Abstract: The present disclosure provides a HTP genomic engineering platform for improving Escherichia coli. that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols. This integrative platform utilizes a suite of HTP molecular tool sets to create HTP genetic design libraries, which are derived from, inter alia, scientific insight and iterative pattern recognition.

Abstract: A microcontact printing device including a tube member for storing or transferring a printing fluid or liquid and a printing element attached to an end of the fluid dispensing member. Further, a microcontact printhead device including a holder and at least one microcontact printing device disposed within the holder, the microcontact printing device including a tube member for storing or transferring a printing fluid or liquid and a printing element attached to an end of the fluid dispensing member. In addition, a method of fabricating a microcontact printing device including providing a wafer or substrate, micromachining a printing element from the wafer or substrate, providing a tube member for storing or transferring a printing fluid or liquid, and attaching the printing element to an end of the tube member.

Abstract: A microcontact printing pin for depositing a liquid on a substrate includes a printing tip at a first end and a reservoir, which holds a supply of a printing fluid, communicating with the printing tip. A fluid delivery channel extends between the reservoir and the printing tip and the channel has a tapered shape decreasing in width from the reservoir to the printing tip. This tapered shape ensures that the delivery of the printing fluid to the printing tip is smooth, accurate and controllable. The printing tip portion may also be thinned so that the printing tip portion is thinner than the portion provided with the reservoir and a stepped portion between the reservoir and the thinned printing tip portion that eliminates prespotting.

Abstract: The present invention provides systems and methods for dispensing portions of viscous material, such as the viscous materials used to form crystals of membrane proteins or soluble proteins. A liquid under pressure is used to divide the viscous material into portions.

Abstract: The present invention relates generally to encoding samples. More specifically, it relates to barcodes and compositions involving upconverters and methods including them. In a composition aspect of the invention, a composition comprising two or more lanthanide materials is provided. Each lanthanide material comprises a host, an absorber, and an emitter, and the materials emit detectable electromagnetic radiation upon excitation with absorbable electromagnetic energy. One or more relative ratios of emission intensities uniquely identify the composition.