Patents by Inventor Robert H. Terbrueggen
Robert H. Terbrueggen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 7935481Abstract: The present invention is directed to methods and compositions for the use of self-assembled monolayers to electronically detect nucleic acids, particularly alterations such as nucleotide substitutions (mismatches) and single nucleotide polymorphisms (SNPs).Type: GrantFiled: July 26, 2000Date of Patent: May 3, 2011Assignee: Osmetech Technology Inc.Inventors: Robert M. Umek, Gary Blackburn, Bruce D. Irvine, Robert H. Terbrueggen, Changjun Yu, Jost G. Vielmetter
-
Publication number: 20100028984Abstract: The invention is directed to a method of analyzing a plurality of biochips. In particular, the method includes inserting a first biochip in to a first station of an analysis device, inserting a second biochip into a second station of the analysis device, wherein each of the first and second biochips comprise a substrate that includes an array of detection electrodes, each including a different capture binding ligand, a different target analyte, and a label, and a plurality of electrical contacts, detecting current as an indication of the presence of the labels on the first biochip and detecting current as an indication of the presence of the labels on the second biochip.Type: ApplicationFiled: July 17, 2007Publication date: February 4, 2010Inventors: Hau H. DUONG, Gary Blackburn, Jon F. Kayyem, Stephen D. O'Connor, Gary T. Olsen, Robert Pietri, Robert H. Terbrueggen
-
Patent number: 7655129Abstract: The invention relates to compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly or indirectly, to allow electronic detection of the ETM.Type: GrantFiled: April 12, 2004Date of Patent: February 2, 2010Assignee: Osmetech Technology Inc.Inventors: Gary Blackburn, Stephen E. Creager, Scott Fraser, Bruce D. Irvine, Thomas J. Meade, Stephen J. O'Connor, Robert H. Terbrueggen, Jost G. Vielmetter, Thomas W. Welch
-
Patent number: 7312087Abstract: The invention is directed to devices and methods that allow for simultaneous multiple biochip analysis. The method of analyzing the plurality of biochips includes inserting a first biochp into a first station of an analysis device, inserting a second biochip into a second station of the analysis device, wherein each of the first and second biochips include a substrate, the substrates including an array of detection electrodes, each electrode including a different capture binding ligand, a different target analyte, and a label, and a plurality of electrical contracts, detecting current as an indication of the presence of the labels on the first biochip, and detecting current as an indication of the presence of the labels on the first second biochip. The devices and method may be used with multiple cartridges comprising biochips comprising arrays, such as nucleic acid arrays, and allow for high throughput analysis of samples.Type: GrantFiled: January 11, 2001Date of Patent: December 25, 2007Assignee: Clinical Micro Sensors, Inc.Inventors: Hau H. Duong, Gary Blackburn, Jon F. Kayyem, Stephen D. O'Connor, Gary T. Olsen, Robert Pietri, Robert H. Terbrueggen
-
Patent number: 6844399Abstract: Sulfonated substantially random interpolymers made from monomer components comprise from 1 to 65 mole percent of (a) at least one vinyl or vinylidene aromatic monomer, or (b) at least one hindered aliphatic or cycloaliphatic vinylidene monomer, or (c) a combination of at least one vinyl or vinylidene aromatic monomer and at lest one hindered aliphatic or cycloaliphatic vinylidene monomer, and from 35 to 99 mole percent of at least one aliphatic ?-olefin having from 2 to 20 carbon atoms; and optionally, from 0 to 20 mole percent of a diene containing from 4 to 20 carbon atoms; wherein the sulfonated interpolymer contains at least one mer (or moiety) of a group represented by the formula —SO3?M where M is hydrogen or a group 1, 7 or 12 metal in ionic form or combination thereof. Blends of these polymers with polyamides and polyolefins are made.Type: GrantFiled: October 7, 2002Date of Patent: January 18, 2005Assignee: Dow Global Technologies, Inc.Inventors: Yunwa W. Cheung, Stephen F. Hahn, James C. Stevens, Francis J. Timmers, Gregory F. Schmidt, Thoi H. Ho, Robert H. Terbrueggen
-
Publication number: 20040146909Abstract: The invention relates to the use of signal processing methods in order to acheive higher signal to noise ratios, to increase the detection limits of target analytes. These techniques include the monitoring of the output signal at higher harmonic frequencies.Type: ApplicationFiled: November 14, 2003Publication date: July 29, 2004Inventors: Hau H. Duong, Stephen D. O'Connor, Robert H. Terbrueggen, Jon Faiz Kayyem, Gary T. Olsen, Daniel A. Litvack, Javier Gonzalez
-
Patent number: 6761816Abstract: The invention relates to compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly or indirectly, to allow electronic detection of the ETM.Type: GrantFiled: March 8, 2000Date of Patent: July 13, 2004Assignee: Clinical Micro Systems, Inc.Inventors: Gary Blackburn, Stephen E. Creager, Scott Fraser, Bruce D. Irvine, Thomas J. Meade, Stephen D. O'Connor, Robert H. Terbrueggen, Jost G. Vielmetter, Thomas W. Welch
-
Patent number: 6740518Abstract: The invention relates to the use of signal processing methods in order to acheive higher signal to noise ratios, to increase the detection limits of target analytes. These techniques include the monitoring of the output signal at higher harmonic frequencies.Type: GrantFiled: September 17, 1999Date of Patent: May 25, 2004Assignee: Clinical Micro Sensors, Inc.Inventors: Hau H. Duong, Stephen D. O'Connor, Robert H. Terbrueggen, Jon Faiz Kayyem, Gary T. Olsen, Daniel A. Litvack, Javier Gonzalez
-
Patent number: 6686150Abstract: The invention relates to compositions and methods useful in the detection of nucleic acids using a variety of amplification techniques, including both signal amplification and target amplification. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the nucleic acid, either directly or indirectly, to allow electronic detection of the ETM using an electrode.Type: GrantFiled: July 20, 2000Date of Patent: February 3, 2004Assignee: Clinical Micro Sensors, Inc.Inventors: Gary Blackburn, Bruce D. Irvine, Jon Faiz Kayyem, Edward Lewis Sheldon, III, Robert H. Terbrueggen
-
Patent number: 6512049Abstract: Sulfonated substantially random interpolymers made from monomer components comprise from 1 to 65 mole percent of (a) at least one vinyl or vinylidene aromatic monomer, or (b) at least one hindered aliphatic or cycloaliphatic vinylidene monomer, or (c) a combination of at least one vinyl or vinylidene aromatic monomer and at lest one hindered aliphatic or cycloaliphatic vinylidene monomer, and from 35 to 99 mole percent of at least one aliphatic &agr;-olefin having from 2 to 20 carbon atoms; and optionally, from 0 to 20 mole percent of a diene containing from 4 to 20 carbon atoms; wherein the sulfonated interpolymer contains at least one mer (or moiety) of a group represented by the formula —SO3M where M is hydrogen or a group 1, 7 or 12 metal in ionic form or combination thereof. Blends of these polymers with polyamides and polyolefins are made.Type: GrantFiled: May 8, 2002Date of Patent: January 28, 2003Assignee: Dow Global Technologies Inc.Inventors: Yunwa W. Cheung, Stephen F. Hahn, James C. Stevens, Francis J. Timmers, Gregory F. Schmidt, Robert H. Terbrueggen, Thoi H. Ho
-
Publication number: 20020177135Abstract: The invention is directed to devices that allow for simultaneous multiple biochip analysis. In particular, the devices are configured to hold multiple cartridges comprising biochips comprising arrays such as nucleic acid arrays, and allow for high throughput analysis of samples.Type: ApplicationFiled: July 11, 2001Publication date: November 28, 2002Inventors: Hau H. Doung, Gary Blackburn, Jon F. Kayyem, Stephen D. O'Connor, Gary T. Olsen, Robert Pietri, Nathan Swami, Robert H. Terbrueggen
-
Patent number: 6479594Abstract: Sulfonated substantially random interpolymers made from monomer components comprise from 1 to 65 mole percent of (a) at least one vinyl or vinylidene aromatic monomer, or (b) at least one hindered aliphatic or cycloaliphatic vinylidene monomer, or (c) a combination of at least one vinyl or vinylidene aromatic monomer and at least one hindered aliphatic or cycloaliphatic vinylidene monomer, and from 35 to 99 mole percent of at least one aliphatic &agr;-olefin having from 2 to 20 carbon atoms; and optionally, from 0 to 20 mole percent of a diene containing from 4 to 20 carbon atoms; wherein the sulfonated interpolymer contains at least one mer (or moiety) of a group represented by the formula —SO3−M where M is hydrogen or a group 1, 7 or 12 metal in ionic form or combination thereof. Blends of these polymers with polyamides and polyolefins are made.Type: GrantFiled: April 20, 2000Date of Patent: November 12, 2002Assignee: The Dow Chemical CompanyInventors: Yunwa W. Cheung, Stephen F. Hahn, James C. Stevens, Francis J. Timmers, Gregory F. Schmidt, Thoi H. Ho, Robert H. Terbrueggen
-
Publication number: 20020042488Abstract: Novel substantially random functionalized interpolymers and processes for making them are disclosed. The novel interpolymers include those prepared from ethylene and vinyl aromatic monomers such as ethylene-styrene interpolymers which are then functionalized with a variety of electrophilic and nucleophilic reagents.Type: ApplicationFiled: January 10, 2001Publication date: April 11, 2002Inventors: Ray E. Drumright, Robert H. Terbrueggen, Kenneth A. Burdett, Francis J. Timmers, Stephen F. Hahn
-
Publication number: 20020037988Abstract: Novel substantially random functionalized interpolymers and processes for making them are disclosed. The novel interpolymers include those prepared from ethylene and vinyl aromatic monomers such as ethylene-styrene interpolymers which are then functionalized with a variety of electrophilic and nucleophilic reagents.Type: ApplicationFiled: October 10, 2001Publication date: March 28, 2002Inventors: Ray E. Drumright, Robert H. Terbrueggen, Kenneth A. Burdett, Francis J. Timmers, Stephen F. Hahn
-
Patent number: 6325956Abstract: The invention includes a process comprising (a) forming a polymeric admixture including at least one polyolefin which has been prepared using a single site catalyst and at least a crosslinking amount of at least one poly(sulfonyl azide) crosslinking agent; (b) shaping the resulting admixture; and (c) heating the resulting shaped admixture to a temperature at least the decomposition temperature of the crosslinking agent. The steps take place in any sequence and optionally include substeps. The single site catalyst is preferably a constrained geometry or metallocene catalyst, but optionally another transition metal catalyst which is not a traditional Ziegler Natta Ti/MgCl2 catalyst such as a vanadium catalyst. The invention further includes all compositions obtainable by the process of the invention as well as all articles formed from these compositions.Type: GrantFiled: August 26, 1998Date of Patent: December 4, 2001Assignee: The Dow Chemical CompanyInventors: Bharat I. Chaudhary, Thoi H. Ho, Seema V. Karande, Che-I. Kao, Robert H. Terbrueggen, David A. Babb, Clark H. Cummins, Michael J. Mullins, H. Craig Silvis
-
Patent number: 6313252Abstract: Novel substantially random functionalized interpolymers and processes for making them are disclosed. The novel interpolymers include those prepared from ethylene and vinyl aromatic monomers such as ethylene-styrene interpolymers which are then functionalized with a variety of electrophilic and nucleophilic reagents.Type: GrantFiled: February 4, 1999Date of Patent: November 6, 2001Assignee: The Dow Chemical CompanyInventors: Ray E. Drumright, Robert H. Terbrueggen, Kenneth A. Burdett, Francis J. Timmers, Stephen F. Hahn
-
Patent number: 6284842Abstract: The invention includes a process of preparing a coupled polymer blend comprising heating an admixture containing (1) a polymer blend containing: (A) from 1 to 99 weight percent of one ore more &agr;-olefin/hindered vinyl monomer substantially random interpolymers, each having been made from monomer components comprising: (1) from 0.5 to 65 mole percent of either (a) at least one vinyl aromatic monomer, or (b) at least one hindered aliphatic vinyl monomer, or (c) a combination of at least one vinyl aromatic monomer and at least one hindered aliphatic vinyl monomer; and (2) from 35 to 99.Type: GrantFiled: August 26, 1998Date of Patent: September 4, 2001Assignee: The Dow Chemical companyInventors: Thoi H. Ho, Robert H. Terbrueggen, H. Craig Silvis, Clark H. Cummins, Michael J. Mullins
-
Patent number: 6277916Abstract: This invention includes a process for forming a thermoplastic vulcanizate comprising: (a) admixing a C—H insertion curing agent with at least one elastomeric phase polymer to form a first admixture; (b) admixing at least one non-elastomeric polyolefin with the first admixture to form a second admixture; and (c) heating the second admixture to a temperature at least the decomposition temperature of the curing agent to crosslink the elastomeric phase while mixing the admixture to an extent sufficient to result in the formation of a thermoplastic material, hereinafter referred to as a thermoplastic vulcanizate, and optionally including an additional step (d) of shaping the resulting thermoplastic vulcanizate, especially by heating and foaming or molding the TPV.Type: GrantFiled: February 25, 1999Date of Patent: August 21, 2001Assignee: The Dow Chemical CompanyInventors: Robert H. Terbrueggen, Ray E. Drumright, Thoi H. Ho
-
Patent number: 6264825Abstract: The invention relates to compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly or indirectly, to allow electronic detection of the ETM.Type: GrantFiled: June 23, 1999Date of Patent: July 24, 2001Assignee: Clinical Micro Sensors, Inc.Inventors: Gary Blackburn, Stephen E. Creager, Scott Fraser, Bruce D. Irvine, Thomas J. Meade, Stephen D. O'Connor, Robert H. Terbrueggen, Jost G. Vielmetter, Thomas W. Welch
-
Publication number: 20010002075Abstract: The invention includes a process comprising (a) forming a polymeric admixture including at least one polyolefin which has been prepared using a single site catalyst and at least a crosslinking amount of at least one poly(sulfonyl azide) crosslinking agent; (b) shaping the resulting admixture; and (c) heating the resulting shaped admixture to a temperature at least the decomposition temperature of the crosslinking agent. The steps take place in any sequence and optionally include substeps. The single site catalyst is preferably a constrained geometry or metallocene catalyst, but optionally another transition metal catalyst which is not a traditional Ziegler Natta Ti/MgCl2 catalyst such as a vanadium catalyst.Type: ApplicationFiled: August 26, 1998Publication date: May 31, 2001Inventors: BHARAT CHAUDHARY, THOI H. HO, SEEMA KARANDE, CHE-I KAO, ROBERT H. TERBRUEGGEN, DAVID A. BABB, CLARK H. CUMMINS, MICHAEL J. MULLINS, H. CRAIG SILVIS