Abstract: Provided herein are recombinant antibodies and antigen-binding fragments thereof useful for binding to and inhibiting carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1). Also provided are methods of using the disclosed CEACAM1 antibodies and antigen-binding fragments thereof for reducing T-cell tolerance and for the treatment of cancer.

Abstract: Provided herein are recombinant antibodies and antigen-binding fragments thereof useful for binding to and inhibiting carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1). Also provided are methods of using the disclosed CEACAM1 antibodies and antigen-binding fragments thereof for reducing T-cell tolerance and for the treatment of cancer.

Abstract: Devices and techniques for out-of-band platform tuning and configuration are described herein. A device can include a telemetry interface to a telemetry collection system and a network interface to network adapter hardware. The device can receive platform telemetry metrics from the telemetry collection system, and network adapter silicon hardware statistics over the network interface, to gather collected statistics. The device can apply a heuristic algorithm using the collected statistics to determine processing core workloads generated by operation of a plurality of software systems communicatively coupled to the device. The device can provide a reconfiguration message to instruct at least one software system to switch operations to a different processing core, responsive to detecting an overload state on at least one processing core, based on the processing core workloads. Other embodiments are also described.

Abstract: Devices and techniques for out-of-band platform tuning and configuration are described herein. A device can include a telemetry interface to a telemetry collection system and a network interface to network adapter hardware. The device can receive platform telemetry metrics from the telemetry collection system, and network adapter silicon hardware statistics over the network interface, to gather collected statistics. The device can apply a heuristic algorithm using the collected statistics to determine processing core workloads generated by operation of a plurality of software systems communicatively coupled to the device. The device can provide a reconfiguration message to instruct at least one software system to switch operations to a different processing core, responsive to detecting an overload state on at least one processing core, based on the processing core workloads. Other embodiments are also described.

Abstract: Provided herein are recombinant antibodies and antigen-binding fragments thereof useful for binding to and inhibiting carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1). Also provided are methods of using the disclosed CEACAM1 antibodies and antigen-binding fragments thereof for reducing T-cell tolerance and for the treatment of cancer.

Abstract: Generally discussed herein are systems, devices, and methods for network security monitoring (NSM). A hardware queue manager (HQM) may include an input interface to receive first data from at least a first worker thread, queue duplication circuitry to generate a copy of at least a portion of the first data to create first copied data, and an output interface to (a) provide the first copied data to a second worker thread, and/or (b) provide at least a portion of the first data to a third worker thread.

Abstract: An antibody or antigen-binding portion thereof which binds to PSMA and comprises a heavy chain variable domain comprising the sequences: CDR1: EYTIH (SEQ ID NO: 33) CDR2: NINPNX1GGTTYNQKFED (SEQ ID NO: 34) CDR3: X2-5DY (SEQ ID NO: 35) wherein X1 is N or Q, and X2-5 is YWLF (SEQ ID NO: 39), GWTF (SEQ ID NO: 40) or AWTM (SEQ ID NO: 41), and wherein if X2-5 is GWTF (SEQ ID NO: 40) or AWTM (SEQ ID NO: 41), the amino acid residue at position H94 in the heavy chain variable region, based on Kabat numbering, is G; and if X2-5 is YWLF (SEQ ID NO: 39), the amino acid residue at position H94 in the heavy chain variable region, based on Kabat numbering, is A. The invention also provides compounds that include the antibody or antigen-binding portion thereof, such as conjugates, and their use in the treatment or diagnosis of disease, in particular cancers, particularly prostate cancer.

Abstract: System and techniques for multifactor intelligent agent control are described herein. A workload request may be received from a user device via a network. The workload may be instantiated in an isolated environment on an edge computing platform. Here, the isolated environment may be a container or a virtual machine. The instantiation of the workload may include using a hardware security component (SEC) of the mobile edge computing platform to prevent access to data or code of the workload from other environments hosted by the mobile edge computing platform. The workload may then be executed in the isolated environment and a result of the workload returned to the user device.

Abstract: In one embodiment, a system comprises platform logic comprising a plurality of processor cores and resource allocation logic. The resource allocation logic may receive a processing request and direct the processing request to a processor core of the plurality of processor cores, wherein the processor core is selected based at least in part on telemetry data associated with the platform logic, the telemetry data indicating a topology of at least a portion of the platform logic.

Abstract: Provided herein are recombinant antibodies and antigen-binding portions thereof useful for binding to FcRn and blocking binding of FcRn to IgG Fc. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.

Abstract: Provided herein are recombinant antibodies and antigen-binding portions thereof useful for binding to FcRn and blocking binding of FcRn to IgG Fc. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.

Abstract: Provided herein are recombinant antibodies and antigen-binding portions thereof useful for binding to FcRn and blocking binding of FcRn to IgG Fc. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.

Abstract: Devices and techniques for out-of-band platform tuning and configuration are described herein. A device can include a telemetry interface to a telemetry collection system and a network interface to network adapter hardware. The device can receive platform telemetry metrics from the telemetry collection system, and network adapter silicon hardware statistics over the network interface, to gather collected statistics. The device can apply a heuristic algorithm using the collected statistics to determine processing core workloads generated by operation of a plurality of software systems communicatively coupled to the device. The device can provide a reconfiguration message to instruct at least one software system to switch operations to a different processing core, responsive to detecting an overload state on at least one processing core, based on the processing core workloads. Other embodiments are also described.

Abstract: An antibody or antigen-binding portion thereof which binds to PSMA and comprises a heavy chain variable domain comprising the sequences: (SEQ ID NO: 33) CDR1: EYTIH (SEQ ID NO: 34) CDR2: NINPNX1GGTTYNQKFED (SEQ ID NO: 35) CDR3: X2-5DY wherein X1 is N or Q, and X2-5 is YWLF, GWTF or AWTM, and wherein if X2-5 is GWTF or AWTM, the amino acid residue at position H94 in the heavy chain variable region, based on Kabat numbering, is G; and if X2-5 is YWLF, the amino acid residue at position H94 in the heavy chain variable region, based on Kabat numbering, is A. The invention also provides compounds that include the antibody or antigen-binding portion thereof, such as conjugates, and their use in the treatment or diagnosis of diseases, in particular cancers, particularly prostate cancer.

Abstract: System and techniques for multifactor intelligent agent control are described herein. A workload request may be received from a user device via a network. The workload may be instantiated in an isolated environment on an edge computing platform. Here, the isolated environment may be a container or a virtual machine. The instantiation of the workload may include using a hardware security component (SEC) of the mobile edge computing platform to prevent access to data or code of the workload from other environments hosted by the mobile edge computing platform. The workload may then be executed in the isolated environment and a result of the workload returned to the user device.

Abstract: Devices and techniques for out-of-band platform tuning and configuration are described herein. A device can include a telemetry interface to a telemetry collection system and a network interface to network adapter hardware. The device can receive platform telemetry metrics from the telemetry collection system, and network adapter silicon hardware statistics over the network interface, to gather collected statistics. The device can apply a heuristic algorithm using the collected statistics to determine processing core workloads generated by operation of a plurality of software systems communicatively coupled to the device. The device can provide a reconfiguration message to instruct at least one software system to switch operations to a different processing core, responsive to detecting an overload state on at least one processing core, based on the processing core workloads. Other embodiments are also described.

Abstract: Generally discussed herein are systems, devices, and methods for network security monitoring (NSM). A hardware queue manager (HQM) may include an input interface to receive first data from at least a first worker thread, queue duplication circuitry to generate a copy of at least a portion of the first data to create first copied data, and an output interface to (a) provide the first copied data to a second worker thread, and/or (b) provide at least a portion of the first data to a third worker thread.

Abstract: Provided herein are recombinant antibodies and antigen-binding portions thereof useful for binding to FcRn and blocking binding of FcRn to IgG Fc. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.

Abstract: Devices and techniques for out-of-band platform tuning and configuration are described herein. A device can include a telemetry interface to a telemetry collection system and a network interface to network adapter hardware. The device can receive platform telemetry metrics from the telemetry collection system, and network adapter silicon hardware statistics over the network interface, to gather collected statistics. The device can apply a heuristic algorithm using the collected statistics to determine processing core workloads generated by operation of a plurality of software systems communicatively coupled to the device. The device can provide a reconfiguration message to instruct at least one software system to switch operations to a different processing core, responsive to detecting an overload state on at least one processing core, based on the processing core workloads. Other embodiments are also described.

Abstract: In one embodiment, a system comprises platform logic comprising a plurality of processor cores and resource allocation logic. The resource allocation logic may receive a processing request and direct the processing request to a processor core of the plurality of processor cores, wherein the processor core is selected based at least in part on telemetry data associated with the platform logic, the telemetry data indicating a topology of at least a portion of the platform logic.