Patents by Inventor Robert H. Shoemaker

Robert H. Shoemaker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10913709
    Abstract: Disclosed is a salt prepared from the STAT3 inhibitor known as 2-hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino] benzoic acid and 2-amino-2-(hydroxymethyl)-1,3-propanediol. The salt is soluble in water and stable for extended periods of time. Further provided are pharmaceutical compositions comprising the salt and methods of administering the salt to prevent and treat cancer, such as breast cancer.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: February 9, 2021
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, GLG Pharma, LLC, MRIGlobal
    Inventors: Robert H. Shoemaker, Michael W. Lovell, Jonathan M. White, Shanker Gupta
  • Publication number: 20200109109
    Abstract: Disclosed is a salt prepared from the STAT3 inhibitor known as 2-hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino] benzoic acid and 2-amino-2-(hydroxymethyl)-1,3-propanediol. The salt is soluble in water and stable for extended periods of time. Further provided are pharmaceutical compositions comprising the salt and methods of administering the salt to prevent and treat cancer, such as breast cancer.
    Type: Application
    Filed: April 5, 2018
    Publication date: April 9, 2020
    Applicants: The United States of America,as represented by the Secretary,Department of Health and Human Services, GLG Pharma, LLC, MRIGlobal
    Inventors: Robert H. Shoemaker, Michael W. Lovell, Jonathan M. White, Shanker Gupta
  • Patent number: 9278089
    Abstract: A method of treating an Hepatitis C Virus infection in a patient, comprising providing a therapeutically effective amount, to a patient in need thereof, of a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: G1 is a group of the formula or where n is 0, 1, 2, 3, or 4 and Het is a 5- or 6-membered heteroaryl group containing 1 to 4 heteroatoms independently chosen from N, O, and S, which Het is optionally substituted.
    Type: Grant
    Filed: October 26, 2012
    Date of Patent: March 8, 2016
    Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: David Waugh, Christopher Self, Guangtao Zhang, Yves Pommier, Robert H. Shoemaker, Michael Currens, John Cardellina, Andrew Jobson, George Lountos, Dominic Scudiero
  • Patent number: 8912214
    Abstract: Described herein are Chk2-inhibitor compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof.
    Type: Grant
    Filed: July 27, 2006
    Date of Patent: December 16, 2014
    Assignee: The United States of America, as Represented by the Secretary, Department of Health and Human Services
    Inventors: Yves Pommier, Robert H. Shoemaker, Dominic Scudiero, Michael Currens, John Cardellina, Andrew Jobson
  • Publication number: 20140294767
    Abstract: A method of treating an Hepatitis C Virus infection in a patient, comprising providing a therapeutically effective amount, to a patient in need thereof, of a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: G1 is a group of the formula or where n is 0, 1, 2, 3, or 4 and Het is a 5- or 6-membered heteroaryl group containing 1 to 4 heteroatoms independently chosen from N, O, and S, which Het is optionally substituted.
    Type: Application
    Filed: October 26, 2012
    Publication date: October 2, 2014
    Inventors: David Waugh, Christopher Self, Guangtao Zhang, Yves Pommier, Robert H. Shoemaker, Michael Currens, John Cardellina, Andrew Jobson, George Lountos, Dominic Scudiero
  • Publication number: 20100069423
    Abstract: Described herein are Chk2-inhibitor compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof.
    Type: Application
    Filed: July 27, 2006
    Publication date: March 18, 2010
    Applicant: Government of the US, as represented by the Secretary, Department of Health and Human Services
    Inventors: Yves Pommier, Robert H. Shoemaker, Dominic Scudiero, Michael Currens, John Cardellina, Andrew Jobson
  • Patent number: 7572828
    Abstract: The invention provides methods and pharmaceutical compositions for inhibiting viral replication, particularly retroviral replication. The methods comprise administration of stibonic acid or diphenyl compounds that disrupt viral nucleocapsid binding to nucleic acids.
    Type: Grant
    Filed: October 8, 2003
    Date of Patent: August 11, 2009
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Robert H. Shoemaker, Michael Currens, Alan Rein, Hang Yuan, legal representative, Robert Fisher, Andrew Stephen, Karen Worthy, Shizuko Sei, Bruce Crise, Louis E. Henderson, Ya-Xiong Feng
  • Publication number: 20090192077
    Abstract: A method for the prevention or treatment of Kaposi's sarcoma or Kaposi's sarcoma-associated herpes virus infection by administering an effective amount of a cyclopropanated carbocyclic 2?-deoxynucleoside to an individual in need thereof is provided.
    Type: Application
    Filed: April 11, 2006
    Publication date: July 30, 2009
    Inventors: Shizuko Sei, Victor Marquez, Robert H. Shoemaker
  • Patent number: 7465237
    Abstract: A magnetic golf putting training device (1) having an attachment device (10) with two arms (3a and 3b), a clamp (25) for removably attaching the attachment device (10) to a putter (2), magnets (11a and 11b) located on the arms (3a and 3b) and guiding magnets (12a and 12b). The arms (3a and 3b) are located on each end of the putter head (9) during use. The guiding magnets (12a and 12b) are positioned such that they are substantially perpendicular to the putter head (9) and such that the electromagnetic field of each guiding magnets (12a and 12b) is facing towards the like electromagnetic field of each magnet (11a and 11b) located on the arms (3a and 3b) so as to create a repelling force (28).
    Type: Grant
    Filed: April 30, 2008
    Date of Patent: December 16, 2008
    Inventor: Robert H. Shoemaker
  • Patent number: 6987096
    Abstract: The present invention provides antiviral proteins (collectively referred to as cyanovirins), conjugates thereof, DNA sequences encoding such agents, host cells containing such DNA sequences, antibodies directed to such agents, compositions comprising such agents, and methods of obtaining and using such agents.
    Type: Grant
    Filed: November 13, 1997
    Date of Patent: January 17, 2006
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Michael R. Boyd, Kirk R. Gustafson, Robert H. Shoemaker, James B. McMahon
  • Patent number: 6245737
    Abstract: The present invention provides antiviral proteins, peptides and conjugates, as well as methods of obtaining these agents. The antiviral proteins, peptides and conjugates of the present invention can be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the infectivity, replication and cytopathic effects of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2, in the treatment or prevention of viral infection.
    Type: Grant
    Filed: August 19, 1998
    Date of Patent: June 12, 2001
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Michael R. Boyd, Kirk R. Gustafson, Robert H. Shoemaker, James B. McMahon
  • Patent number: 5998587
    Abstract: The present invention provides antiviral proteins (collectively referred to as cyanovirins), conjugates thereof, DNA sequences ending such agents, host cells containing such DNA sequences, antibodies directed to such agents, compositions comprising such agents, and methods of obtaining and using such agents.
    Type: Grant
    Filed: November 13, 1997
    Date of Patent: December 7, 1999
    Assignee: The United States of America, represented by the Secretary of the Department of Health and Human Services
    Inventors: Michael R. Boyd, Kirk R. Gustafson, Robert H. Shoemaker, James B. McMahon
  • Patent number: 5962668
    Abstract: The present invention provides antiviral proteins (collectively referred to as cyanovirins), conjugates thereof, DNA sequences encoding such agents, host cells containing such DNA sequences, antibodies directed to such agents, compositions comprising such agents, and methods of obtaining and using such agents.
    Type: Grant
    Filed: November 13, 1997
    Date of Patent: October 5, 1999
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Michael R. Boyd, Robert H. Shoemaker
  • Patent number: 5843882
    Abstract: The present invention provides antiviral proteins, peptides and conjugates, as well as methods of obtaining these agents. The antiviral proteins, peptides and conjugates of the present invention can be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the infectivity, replication and cytopathic effects of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2, in the treatment or prevention of viral infection.
    Type: Grant
    Filed: April 27, 1995
    Date of Patent: December 1, 1998
    Assignee: The United States of America as Represented by the Department of Health and Human Services
    Inventors: Michael R. Boyd, Kirk R. Gustafson, Robert H. Shoemaker, James B. McMahon
  • Patent number: 5821081
    Abstract: The present invention provides antiviral proteins (collectively referred to as cyanovirins), conjugates thereof, DNA sequences encoding such agents, host cells containing such DNA sequences, antibodies directed to such agents, compositions comprising such agents, and methods of obtaining and using such agents.
    Type: Grant
    Filed: April 26, 1996
    Date of Patent: October 13, 1998
    Assignee: The United States of Americaa as represented by the Secretary of the Department of Health and Human Services
    Inventors: Michael R. Boyd, Kirk R. Gustafson, Robert H. Shoemaker, James B. McMahon
  • Patent number: 4113511
    Abstract: A method and apparatus is disclosed where aqueous solutions of chemicals are added to fused non-aqueous baths. This is done by spraying the aqueous solution of the chemicals onto the surface of the fused bath in a fine spray, causing the evaporation of the water.
    Type: Grant
    Filed: January 17, 1977
    Date of Patent: September 12, 1978
    Inventors: Robert H. Shoemaker, William G. Wood
  • Patent number: 3951681
    Abstract: A ferrous metal product to be cleaned is immersed in an oxidizing molten salt bath forming a conditioned scale on the surface of the metal. The conditioned scale is subsequently removed from the metal surface by immersing the metal product in an aqueous caustic bath containing alkali metal hydroxide with alkali gluconate and triethanolamine serving as sequestering agents. The caustic bath may optionally include a brightening catalyst or ethylenediamine-tetracetic acid.
    Type: Grant
    Filed: November 1, 1973
    Date of Patent: April 20, 1976
    Assignee: Kolene Corporation
    Inventors: Robert H. Shoemaker, William G. Wood