Patents by Inventor Robert Haselbeck

Robert Haselbeck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Microorganisms for the production of 1,4- butanediol and related methods
    Patent number: 11401534
    Abstract: The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO.
    Type: Grant
    Filed: March 6, 2019
    Date of Patent: August 2, 2022
    Assignee: Genomatica, Inc.
    Inventors: Stephen J. Van Dien, Anthony P. Burgard, Robert Haselbeck, Catherine J. Pujol-Baxley, Wei Niu, John D. Trawick, Harry Yim, Mark J. Burk, Robin E. Osterhout, Jun Sun
  • Microorganisms and methods for the coproduction 1,4-butanediol and gamma-butyrolactone
    Patent number: 10662451
    Abstract: The invention provides non-naturally occurring microbial organisms comprising 1,4-butanediol (14-BDO) and gamma-butyrolactone (GBL) pathways comprising at least one exogenous nucleic acid encoding a 14-BDO and GBL pathway enzyme expressed in a sufficient amount to produce 14-BDO and GBL. The invention additionally provides methods of using such microbial organisms to produce 14-BDO and GBL.
    Type: Grant
    Filed: May 4, 2018
    Date of Patent: May 26, 2020
    Assignee: Genomatica, Inc.
    Inventors: Jun Sun, Mark J. Burk, Anthony P. Burgard, Robin E. Osterhout, Wei Niu, John D. Trawick, Robert Haselbeck
  • MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL AND RELATED METHODS
    Publication number: 20190376095
    Abstract: The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO.
    Type: Application
    Filed: March 6, 2019
    Publication date: December 12, 2019
    Inventors: Stephen J. Van Dien, Anthony P. Burgard, Robert Haselbeck, Catherine J. Pujol-Baxley, Wei Niu, John D. Trawick, Harry Yim, Mark J. Burk, Robin E. Osterhout, Jun Sun
  • MICROORGANISMS AND METHODS FOR THE COPRODUCTION 1,4-BUTANEDIOL AND GAMMA-BUTYROLACTONE
    Publication number: 20190276863
    Abstract: The invention provides non-naturally occurring microbial organisms comprising 1,4-butanediol (14-BDO) and gamma-butyrolactone (GBL) pathways comprising at least one exogenous nucleic acid encoding a 14-BDO and GBL pathway enzyme expressed in a sufficient amount to produce 14-BDO and GBL. The invention additionally provides methods of using such microbial organisms to produce 14-BDO and GBL.
    Type: Application
    Filed: May 4, 2018
    Publication date: September 12, 2019
    Inventors: Jun Sun, Mark J. Burk, Anthony P. Burgard, Robin E. Osterhout, Wei Niu, John D. Trawick, Robert Haselbeck
  • MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL, 4-HYDROXYBUTANAL, 4-HYDROXYBUTYRYL-COA, PUTRESCINE AND RELATED COMPOUNDS, AND METHODS RELATED THERETO
    Publication number: 20190264240
    Abstract: The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine.
    Type: Application
    Filed: December 11, 2018
    Publication date: August 29, 2019
    Inventors: Robert Haselbeck, John D. Trawick, Wei Niu, Anthony P. Burgard
  • Microorganisms for the production of 1,4-butanediol and related methods
    Patent number: 10273508
    Abstract: The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: April 30, 2019
    Assignee: Genomatica, Inc.
    Inventors: Stephen J. Van Dien, Anthony P. Burgard, Robert Haselbeck, Catherine J. Pujol-Baxley, Wei Niu, John D. Trawick, Harry Yim, Mark J. Burk, Robin E. Osterhout, Jun Sun
  • Microorganisms and methods for the coproduction 1,4-butanediol and gamma-butyrolactone
    Patent number: 9988656
    Abstract: The invention provides non-naturally occurring microbial organisms comprising 1,4-butanediol (14-BDO) and gamma-butyrolactone (GBL) pathways comprising at least one exogenous nucleic acid encoding a 14-BDO and GBL pathway enzyme expressed in a sufficient amount to produce 14-BDO and GBL. The invention additionally provides methods of using such microbial organisms to produce 14-BDO and GBL.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: June 5, 2018
    Assignee: Genomatica, Inc.
    Inventors: Jun Sun, Mark J. Burk, Anthony P. Burgard, Robin E. Osterhout, Wei Niu, John D. Trawick, Robert Haselbeck
  • MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL, 4-HYDROXYBUTANAL, 4-HYDROXYBUTYRYL-COA, PUTRESCINE AND RELATED COMPOUNDS, AND METHODS RELATED THERETO
    Publication number: 20160376614
    Abstract: The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine.
    Type: Application
    Filed: June 3, 2016
    Publication date: December 29, 2016
    Inventors: Robert HASELBECK, John D. TRAWICK, Wei NIU, Anthony P. BURGARD
  • MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL AND RELATED METHODS
    Publication number: 20160355846
    Abstract: The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO.
    Type: Application
    Filed: May 6, 2016
    Publication date: December 8, 2016
    Inventors: Stephen J. VAN DIEN, Anthony P. BURGARD, Robert HASELBECK, Catherine J. PUJOL-BAXLEY, Wei NIU, John D. TRAWICK, Harry YIM, Mark J. BURK, Robin E. OSTERHOUT, Jun SUN
  • MICROORGANISMS AND METHODS FOR THE COPRODUCTION 1,4-BUTANEDIOL AND GAMMA-BUTYROLACTONE
    Publication number: 20160319313
    Abstract: The invention provides non-naturally occurring microbial organisms comprising 1,4-butanediol (14-BDO) and gamma-butyrolactone (GBL) pathways comprising at least one exogenous nucleic acid encoding a 14-BDO and GBL pathway enzyme expressed in a sufficient amount to produce 14-BDO and GBL. The invention additionally provides methods of using such microbial organisms to produce 14-BDO and GBL.
    Type: Application
    Filed: November 30, 2015
    Publication date: November 3, 2016
    Inventors: Jun SUN, Mark J. BURK, Anthony P. BURGARD, Robin E. OSTERHOUT, Wei NIU, John D. TRAWICK, Robert HASELBECK
  • Microorganisms for the production of 1,4-butanediol and related methods
    Patent number: 9434964
    Abstract: The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO.
    Type: Grant
    Filed: January 30, 2012
    Date of Patent: September 6, 2016
    Assignee: Genomatica, Inc.
    Inventors: Stephen J. Van Dien, Anthony P. Burgard, Robert Haselbeck, Catherine J. Pujol-Baxley, Wei Niu, John D. Trawick, Harry Yim, Mark J. Burk, Robin E. Osterhout, Jun Sun
  • Microorganisms and methods for the coproduction 1,4-butanediol and gamma-butyrolactone
    Patent number: 9222113
    Abstract: The invention provides non-naturally occurring microbial organisms comprising 1,4-butanediol (14-BDO) and gamma-butyrolactone (GBL) pathways comprising at least one exogenous nucleic acid encoding a 14-BDO and GBL pathway enzyme expressed in a sufficient amount to produce 14-BDO and GBL. The invention additionally provides methods of using such microbial organisms to produce 14-BDO and GBL.
    Type: Grant
    Filed: July 8, 2013
    Date of Patent: December 29, 2015
    Assignee: Genomatica, Inc.
    Inventors: Jun Sun, Mark J. Burk, Anthony P. Burgard, Robin E. Osterhout, Wei Niu, John D. Trawick, Robert Haselbeck
  • MICROORGANISMS AND METHODS FOR THE COPRODUCTION 1,4-BUTANEDIOL AND GAMMA-BUTYROLACTONE
    Publication number: 20140162327
    Abstract: The invention provides non-naturally occurring microbial organisms comprising 1,4-butanediol (14-BDO) and gamma-butyrolactone (GBL) pathways comprising at least one exogenous nucleic acid encoding a 14-BDO and GBL pathway enzyme expressed in a sufficient amount to produce 14-BDO and GBL. The invention additionally provides methods of using such microbial organisms to produce 14-BDO and GBL.
    Type: Application
    Filed: July 8, 2013
    Publication date: June 12, 2014
    Inventors: JUN SUN, MARK J. BURK, ANTHONY P. BURGARD, ROBIN E. OSTERHOUT, WEI NIU, JOHN D. TRAWICK, ROBERT HASELBECK
  • Microorganisms and methods for the coproduction 1,4-butanediol and gamma-butyrolactone
    Patent number: 8530210
    Abstract: The invention provides non-naturally occurring microbial organisms comprising 1,4-butanediol (14-BDO) and gamma-butyrolactone (GBL) pathways comprising at least one exogenous nucleic acid encoding a 14-BDO and GBL pathway enzyme expressed in a sufficient amount to produce 14-BDO and GBL. The invention additionally provides methods of using such microbial organisms to produce 14-BDO and GBL.
    Type: Grant
    Filed: November 4, 2010
    Date of Patent: September 10, 2013
    Assignee: Genomatica, Inc.
    Inventors: Jun Sun, Mark J. Burk, Anthony P. Burgard, Robin E. Osterhout, Wei Niu, John D. Trawick, Robert Haselbeck
  • MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL, 4-HYDROXYBUTANAL, 4-HYDROXYBUTYRYL-COA, PUTRESCINE AND RELATED COMPOUNDS, AND METHODS RELATED THERETO
    Publication number: 20130189751
    Abstract: The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine.
    Type: Application
    Filed: January 9, 2013
    Publication date: July 25, 2013
    Applicant: Genomatica, Inc.
    Inventors: Robert HASELBECK, John D. TRAWICK, Wei NIU, Anthony P. BURGARD
  • Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA, putrescine and related compounds, and methods related thereto
    Patent number: 8377667
    Abstract: The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine.
    Type: Grant
    Filed: May 17, 2011
    Date of Patent: February 19, 2013
    Assignee: Genomatica, Inc.
    Inventors: Robert Haselbeck, John D. Trawick, Wei Niu, Anthony P. Burgard
  • Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-coa, putrescine and related compounds, and methods related thereto
    Patent number: 8377666
    Abstract: The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine.
    Type: Grant
    Filed: October 13, 2010
    Date of Patent: February 19, 2013
    Assignee: Genomatica, Inc.
    Inventors: Robert Haselbeck, John D. Trawick, Wei Niu, Anthony P. Burgard
  • MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL, 4-HYDROXYBUTANAL, 4-HYDROXYBUTYRYL-COA, PUTRESCINE AND RELATED COMPOUNDS, AND METHODS RELATED THERETO
    Publication number: 20130029381
    Abstract: The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine.
    Type: Application
    Filed: April 13, 2012
    Publication date: January 31, 2013
    Applicant: GENOMATICA, INC.
    Inventors: Robert Haselbeck, John D. Trawick, Wei Niu, Anthony P. Burgard
  • Identification and application of antibiotic synergy
    Patent number: 8298543
    Abstract: The present invention provides a pharmaceutical composition useful for treating bacterial infections in humans and animals which comprises administering to a human or animal in need thereof, an antibacterially effective combination of a ?-lactam antibiotic and an inhibitor of any bacterial peptidoglycan biosynthesis enzyme, especially GlmU, GlmU, MurA, MurB, MurC, MurD, MurE, MurF, MurG, MraY, and UppS.
    Type: Grant
    Filed: May 6, 2011
    Date of Patent: October 30, 2012
    Assignee: Trius Therapeutics, Inc.
    Inventors: Vickie Brown-Driver, Kedar GC, John M. Finn, Robert Haselbeck, Mark Hilgers, Karen Shaw, Mark Stidham
  • MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL AND RELATED METHODS
    Publication number: 20120225463
    Abstract: The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO.
    Type: Application
    Filed: January 30, 2012
    Publication date: September 6, 2012
    Applicant: Genomatica, Inc.
    Inventors: Stephen J. Van Dien, Anthony P. Burgard, Robert Haselbeck, Catherine J. Pujol-Baxley, Wei Niu, John D. Trawick, Harry Yim, Mark J. Burk, Robin E. Osterhout, Jun Sun