Patents by Inventor Robert Havener
Robert Havener has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240081323Abstract: An ex-vivo lung solution for machine perfusion of donor lungs on OCS. The solution may be mixed with whole blood or packed red blood cells to form the OCS lung perfusion solution.Type: ApplicationFiled: November 17, 2023Publication date: March 14, 2024Inventors: Waleed H. HASSANEIN, Ihab Abdel FATTAH, Paul LEZBERG, Tamer I. KHAYAL, Robert HAVENER, Anas ABDELAZIM
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Patent number: 11917991Abstract: Electrode systems have been developed for use in perfusion systems to measure the electrical activity of an explanted heart and to provide defibrillation energy as necessary. The perfusion systems maintain the heart in a beating state at, or near, normal physiological conditions; circulating oxygenated, nutrient enriched perfusion fluid to the heart at or near physiological temperature, pressure and flow rate. These systems include a pair of electrodes that are placed epicardially on the right atrium and left ventricle of the explanted heart, as well as an electrode placed in the aortic blood path.Type: GrantFiled: May 21, 2019Date of Patent: March 5, 2024Assignee: TRANSMEDICS, INC.Inventors: Waleed H. Hassanein, Ahmed Elbetanony, Richard Bringham, Robert Havener, Vincent Lambert, II, Burt Ochs
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Patent number: 11856944Abstract: An ex-vivo lung solution for machine perfusion of donor lungs on OCS. The solution may be mixed with whole blood or packed red blood cells to form the OCS lung perfusion solution.Type: GrantFiled: July 20, 2022Date of Patent: January 2, 2024Assignee: TRANSMEDICS, INC.Inventors: Waleed H. Hassanein, Ihab Abdel Fattah, Paul Lezberg, Tamer I. Khayal, Robert Havener, Anas Abdelazim
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Publication number: 20220361482Abstract: An ex-vivo lung solution for machine perfusion of donor lungs on OCS. The solution may be mixed with whole blood or packed red blood cells to form the OCS lung perfusion solution.Type: ApplicationFiled: July 20, 2022Publication date: November 17, 2022Inventors: Waleed H. HASSANEIN, Ihab Abdel FATTAH, Paul LEZBERG, Tamer I. KHAYAL, Robert HAVENER, Anas ABDELAZIM
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Publication number: 20200352155Abstract: Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.Type: ApplicationFiled: July 30, 2020Publication date: November 12, 2020Inventors: Robert FISHMAN, Robert HAVENER, Ihab Abdel FATTAH, Anas ABDELAZIM, Scott NEWELL, Thomas H. BISHOP, Tamer I. KHAYAL, Stanley KYI, Ronald TAYLOR, JR., Doug HARRIOTT, Matthew DE REMER, Paul MURRAY, John SULLIVAN, Mark ANDERSON, Richard BRINGHAM, Michael VAN DRIEL, Waleed H. HASSANEIN
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Patent number: 10750738Abstract: Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.Type: GrantFiled: April 8, 2008Date of Patent: August 25, 2020Assignee: TRANSMEDICS, INC.Inventors: Robert Fishman, Robert Havener, Ihab Abdel Fattah, Anas Abdelazim, Scott Newell, Thomas H. Bishop, Tamer Khayal, Stanley Kyi, Ron Taylor, Doug Harriott, Matthew De Remer, Paul Murray, John Sullivan, Mark Anderson, Richard Bringham, Michael Van Driel, Waleed Hassanein
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Publication number: 20190269125Abstract: Electrode systems have been developed for use in perfusion systems to measure the electrical activity of an explanted heart and to provide defibrillation energy as necessary. The perfusion systems maintain the heart in a beating state at, or near, normal physiological conditions; circulating oxygenated, nutrient enriched perfusion fluid to the heart at or near physiological temperature, pressure and flow rate. These systems include a pair of electrodes that are placed epicardially on the right atrium and left ventricle of the explanted heart, as well as an electrode placed in the aortic blood path.Type: ApplicationFiled: May 21, 2019Publication date: September 5, 2019Inventors: Waleed H. HASSANEIN, Ahmed ELBETANONY, Richard BRINGHAM, Robert HAVENER, Vincent LAMBERT, II, Burt OCHS
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Patent number: 10327443Abstract: Electrode systems have been developed for use in perfusion systems to measure the electrical activity of an explanted heart and to provide defibrillation energy as necessary. The perfusion systems maintain the heart in a heating state at, or near, normal physiological conditions; circulating oxygenated, nutrient enriched perfusion fluid to the heart at or near physiological temperature, pressure and flow rate. These systems include a pair of electrodes that are placed epicardially on the right atrium and left ventricle of the explanted heart, as well as an electrode placed in the aortic blood path.Type: GrantFiled: July 11, 2016Date of Patent: June 25, 2019Assignee: TRANSMEDICS, INC.Inventors: Waleed H. Hassanein, Ahmed Elbetanony, Richard Bringham, Robert Havener, Vincent Lambert, II, Burt Ochs
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Patent number: 9814230Abstract: Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.Type: GrantFiled: April 8, 2008Date of Patent: November 14, 2017Assignee: TRANSMEDICS, INC.Inventors: Robert Fishman, Robert Havener, Ihab Abdel Fattah, Anas Abdelazim, Scott Newell, Tom Bishop, Tamer Khayal, Stanley Kyi, Ron Taylor, Doug Harriott, Matthew De Remer, Paul Murray, John Sullivan, Mark Anderson, Richard Bringham, Michael Van Driel, Waleed Hassanein
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Publication number: 20160374332Abstract: Electrode systems have been developed for use in perfusion systems to measure the electrical activity of an explanted heart and to provide defibrillation energy as necessary. The perfusion systems maintain the heart in a heating state at, or near, normal physiological conditions; circulating oxygenated, nutrient enriched perfusion fluid to the heart at or near physiological temperature, pressure and flow rate. These systems include a pair of electrodes that are placed epicardially on the right atrium and left ventricle of the explanted heart, as well as an electrode placed in the aortic blood path.Type: ApplicationFiled: July 11, 2016Publication date: December 29, 2016Applicant: TransMedics, IncInventors: Waleed H. HASSANEIN, Ahmed ELBETANONY, Richard BRINGHAM, Robert HAVENER, Vincent LAMBERT, II, Burt OCHS
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Patent number: 9516875Abstract: Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.Type: GrantFiled: February 12, 2013Date of Patent: December 13, 2016Assignee: TRANSMEDICS, INC.Inventors: Robert Fishman, Robert Havener, Ihab A. Fattah, Anas Abdelazim, Scott Newell, Thomas H. Bishop, Tamer I. Khayal, Stanley Kyi, Ron Taylor, Jr., Doug Harriott, Matthew De Remer, Paul Murray, John Sullivan, Mark Anderson, Richard Bringham, Michael Van Driel, Waleed H. Hassanein
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Patent number: 9462802Abstract: Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.Type: GrantFiled: April 8, 2008Date of Patent: October 11, 2016Assignee: TRANSMEDICS, INC.Inventors: Robert Fishman, Robert Havener, Ihab Abdel Fattah, Anas Abdelazim, Scott Newell, Tom Bishop, Tamer Khayal, Stanley Kyi, Ron Taylor, Doug Harriott, Matthew De Remer, Paul Murray, John Sullivan, Mark Anderson, Richard Bringham, Michael Van Driel, Waleed Hassanein
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Patent number: 9457179Abstract: Electrode systems have been developed for use in perfusion systems to measure the electrical activity of an explanted heart and to provide defibrillation energy as necessary. The perfusion systems maintain the heart in a beating state at, or near, normal physiological conditions; circulating oxygenated, nutrient enriched perfusion fluid to the heart at or near physiological temperature, pressure and flow rate. These systems include a pair of electrodes that are placed epicardially on the right atrium and left ventricle of the explanted heart, as well as an electrode placed in the aortic blood path.Type: GrantFiled: July 6, 2007Date of Patent: October 4, 2016Assignee: TRANSMEDICS, INC.Inventors: Waleed Hassanein, Ahmed Elbetanony, Richard Bringham, Robert Havener, Vincent Lambert, II, Burt Ochs
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Patent number: 9247728Abstract: Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.Type: GrantFiled: April 8, 2008Date of Patent: February 2, 2016Assignee: TRANSMEDICS, INC.Inventors: Robert Fishman, Robert Havener, Ihab Abdel Fattah, Anas Abdelazim, Scott Newell, Tom Bishop, Tamer Khayal, Stanley Kyi, Ron Taylor, Doug Harriott, Matthew De Remer, Paul Murray, John Sullivan, Mark Anderson, Richard Bringham, Michael Van Driel, Waleed Hassanein
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Publication number: 20150079580Abstract: The invention, in various embodiments, provides systems, methods and solutions for perfusing an organ ex vivo.Type: ApplicationFiled: August 20, 2014Publication date: March 19, 2015Applicant: TRANSMEDICS, INCInventors: Waleed H. HASSANEIN, Tamer I. KHAYAL, Robert HAVENER, Stanley KYI, Ihab Abdel FATTAH, Hesham SALEH, Jon C. TRACHTENBERG
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Patent number: 8822203Abstract: The invention, in various embodiments, provides systems, methods and solutions for perfusing an organ ex vivo.Type: GrantFiled: September 28, 2010Date of Patent: September 2, 2014Assignee: TransMedics, Inc.Inventors: Waleed Hassanein, Tamer Khayal, Robert Havener, Stanley Kyi, Ihab Abdel Fattah, Hesham Saleh, Jon C. Trachtenberg
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Patent number: 8535934Abstract: The invention, in various embodiments, provides systems, methods and solutions using an organ ex vivo.Type: GrantFiled: April 19, 2007Date of Patent: September 17, 2013Assignee: TransMedics, Inc.Inventors: Waleed Hassanein, Tamer Khayal, Robert Havener, Stanley Kyi, Ihab Abdel Fattah, Hesham Saleh, Jon Trachtenberg
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Patent number: 8420380Abstract: Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.Type: GrantFiled: April 8, 2008Date of Patent: April 16, 2013Assignee: TransMedics, Inc.Inventors: Robert Fishman, Robert Havener, Ihab Abdel Fattah, Anas Abdelazim, Scott Newell, Tom Bishop, Tamer Khayal, Stanley Kyi, Ron Taylor, Doug Harriott, Matthew De Remer, Paul Murray, John Sullivan, Mark Anderson, Richard Bringham, Michael Van Driel, Waleed Hassanein
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Publication number: 20130011823Abstract: An ex-vivo lung solution for machine perfusion of donor lungs on OCS. The solution may be mixed with whole blood or packed red blood cells to form the OCS lung perfusion solution.Type: ApplicationFiled: April 13, 2012Publication date: January 10, 2013Inventors: Waleed H. Hassanein, Ihab A. FATTAH, Paul LEZBERG, Tamer I. KHAYAL, Robert HAVENER, Anas ABDELAZIM
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Publication number: 20110136096Abstract: The invention, in various embodiments, provides systems, methods and solutions for perfusing an organ ex vivo.Type: ApplicationFiled: September 28, 2010Publication date: June 9, 2011Applicant: TransMedics, Inc.Inventors: Waleed Hassanein, Tamer Khayal, Robert Havener, Stanley Kyi, Ihab Abdel Fattah, Hesham Saleh, Jon C. Trachtenberg