Abstract: The present disclosure provides methods that find use in determining a likelihood of adverse prostate cancer pathology in a subject. The methods generally involve detection of one or more diagnostic microRNAs (miRNAs), such as mir-19a, mir-19b, mir-519c-5p, and/or mir-345 in a biological sample from the subject, such as blood or blood product. The detection of one or more such diagnostic miRNAs can be used to determine a likelihood of adverse prostate cancer pathology in a subject. The methods of the present disclosure also find use in facilitating treatment decisions for a subject. Also provided are devices, systems, and kits that may be used in practicing methods of the present disclosure.

Abstract: The present disclosure provides methods that find use in determining a likelihood of adverse prostate cancer pathology in a subject. The methods generally involve detection of one or more diagnostic microRNAs (miRNAs), such as mir-19a, mir-19b, mir-519c-5p, and/or mir-345 in a biological sample from the subject, such as blood or blood product. The detection of one or more such diagnostic miRNAs can be used to determine a likelihood of adverse prostate cancer pathology in a subject. The methods of the present disclosure also find use in facilitating treatment decisions for a subject. Also provided are devices, systems, and kits that may be used in practicing methods of the present disclosure.

Abstract: Methods and apparatus, including computer program products, for managing pre-trade activity. In general, a distribution of information about what traders and customers want to do may be known. Users may be made aware of trade ideas that can be proposed to a trading desk's buy-side clients. Relevant information on the trading desk may be brought together, and the information may be processed through a set of rules that extract trading opportunities. On the buy side, trade ideas may be extracted without having to have the intervention of a sell-side salesforce.

Abstract: Methods and apparatus, including computer program products, for managing pre-trade activity. In general, a distribution of information about what traders and customers want to do may be known. Users may be made aware of trade ideas that can be proposed to a trading desk's buy-side clients. Relevant information on the trading desk may be brought together, and the information may be processed through a set of rules that extract trading opportunities. On the buy side, trade ideas may be extracted without having to have the intervention of a sell-side salesforce.