Abstract: Disclosed are 1-arylamino-phthalazines, 4-arylamino-benzo[d][1,2,3]triazines, and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

Abstract: An apparatus is provided for a bicycle lock assembly. A housing has an annular outer wall with a cable access slot and an integral rear wall. The rear wall supports a tubular inner wall that extends from the rear wall coaxially with the outer wall to define a torus shaped interior space. A reel provides a tubular core that is rotatably mounted onto the inner wall. The core supports a pair of spaced-apart guide walls which define a coiling space therebetween. A flexible cable is wound onto the reel between the guide walls. One end of the cable is fixed to the core. The other end of the cable extends through the access slot and includes a first lock mechanism. A coil spring has one end fixed to the annular outer wall and the other end fixed to the core of the reel. The spring lays in a spiral form adjacent to one of the guide walls such that rotation of the reel to unreel the cable causes the coil spring to tighten. Similarly, rotation of the reel to reel-in the cable causes the coil spring to loosen.