Patents by Inventor Robert Heft

Robert Heft has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BONE TARGETED ALKALINE PHOSPHATASE, KITS AND METHODS OF USE THEREOF
    Publication number: 20100297119
    Abstract: A bone targeted alkaline phosphatase comprising a polypeptide having the structure: Z-sALP-Y-spacer-X-Wn-V, wherein sALP is the extracellular domain of the alkaline phosphatase; wherein V is absent or is an amino acid sequence of at least one amino acid; X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; and Wn is a polyaspartate or a polyglutamate wherein n=10 to 16. Kits and methods of use thereof.
    Type: Application
    Filed: May 12, 2008
    Publication date: November 25, 2010
    Inventors: Philippe Crine, Guy Boileau, Thomas P. Loisel, Isabelle Lemire, Pierre Léonard, Robert Heft, Hal Landy
  • Variants and chemically-modified variants of phenylalanine ammonia-lyase
    Patent number: 7553653
    Abstract: The present invention pertains to the use of the protein phenylalanine ammonia-lyase, as well as the biologically-active derivatives of the said protein for preventing or treating diseases associated with a phenylalanine imbalance in a human or animal body. More particularly, the present invention relates to the therapeutic use of the above-cited molecules for preventing or treating a phenylalanine imbalance in vivo. This invention also deals with therapeutic compositions comprising a pharmaceutically active amount of the above-described therapeutic molecules as well as with therapeutic methods using the said therapeutic compositions. Finally, the present invention relates to processes for selecting more therapeutically-effective variants of said protein as well as to the selected variants themselves.
    Type: Grant
    Filed: September 19, 2005
    Date of Patent: June 30, 2009
    Assignees: BioMarin Pharmaceutical Inc., The Scripps Research Institute
    Inventors: Emilio Kakkis, Daniel Oppenheimer, Paul Fitzpatrick, Robert Heft, Alejandra Gamez, Lin Wang, Woomi Kim, Mary Straub, Marianne Patch, Raymond C. Stevens
  • Variants and chemically-modified variants of phenylalanine ammonia-lyase
    Publication number: 20070048855
    Abstract: The present invention pertains to the use of the protein phenylalanine ammonia-lyase, as well as the biologically-active derivatives of the said protein for preventing or treating diseases associated with a phenylalanine imbalance in a human or animal body. More particularly, the present invention relates to the therapeutic use of the above-cited molecules for preventing or treating a phenylalanine imbalance in vivo. This invention also deals with therapeutic compositions comprising a pharmaceutically active amount of the above-described therapeutic molecules as well as with therapeutic methods using the said therapeutic compositions. Finally, the present invention relates to processes for selecting more therapeutically-effective variants of said protein as well as to the selected variants themselves.
    Type: Application
    Filed: September 19, 2005
    Publication date: March 1, 2007
    Inventors: Alejandra Gamez, Lin Wang, Woomi Kim, Mary Straub, Marianne Patch, Emil Kakkis, Dan Oppenheimer, Paul Fitzpatrick, Robert Heft, Raymond Stevens