant orf2 proteins of the swine hepatitis e virus and their use as a vaccine and as a diagnostic reagent for medical and veterinary applications
    Publication number: 20040234542
    Abstract: The invention relates to open reading frame 2 (ORF-2) proteins of a swine hepatitis E virus and the use of these proteins as an antigen in diagnostic immunoassays and/or as immunogen or vaccine to protect against infection by hepatitis E.
    Type: Application
    Filed: June 7, 2004
    Publication date: November 25, 2004
    Inventors: Xiang-Jin Meng, Robert H Purcell, Suzanne U Emerson
  • Recombinant proteins of a pakistani strain of hepatitis E and their use in diagnostic methods and vaccines
    Patent number: 6787145
    Abstract: A strain of hepatitis E virus from Pakistan (SAR-55) implicated in an epidemic of enterically transmitted non-A, non-B hepatitis, now called hepatitis E, is disclosed. The invention relates to the expression of the whole structural region of SAR-55, designated open reading frame 2 (ORF-2), in a eukaryotic expression system. The expressed protein is capable of forming HEV virus-like particles which can serve as an antigen in diagnostic immunoassays and as an immunogen or vaccine to protect against infection by hepatitis E.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: September 7, 2004
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Sergei A. Tsarev, Suzanne U. Emerson, Robert H. Purcell
  • Monoclonal antibodies specific for the e2 glycoprotein of hepatitic c virus and their use in the diagnosis, treatment , and prevention of hepatitis c
    Publication number: 20040115619
    Abstract: The present invention describes the identification and characterization of five human HC E2-specific monoclonal antibodies isolated form a phage display library and their use in the diagnosis, treatment, and prevention of HCV in mammals, preferably humans.
    Type: Application
    Filed: December 15, 2003
    Publication date: June 17, 2004
    Inventors: Darren Schofield, Suzanne U Emerson, Robert H Purcell, Harvey J Alter
  • Recombinant proteins of a pakistani strain of hepatitis E and their use in diagnostic methods and vaccines
    Patent number: 6706873
    Abstract: A strain of hepatitis E virus from Pakistan (SAR-55) implicated in an epidemic of enterically transmitted non-A, non-B hepatitis, now called hepatitis E, is disclosed. The invention relates to the expression of the whole structural region of SAR-55, designated open reading frame 2 (ORF-2), in a eukaryotic expression system. The expressed protein is capable of forming HEV virus-like particles which can serve as an antigen in diagnostic immunoassays and as an immunogen or vaccine to protect against infection by hepatitis E.
    Type: Grant
    Filed: October 3, 1994
    Date of Patent: March 16, 2004
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Sergei A. Tsarev, Suzanne U. Emerson, Robert H. Purcell
  • Recombinant proteins of a Pakistani strain of hepatitis E and their use in diagnostic methods and vaccines
    Patent number: 6696242
    Abstract: A strain of hepatitis E virus from Pakistan (SAR-55) implicated in an epidemic of enterically transmitted non-A, non-B hepatitis, now called hepatitis E, is disclosed. The invention relates to the expression of the whole structural region of SAR-55, designated open reading frame 2 (ORF-2), in a eukaryotic expression system. The expressed protein is capable of forming HEV virus-like particles which can serve as an antigen in diagnostic immunoassays and as an immunogen or vaccine to protect against infection by hepatitis E.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: February 24, 2004
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Sergei A. Tsarev, Suzanne U. Emerson, Robert H. Purcell
  • Hepatitus A virus vaccines
    Patent number: 6680060
    Abstract: A live hepatitis A virus adapted to growth in MRC-5 cells, which HAV is preferably characterized by suitable attenuation for effective vaccine administration to humans and animals without inactivation, methods for adapting HAV to growth in MRC-5, vaccine compositions and method of vaccinating humans against HAV infection.
    Type: Grant
    Filed: April 29, 2002
    Date of Patent: January 20, 2004
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Ann W. Funkhouser, Suzanne U. Emerson, Robert H. Purcell, Eric D'Hondt
  • Major neutralization site of hepatitis e virus and use of this neutralization site in methods of vaccination and in methods of screening for neutralizing antibodies to hepatitis e virus
    Publication number: 20030211463
    Abstract: The invention describes the identification of major neutralization site of hepatitis E virus (HEV) and the use of this neutralization site in methods of vaccination and in methods of screening for neutralizing antibodies to HEV. The invention also describes the isolation and characterization of neutralizing chimpanzee monoclonal antibodies reactive to the neutralization site and the use of these antibodies in the diagnosis, treatment and prevention of HEV.
    Type: Application
    Filed: January 27, 2003
    Publication date: November 13, 2003
    Inventors: Darren Schofield, Suzanne U. Emerson, Robert H. Purcell
  • Nucleotide and deduced amino acid sequences of the envelope 1 gene of 51 isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines
    Patent number: 6572864
    Abstract: The nucleotide and deduced amino acid sequences of 51 cDNAs are disclosed where each cDNA encodes the envelope 1 gene of an isolate of hepatitis C virus (HCV). The invention relates to the oligonucleotides, peptides and recombinant envelope 1 proteins derived from these sequences and their use in diagnostic methods and vaccines.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 3, 2003
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Jens Bukh, Roger H. Miller, Robert H. Purcell
  • Hepatitus A virus vaccines
    Publication number: 20020176869
    Abstract: A live hepatitis A virus adapted to growth in MRC-5 cells, which HAV is preferably characterized by suitable attenuation for effective vaccine administration to humans and animals without inactivation, methods for adapting HAV to growth in MRC-5, vaccine compositions and method of vaccinating humans against HAV infection.
    Type: Application
    Filed: April 29, 2002
    Publication date: November 28, 2002
    Inventors: Ann W. Funkhouser, Suzanne U. Emerson, Robert H. Purcell, Eric D'Hondt
  • Recombinant proteins of a Pakistani strain of hepatitis E and their use in diagnostic methods and vaccines
    Patent number: 6458562
    Abstract: The invention relates to the expression of open reading frame 2 (ORF-2) proteins of a strain of hepatitis E virus from Pakistan (SAR-55) in a eukaryotic expression system. The expressed proteins can serve as an antigen in diagnostic immunoassays and/or as an immunogen or vaccine to protect against infection by hepatitis E.
    Type: Grant
    Filed: February 22, 2000
    Date of Patent: October 1, 2002
    Assignees: The United States of America as represented by the Secretary of Health and Human Services, Novavax, Inc.
    Inventors: Suzanne U. Emerson, Robert H. Purcell, Sergei A. Tsarev, Robin A. Robinson
  • Swine hepatitis E virus and uses thereof
    Patent number: 6432408
    Abstract: The present invention discloses the isolation and chaterization of a novel swine hepatitis E virus and the use of the virus, the proteins and its nucleic acid sequence as diagnostic reagents and vaccines.
    Type: Grant
    Filed: June 12, 2000
    Date of Patent: August 13, 2002
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Xiang-Jin Meng, Suzanne U. Emerson, Robert H. Purcell
  • Hepatitis A virus vaccines
    Patent number: 6423318
    Abstract: A live hepatitis A virus adapted to growth in MRC-5 cells, which HAV is preferably characterized by suitable attenuation for effective vaccine administration to humans and animals without inactivation, methods for adapting HAV to growth in MRC-5, vaccine compositions and method of vaccinating humans against HAV infection.
    Type: Grant
    Filed: August 31, 2000
    Date of Patent: July 23, 2002
    Assignees: The United States of America as represented by the Department of Health and Human Services, SmithKline Beecham Biologicals
    Inventors: Ann W. Funkhouser, Suzanne U. Emerson, Robert H. Purcell, Eric D'Hondt
  • Recombinant proteins of a Pakistani strain of hepatitis E and their use in diagnostic methods and vaccines
    Patent number: 6287759
    Abstract: A strain of hepatitis E virus from Pakistan (SAR-55) implicated in an epidemic of enterically transmitted non-A, non-B hepatitis, now called hepatitis E, is disclosed. The invention relates to the expression of the whole structural region of SAR-55, designated open reading frame 2 (ORF-2), in a eukaryotic expression system. The expressed protein is capable of forming HEV virus-like particles which can serve as an antigen in diagnostic immunoassays and as an immunogen or vaccine to protect against infection by hepatitis E.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: September 11, 2001
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Sergei A. Tsarev, Suzanne U. Emerson, Robert H. Purcell
  • Simian-human HAV having a chimeric 2C protein
    Patent number: 6280734
    Abstract: The present invention discloses simian-human hepatitis A virus chimeric genomes which encode a hepatitis A virus having a chimeric 2C protein. The invention further discloses the use of these viruses or the nucleic acid sequence encoding them as vaccines.
    Type: Grant
    Filed: March 24, 1999
    Date of Patent: August 28, 2001
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Gopa Raychaudhuri, Suzanne U. Emerson, Robert H. Purcell
  • Recombinant proteins of a Pakistani strain of hepatitis E and their use in diagnostic methods and vaccines
    Patent number: 6207416
    Abstract: A strain of hepatitis E virus from Pakistan (SAR-55) implicated in an epidemic of enterically transmitted non-A, non-B hepatitis, now called hepatitis E, is disclosed. The invention relates to the expression of the whole structural region of SAR-55, designated open reading frame 2 (ORF-2), in a eukaryotic expression system. The expressed protein is capable of forming HEV virus-like particles which can serve as an antigen in diagnostic immunoassays and as an immunogen or vaccine to protect against infection by hepatitis E.
    Type: Grant
    Filed: May 28, 1997
    Date of Patent: March 27, 2001
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Sergei A. Tsarev, Suzanne U. Emerson, Robert H. Purcell
  • Vaccine against hepatitis A virus
    Patent number: RE37381
    Abstract: The present invention provides an attenuated hepatitis A virus useful as a vaccine.
    Type: Grant
    Filed: September 6, 1995
    Date of Patent: September 18, 2001
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Robert H. Purcell, John R. Ticehurst, Jeffrey I. Cohen, Suzanne U. Emerson, Stephen M. Feinstone, Richard J. Daemer, Ian D. Gust