Abstract: Systems and methods for generating neuroprotective and cardioprotective nutrition programs are described herein. These neuroprotective and cardioprotective nutrition programs are especially applicable for patients at risk of cardiac arrest (e.g. due to hypoxia or ischemia of the brain or other body parts). The programs may feature caloric restriction, for example, short-term caloric restriction. The programs may be generated or iteratively modified based on the hemodynamic and metabolic state of the patient's brain, limbs, or other tissues or organs. Dynamic feedback about the patient's hemodynamic and metabolic state may be provided by techniques including, but not limited to, optical technology for quantitatively and noninvasively measuring blood flow, oxygenation, metabolic rate of oxygen, and perfusion/metabolism ratio in the brain, limbs, or other tissues or organs.

Abstract: Systems and methods for generating neuroprotective and cardioprotective nutrition programs are described herein. These neuroprotective and cardioprotective nutrition programs are especially applicable for patients at risk of cardiac arrest (e.g. due to hypoxia or ischemia of the brain or other body parts). The programs may feature caloric restriction, for example, short-term caloric restriction. The programs may be generated or iteratively modified based on the hemodynamic and metabolic state of the patient's brain, limbs, or other tissues or organs. Dynamic feedback about the patient's hemodynamic and metabolic state may be provided by techniques including, but not limited to, optical technology for quantitatively and noninvasively measuring blood flow, oxygenation, metabolic rate of oxygen, and perfusion/metabolism ratio in the brain, limbs, or other tissues or organs.

Abstract: A multimodal optical imaging platform is used to obtain cerebral perfusion-metabolism mismatch metrics for rapid assessment of acute brain injury, ongoing (real-time) feedback to optimize cardiopulmonary resuscitation to improve neurological outcome, and rapid prognosis of recovery. Light of several wavelengths and types is delivered to the tissue, which is then absorbed and scattered by tissue components such as blood and cellular components. Some of this light scatters back to the surface, where it is captured by a detector. The resulting data are processed to obtain blood flow and oxygenation parameters, as well as tissue scattering. These parameters are then combined to calculate metabolism and flow-metabolism coupling/decoupling metrics, which are used to determine ischemic damage, ongoing need for optimal blood flow and oxygenation, and to predict cerebral recovery in patients with acute brain injury during and immediately after cardiac arrest, stroke, traumatic brain injury, etc.

Abstract: A multimodal optical imaging platform is used to obtain cerebral perfusion-metabolism mismatch metrics for rapid assessment of acute brain injury, ongoing (real-time) feedback to optimize cardiopulmonary resuscitation to improve neurological outcome, and rapid prognosis of recovery. Light of several wavelengths and types is delivered to the tissue, which is then absorbed and scattered by tissue components such as blood and cellular components. Some of this light scatters back to the surface, where it is captured by a detector. The resulting data are processed to obtain blood flow and oxygenation parameters, as well as tissue scattering. These parameters are then combined to calculate metabolism and flow-metabolism coupling/decoupling metrics, which are used to determine ischemic damage, ongoing need for optimal blood flow and oxygenation, and to predict cerebral recovery in patients with acute brain injury during and immediately after cardiac arrest, stroke, traumatic brain injury, etc.

Abstract: Electrophysiologic biomarkers for prognostication of neurological outcome are described herein. An inverse correlation was found between timing of a cortical spreading depolarization (SD) wave and neurological outcome as tested at 24 hours post-CPR. Additionally, a minor image of this SD was identified as a “repolarization (RP) wave.” Quantifying features of SD and RP during cardiac arrest and cardiopulmonary resuscitation (CPR) provide important metrics for diagnosis and prognosis of neurological injury from hypoxia-ischemia and can serve as an early prognostication tool for predicting outcome at subsequent days after successful CPR. This discovery may also allow for novel therapeutic interventions to improve neurological recovery after hypoxia-ischemia insults.

Abstract: A portable device for quantitative measurement of tissue autoregulation and neurovascular coupling via portable measurement of blood flow, oxygenation, metabolism, and/or EEG signals and methods for using said device. The device may comprise a body and a plurality of legs pivotably attached to the body. The plurality of legs may comprise at least one reference electrode leg and at least one measurement electrode leg for electrical measurement, and an optical detection fiber leg and at least one optical source fiber leg for optical blood flow, oxygenation, and metabolism measurement. The present invention is additionally directed to a portable device for blood flow measurement and therapeutic photobiomodulation. The device may comprise a body and a plurality of legs. The plurality of legs may comprise at least one optical detection fiber leg and at least one optical source fiber leg, and at least one leg for therapeutic photobiomodulation.

Abstract: The present invention is directed to a portable device for quantitative measurement of tissue autoregulation and neurovascular coupling via portable measurement of blood flow, oxygenation, metabolism, and/or EEG signals and methods for using said device. The device may comprise a body and a plurality of legs pivotably attached to the body. The plurality of legs may comprise at least one reference electrode leg and at least one measurement electrode leg for electrical measurement, and an optical detection fiber leg and at least one optical source fiber leg for optical blood flow, oxygenation, and metabolism measurement. The present invention is additionally directed to a portable device for blood flow measurement and therapeutic photobiomodulation. The device may comprise a body and a plurality of legs. The plurality of legs may comprise at least one optical detection fiber leg and at least one optical source fiber leg, and at least one leg for therapeutic photobiomodulation.

Abstract: A tetrahedron shaped pipe section core connector and an optional end connector that enable the quick fabrication of a stable tripod base with a stable post support. The core connector is made by machining, molding, casting, or forging the material from which the pipe connector is constructed (typically metal or plastic). The core component (hereinafter the “knuckle connector”) provides four pipe connections oriented at 109.5° angles to each other, forming a regular tetrahedron shape. Pipe sections may be screwed or press fit into each of the four pipe connections. Three of these fitted pipes may be oriented to form a tripod base. The remaining pipe connection extends vertically up to form a post support. The body of the knuckle connector optionally incorporates one or more smaller apertures, preferably threaded, that extend through the wall of the body of the connector. These apertures provide attachment points for ancillary components.

Abstract: Multimodal optical spectroscopy systems and methods produce a spectroscopic event to obtain spectroscopic response data from biological tissue, either ex vivo or in vivo, and compare the response data with a model configured to correlate the measured response data and the most probable attributes of the tissue, thus facilitating classification of the tissue based on those attributes.

Abstract: Multimodal optical spectroscopy systems and methods produce a spectroscopic event to obtain spectroscopic response data from biological tissue, either ex vivo or in vivo, and compare the response data with a model configured to correlate the measured response data and the most probable attributes of the tissue, thus facilitating classification of the tissue based on those attributes.

Abstract: Multimodal optical spectroscopy systems and methods produce a spectroscopic event to obtain spectroscopic response data from biological tissue and compare the response data with preset criteria configured to correlate the measured response data and the most probable attributes of the tissue, thus facilitating classification of the tissue based on those attributes for subsequent biopsy or remedial measures as necessary.

Abstract: Multimodal optical spectroscopy systems and methods produce a spectroscopic event to obtain spectroscopic response data from biological tissue and compare the response data with an empirical equation configured to correlate the measured response data and the most probable attributes of the tissue, thus facilitating classification of the tissue based on those attributes for subsequent biopsy or remedial measures as necessary.

Abstract: Multimodal optical spectroscopy systems and methods produce a spectroscopic event to obtain spectroscopic response data from biological tissue and compare the response data with an empirical equation configured to correlate the measured response data and the most probable attributes of the tissue, thus facilitating classification of the tissue based on those attributes for subsequent biopsy or remedial measures as necessary.

Abstract: A system for the wireless activation or deactivation of one or more switches associated with one or more communication indicators within an industrial or professional working environment. The system includes at least one portable, handheld transmitter comprising at least one manually operated switch and a signal transmitter. Further included is at least one fixed indicator assembly comprising a signal receiver, at least one automatically operational switch, and at least one indicator capable of audibly or visually communicating a condition to workers within the industrial or professional working environment. The wireless indicator switch system is a highly flexible combination of a lightweight, small key fob type transmitter paired with a flexible receiver circuit board for controlling a variety of industrial and/or professional working environment indication devices.

Abstract: Multimodal optical spectroscopy systems and methods produce a spectroscopic event to obtain spectroscopic response data from biological tissue and compare the response data with preset criteria configured to correlate the measured response data and the most probable attributes of the tissue, thus facilitating classification of the tissue based on those attributes for subsequent biopsy or remedial measures as necessary.

Abstract: A mid-sized firefighting and fire rescue vehicle capable of accessing a range of off-road wildland environments that is also “street legal” for rapid on-road transportation. The vehicle is configured to be outfitted as needed with any of a variety of different firefighting or fire rescue systems packaged as removable modules, fixed in place in the bed of the vehicle. The vehicle achieves stability and ruggedness through the use of three military type axles, two of which (the rear axles) are both drive axles. The vehicle is further configured with an open bed structured to receive, position, and retain an integrated, modularly structured, firefighting or fire rescue system in such a manner as may be switched out with alternate systems as required for the type of service into which the vehicle is called.

Abstract: A universal garage door operating system and method. In one embodiment, a vehicle transmitter is provided transmitting a wireless garage door transmitter control signal. A control module is provided for mounting in a structure such as a garage, and is adapted to receive a wireless garage door transmitter. The control module includes a receiver for receiving the garage door transmitter control signal, a controller for generating a garage door transmitter actuator control signal in response to the garage door transmitter control signal, and an actuator for actuating the garage door transmitter in response to the garage door actuator control signal so that the garage door transmitter transmits a wireless garage door control signal for use in operating a garage door.

Abstract: A universal garage door operating system and method. In one embodiment, a vehicle transmitter is provided transmitting a wireless garage door transmitter control signal. A control module is provided for mounting in a structure such as a garage, and is adapted to receive a wireless garage door transmitter. The control module includes a receiver for receiving the garage door transmitter control signal, a controller for generating a garage door transmitter actuator control signal in response to the garage door transmitter control signal, and an actuator for actuating the garage door transmitter in response to the garage door actuator control signal so that the garage door transmitter transmits a wireless garage door control signal for use in operating a garage door.

Abstract: A portable wireless andon communication system and method for use in manufacturing, assembly and other industrial settings. A transmitter station and receiver station are set up for immediate use by simply connecting each to a standard power source. A user needing assistance manually activates a switch at the transmitter station, thus turning on a light and transmitting a corresponding signal to the receiver station. The receiver station receives the signal and turns on a corresponding light and tone generator. The tone generator and light alert indicate to the proper parties the request for a response. A responding party scans transmitter stations for the corresponding light and provides assistance. The switch may be a sensor activated by a change in state indicating that assistance is required. The portable system is easily reconfigured if necessitated by layout changes in a manufacturing line.