Patents by Inventor Robert H. Shoemaker
Robert H. Shoemaker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10913709Abstract: Disclosed is a salt prepared from the STAT3 inhibitor known as 2-hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino] benzoic acid and 2-amino-2-(hydroxymethyl)-1,3-propanediol. The salt is soluble in water and stable for extended periods of time. Further provided are pharmaceutical compositions comprising the salt and methods of administering the salt to prevent and treat cancer, such as breast cancer.Type: GrantFiled: April 5, 2018Date of Patent: February 9, 2021Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, GLG Pharma, LLC, MRIGlobalInventors: Robert H. Shoemaker, Michael W. Lovell, Jonathan M. White, Shanker Gupta
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Publication number: 20200109109Abstract: Disclosed is a salt prepared from the STAT3 inhibitor known as 2-hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino] benzoic acid and 2-amino-2-(hydroxymethyl)-1,3-propanediol. The salt is soluble in water and stable for extended periods of time. Further provided are pharmaceutical compositions comprising the salt and methods of administering the salt to prevent and treat cancer, such as breast cancer.Type: ApplicationFiled: April 5, 2018Publication date: April 9, 2020Applicants: The United States of America,as represented by the Secretary,Department of Health and Human Services, GLG Pharma, LLC, MRIGlobalInventors: Robert H. Shoemaker, Michael W. Lovell, Jonathan M. White, Shanker Gupta
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Patent number: 9278089Abstract: A method of treating an Hepatitis C Virus infection in a patient, comprising providing a therapeutically effective amount, to a patient in need thereof, of a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: G1 is a group of the formula or where n is 0, 1, 2, 3, or 4 and Het is a 5- or 6-membered heteroaryl group containing 1 to 4 heteroatoms independently chosen from N, O, and S, which Het is optionally substituted.Type: GrantFiled: October 26, 2012Date of Patent: March 8, 2016Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICESInventors: David Waugh, Christopher Self, Guangtao Zhang, Yves Pommier, Robert H. Shoemaker, Michael Currens, John Cardellina, Andrew Jobson, George Lountos, Dominic Scudiero
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Patent number: 8912214Abstract: Described herein are Chk2-inhibitor compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof.Type: GrantFiled: July 27, 2006Date of Patent: December 16, 2014Assignee: The United States of America, as Represented by the Secretary, Department of Health and Human ServicesInventors: Yves Pommier, Robert H. Shoemaker, Dominic Scudiero, Michael Currens, John Cardellina, Andrew Jobson
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Publication number: 20140294767Abstract: A method of treating an Hepatitis C Virus infection in a patient, comprising providing a therapeutically effective amount, to a patient in need thereof, of a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: G1 is a group of the formula or where n is 0, 1, 2, 3, or 4 and Het is a 5- or 6-membered heteroaryl group containing 1 to 4 heteroatoms independently chosen from N, O, and S, which Het is optionally substituted.Type: ApplicationFiled: October 26, 2012Publication date: October 2, 2014Inventors: David Waugh, Christopher Self, Guangtao Zhang, Yves Pommier, Robert H. Shoemaker, Michael Currens, John Cardellina, Andrew Jobson, George Lountos, Dominic Scudiero
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Publication number: 20100069423Abstract: Described herein are Chk2-inhibitor compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof.Type: ApplicationFiled: July 27, 2006Publication date: March 18, 2010Applicant: Government of the US, as represented by the Secretary, Department of Health and Human ServicesInventors: Yves Pommier, Robert H. Shoemaker, Dominic Scudiero, Michael Currens, John Cardellina, Andrew Jobson
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Patent number: 7572828Abstract: The invention provides methods and pharmaceutical compositions for inhibiting viral replication, particularly retroviral replication. The methods comprise administration of stibonic acid or diphenyl compounds that disrupt viral nucleocapsid binding to nucleic acids.Type: GrantFiled: October 8, 2003Date of Patent: August 11, 2009Assignee: The United States of America as represented by the Secretary of the Department of Health and Human ServicesInventors: Robert H. Shoemaker, Michael Currens, Alan Rein, Hang Yuan, legal representative, Robert Fisher, Andrew Stephen, Karen Worthy, Shizuko Sei, Bruce Crise, Louis E. Henderson, Ya-Xiong Feng
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Publication number: 20090192077Abstract: A method for the prevention or treatment of Kaposi's sarcoma or Kaposi's sarcoma-associated herpes virus infection by administering an effective amount of a cyclopropanated carbocyclic 2?-deoxynucleoside to an individual in need thereof is provided.Type: ApplicationFiled: April 11, 2006Publication date: July 30, 2009Inventors: Shizuko Sei, Victor Marquez, Robert H. Shoemaker
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Patent number: 7465237Abstract: A magnetic golf putting training device (1) having an attachment device (10) with two arms (3a and 3b), a clamp (25) for removably attaching the attachment device (10) to a putter (2), magnets (11a and 11b) located on the arms (3a and 3b) and guiding magnets (12a and 12b). The arms (3a and 3b) are located on each end of the putter head (9) during use. The guiding magnets (12a and 12b) are positioned such that they are substantially perpendicular to the putter head (9) and such that the electromagnetic field of each guiding magnets (12a and 12b) is facing towards the like electromagnetic field of each magnet (11a and 11b) located on the arms (3a and 3b) so as to create a repelling force (28).Type: GrantFiled: April 30, 2008Date of Patent: December 16, 2008Inventor: Robert H. Shoemaker
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Patent number: 6987096Abstract: The present invention provides antiviral proteins (collectively referred to as cyanovirins), conjugates thereof, DNA sequences encoding such agents, host cells containing such DNA sequences, antibodies directed to such agents, compositions comprising such agents, and methods of obtaining and using such agents.Type: GrantFiled: November 13, 1997Date of Patent: January 17, 2006Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Michael R. Boyd, Kirk R. Gustafson, Robert H. Shoemaker, James B. McMahon
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Patent number: 6245737Abstract: The present invention provides antiviral proteins, peptides and conjugates, as well as methods of obtaining these agents. The antiviral proteins, peptides and conjugates of the present invention can be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the infectivity, replication and cytopathic effects of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2, in the treatment or prevention of viral infection.Type: GrantFiled: August 19, 1998Date of Patent: June 12, 2001Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Michael R. Boyd, Kirk R. Gustafson, Robert H. Shoemaker, James B. McMahon
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Patent number: 5998587Abstract: The present invention provides antiviral proteins (collectively referred to as cyanovirins), conjugates thereof, DNA sequences ending such agents, host cells containing such DNA sequences, antibodies directed to such agents, compositions comprising such agents, and methods of obtaining and using such agents.Type: GrantFiled: November 13, 1997Date of Patent: December 7, 1999Assignee: The United States of America, represented by the Secretary of the Department of Health and Human ServicesInventors: Michael R. Boyd, Kirk R. Gustafson, Robert H. Shoemaker, James B. McMahon
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Patent number: 5962668Abstract: The present invention provides antiviral proteins (collectively referred to as cyanovirins), conjugates thereof, DNA sequences encoding such agents, host cells containing such DNA sequences, antibodies directed to such agents, compositions comprising such agents, and methods of obtaining and using such agents.Type: GrantFiled: November 13, 1997Date of Patent: October 5, 1999Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Michael R. Boyd, Robert H. Shoemaker
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Patent number: 5843882Abstract: The present invention provides antiviral proteins, peptides and conjugates, as well as methods of obtaining these agents. The antiviral proteins, peptides and conjugates of the present invention can be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the infectivity, replication and cytopathic effects of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2, in the treatment or prevention of viral infection.Type: GrantFiled: April 27, 1995Date of Patent: December 1, 1998Assignee: The United States of America as Represented by the Department of Health and Human ServicesInventors: Michael R. Boyd, Kirk R. Gustafson, Robert H. Shoemaker, James B. McMahon
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Patent number: 5821081Abstract: The present invention provides antiviral proteins (collectively referred to as cyanovirins), conjugates thereof, DNA sequences encoding such agents, host cells containing such DNA sequences, antibodies directed to such agents, compositions comprising such agents, and methods of obtaining and using such agents.Type: GrantFiled: April 26, 1996Date of Patent: October 13, 1998Assignee: The United States of Americaa as represented by the Secretary of the Department of Health and Human ServicesInventors: Michael R. Boyd, Kirk R. Gustafson, Robert H. Shoemaker, James B. McMahon
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Patent number: 4113511Abstract: A method and apparatus is disclosed where aqueous solutions of chemicals are added to fused non-aqueous baths. This is done by spraying the aqueous solution of the chemicals onto the surface of the fused bath in a fine spray, causing the evaporation of the water.Type: GrantFiled: January 17, 1977Date of Patent: September 12, 1978Inventors: Robert H. Shoemaker, William G. Wood
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Patent number: 3951681Abstract: A ferrous metal product to be cleaned is immersed in an oxidizing molten salt bath forming a conditioned scale on the surface of the metal. The conditioned scale is subsequently removed from the metal surface by immersing the metal product in an aqueous caustic bath containing alkali metal hydroxide with alkali gluconate and triethanolamine serving as sequestering agents. The caustic bath may optionally include a brightening catalyst or ethylenediamine-tetracetic acid.Type: GrantFiled: November 1, 1973Date of Patent: April 20, 1976Assignee: Kolene CorporationInventors: Robert H. Shoemaker, William G. Wood