Patents by Inventor Robert H. Weiss

Robert H. Weiss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sorafenib derivatives as p21 inhibitors
    Patent number: 10449182
    Abstract: The present invention provides sorafenib analogs for use in a method of treating a disease mediated by p21, said method comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula I. The present invention also provides methods of inhibiting p21 in a cell comprising contacting the cell with an effective amount of a compound of formula I.
    Type: Grant
    Filed: June 20, 2013
    Date of Patent: October 22, 2019
    Assignee: The Regents of the University of California
    Inventors: Robert H. Weiss, Bruce D. Hammock, Hiromi Inoue Wettersten, Sung Hee Hwang
  • SORAFENIB DERIVATIVES AS P21 INHIBITORS
    Publication number: 20150132408
    Abstract: The present invention provides sorafenib analogs for use in a method of treating a disease mediated by p21, said method comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula I. The present invention also provides methods of inhibiting p21 in a cell comprising contacting the cell with an effective amount of a compound of formula I.
    Type: Application
    Filed: June 20, 2013
    Publication date: May 14, 2015
    Inventors: Robert H. Weiss, Bruce D. Hammock, Hiromi Inoue, Sung Hee Hwang
  • Novel specific inhibitor of the cyclin kinase inhibitor p21 (wafl/cip1)
    Publication number: 20030144236
    Abstract: Methods and compositions for regulating abnormal cell growth and proliferation mediated by p21Waf1/Cip1 using inhibitors of p21Waf1/CiP1.
    Type: Application
    Filed: September 26, 2002
    Publication date: July 31, 2003
    Inventor: Robert H Weiss
  • Use of inhibitors of soluble epoxide hydrolase to inhibit vascular smooth muscle cell proliferation
    Publication number: 20030139469
    Abstract: The present invention provides methods of slowing or inhibiting vascular smooth muscle (VSM) cell proliferation to slow the development or recurrence of atherosclerosis by contacting VSM cells with soluble epoxide hydrolase (sEH) inhibitors. Further, the methods of the invention can be used to slow or to inhibit vascular restenosis after angioplasty and the stenosis of vascular stents. Further, the methods of the invention can be used to slow or to inhibit the stenosis of hemodialysis grafts and other natural and synthetic vascular grafts.
    Type: Application
    Filed: January 23, 2002
    Publication date: July 24, 2003
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Robert H. Weiss, Bruce D. Hammock