Patents by Inventor Robert Heger
Robert Heger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240382779Abstract: A method for treating a tumor, comprising identifying a tumor as a colorectal cancer tumor and implanting in the tumor identified as a colorectal cancer tumor, as least one diffusing alpha-emitter radiation therapy (DaRT) source with a suitable radon release rate and for a given duration, such that the source provides during the given duration a cumulated activity of released radon between 3.7 Mega becquerel (MBq) hour and 9.2 MBq hour, per centimeter length.Type: ApplicationFiled: July 25, 2024Publication date: November 21, 2024Inventors: Itzhak Kelson, Yona Keisari, Amnon Gat, Robert Den, Ofer Magen, Vered Domankevich, Lior Arazi, Tomer Cooks, Guy Heger, Mirta Dumancic, Ishai Luz, Maayan Hedva Vatarescu
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Publication number: 20240382780Abstract: A method for treating a tumor, comprising identifying a tumor as a melanoma tumor and implanting in the tumor identified as a melanoma tumor, as least one diffusing alpha-emitter radiation therapy (DaRT) source with a suitable radon release rate and for a given duration, such that the source provides during the given duration a cumulated activity of released radon between 3.2 Mega becquerel (MBq) hour and 7.5 MBq hour, per centimeter length.Type: ApplicationFiled: July 25, 2024Publication date: November 21, 2024Inventors: Itzhak Kelson, Yona Keisari, Amnon Gat, Robert Den, Ofer Magen, Vered Domankevich, Lior Arazi, Tomer Cooks, Guy Heger, Mirta Dumancic, Ishai Luz, Maayan Hedva Vatarescu
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Publication number: 20240374921Abstract: A method for treating a tumor, comprising identifying a tumor as a glioblastoma tumor and implanting in the tumor identified as a glioblastoma tumor, as least one diffusing alpha-emitter radiation therapy (DaRT) source with a suitable radon release rate and for a given duration, such that the source provides during the given duration a cumulated activity of released radon between 6.5 Mega becquerel (MBq) hour and 14.3 MBq hour, per centimeter length.Type: ApplicationFiled: July 25, 2024Publication date: November 14, 2024Inventors: Itzhak Kelson, Yona Keisari, Amnon Gat, Robert Den, Ofer Magen, Vered Domankevich, Lior Arazi, Tomer Cooks, Guy Heger, Mirta Dumancic, Ishai Luz, Maayan Hedva Vatarescu
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Publication number: 20240374920Abstract: A method for treating a tumor, comprising identifying a tumor as a pancreatic cancer tumor and implanting in the tumor identified as a pancreatic cancer tumor, as least one diffusing alpha-emitter radiation therapy (DaRT) source (21) with a suitable radon release rate and for a given duration, such that the source (21) provides during the given duration a cumulated activity of released radon between 5.6 Mega becquerel (MBq) hour and 11.6 MBq hour, per centimeter length.Type: ApplicationFiled: July 25, 2024Publication date: November 14, 2024Inventors: Itzhak Kelson, Yona Keisari, Amnon Gat, Robert Den, Ofer Magen, Vered Domankevich, Lior Arazi, Tomer Cooks, Guy Heger, Mirta Dumancic, Ishai Luz, Maayan Hedva Vatarescu
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Publication number: 20240374919Abstract: A method for treating a cancerous tumor, by implanting in the cancerous tumor at least one diffusing alpha-emitter radiation therapy (DaRT) source with a suitable radon release rate and for a given duration, such that the source provides during the given duration a cumulated activity of released radon of at least 10 Mega becquerel (MBq) hour, per centimeter length. Optionally, the sources are implanted in an array of sources, each source separated from its neighboring sources in the array by not more than 4.5 millimeters.Type: ApplicationFiled: July 23, 2024Publication date: November 14, 2024Inventors: Itzhak Kelson, Yona Keisari, Amnon Gat, Robert Den, Ofer Magen, Vered Domankevich, Lior Arazi, Tomer Cooks, Guy Heger, Mirta Dumancic, Ishai Luz, Maayan Hedva Vatarescu
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Publication number: 20240374922Abstract: A method for treating a tumor, comprising identifying a tumor as a breast cancer tumor and implanting in the tumor identified as a breast cancer tumor, as least one diffusing alpha-emitter radiation therapy (DaRT) source with a suitable radon release rate and for a given duration, such that the source provides during the given duration a cumulated activity of released radon between 3.5 Mega becquerel (MBq) hour and 9 MBq hour, per centimeter length.Type: ApplicationFiled: July 25, 2024Publication date: November 14, 2024Inventors: Itzhak Kelson, Yona Keisari, Amnon Gat, Robert Den, Ofer Magen, Vered Domankevich, Lior Arazi, Tomer Cooks, Guy Heger, Mirta Dumancic, Ishai Luz, Maayan Hedva Vatarescu
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Patent number: 12076582Abstract: A method for treating a tumor, comprising identifying a tumor as a colorectal cancer tumor and implanting in the tumor identified as a colorectal cancer tumor, at least one diffusing alpha-emitter radiation therapy (DaRT) source (21) with a suitable radon release rate and for a given duration, such that the source (21) provides during the given duration a cumulated activity of released radon between 3.7 Mega becquerel (MBq) hour and 9.2 MBq hour, per centimeter length.Type: GrantFiled: January 9, 2023Date of Patent: September 3, 2024Assignee: ALPHA TAU MEDICAL LTD.Inventors: Itzhak Kelson, Yona Keisari, Amnon Gat, Robert Den, Ofer Magen, Vered Domankevich, Lior Arazi, Tomer Cooks, Guy Heger, Mirta Duman{hacek over (c)}ić, Ishai Luz, Maayan Hedva Vatarescu
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Patent number: 12076583Abstract: A method for treating a tumor, comprising identifying a tumor as a melanoma tumor and implanting in the tumor identified as a melanoma tumor, at least one diffusing alpha-emitter radiation therapy (DaRT) source (21) with a suitable radon release rate and for a given duration, such that the source (21) provides during the given duration a cumulated activity of released radon between 3.2 Mega becquerel (MBq) hour and 7.5 MBq hour, per centimeter length.Type: GrantFiled: January 9, 2023Date of Patent: September 3, 2024Assignee: ALPHA TAU MEDICAL LTD.Inventors: Itzhak Kelson, Yona Keisari, Amnon Gat, Robert Den, Ofer Magen, Vered Domankevich, Lior Arazi, Tomer Cooks, Guy Heger, Mirta Duman{hacek over (c)}ić, Ishai Luz, Maayan Hedva Vatarescu
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Patent number: 12076581Abstract: A method for treating a tumor, comprising identifying a tumor as a glioblastoma tumor and implanting in the tumor identified as a glioblastoma tumor, at least one diffusing alpha-emitter radiation therapy (DaRT) source (21) with a suitable radon release rate and for a given duration, such that the source (21) provides during the given duration a cumulated activity of released radon between 6.5 Mega becquerel (MBq) hour and 14.3 MBq hour, per centimeter length.Type: GrantFiled: January 9, 2023Date of Patent: September 3, 2024Assignee: ALPHA TAU MEDICAL LTD.Inventors: Itzhak Kelson, Yona Keisari, Amnon Gat, Robert Den, Ofer Magen, Vered Domankevich, Lior Arazi, Tomer Cooks, Guy Heger, Mirta Duman{hacek over (c)}ić, Ishai Luz, Maayan Hedva Vatarescu
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Patent number: 12070621Abstract: A method for treating a tumor, comprising identifying a tumor as a pancreatic cancer tumor and implanting in the tumor identified as a pancreatic cancer tumor, at least one diffusing alpha-emitter radiation therapy (DaRT) source (21) with a suitable radon release rate and for a given duration, such that the source (21) provides during the given duration a cumulated activity of released radon between 5.6 Mega becquerel (MBq) hour and 11.6 MBq hour, per centimeter length.Type: GrantFiled: January 9, 2023Date of Patent: August 27, 2024Assignee: ALPHA TAU MEDICAL LTD.Inventors: Itzhak Kelson, Yona Keisari, Amnon Gat, Robert Den, Ofer Magen, Vered Domankevich, Lior Arazi, Tomer Cooks, Guy Heger, Mirta Duman{hacek over (c)}ić, Ishai Luz, Maayan Hedva Vatarescu
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Patent number: 12070620Abstract: A method for treating a cancerous tumor, by implanting in the cancerous tumor at least one diffusing alpha-emitter radiation therapy (DaRT) source (21) with a suitable radon release rate and for a given duration, such that the source (21) provides during the given duration a cumulated activity of released radon of at least 10 Mega becquerel (MBq) hour, per centimeter length. Optionally, the sources (21) are implanted in an array (160) of sources (21), each source separated from its neighboring sources (21) in the array by not more than 4.5 millimeters.Type: GrantFiled: January 9, 2023Date of Patent: August 27, 2024Assignee: ALPHA TAU MEDICAL LTD.Inventors: Itzhak Kelson, Yona Keisari, Amnon Gat, Robert Den, Ofer Magen, Vered Domankevich, Lior Arazi, Tomer Cooks, Guy Heger, Mirta Duman{hacek over (c)}ić, Ishai Luz, Maayan Hedva Vatarescu
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Patent number: 12064643Abstract: A method for treating a tumor, comprising identifying a tumor as a breast cancer tumor and implanting in the tumor identified as a breast cancer tumor, at least one diffusing alpha-emitter radiation therapy (DaRT) source (21) with a suitable radon release rate and for a given duration, such that the source (21) provides during the given duration a cumulated activity of released radon between 3.5 Mega becquerel (MBq) hour and 9 MBq hour, per centimeter length.Type: GrantFiled: January 9, 2023Date of Patent: August 20, 2024Assignee: ALPHA TAU MEDICAL LTD.Inventors: Itzhak Kelson, Yona Keisari, Amnon Gat, Robert Den, Ofer Magen, Vered Domankevich, Lior Arazi, Tomer Cooks, Guy Heger, Mirta Duman{hacek over (c)}ić, Ishai Luz, Maayan Hedva Vatarescu
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Patent number: 12042668Abstract: A method for treating a tumor, comprising identifying a tumor as a squamous cell carcinoma tumor and implanting in the tumor identified as a squamous cell carcinoma tumor at least one diffusing alpha-emitter radiation therapy (DaRT) source (21) with a suitable radon release rate and for a given duration, such that the source (21) provides during the given duration a cumulated activity of released radon between 3.7 Mega becquerel (MBq) hour and 8.6 MBq hour, per centimeter length.Type: GrantFiled: January 9, 2023Date of Patent: July 23, 2024Assignee: ALPHA TAU MEDICAL LTD.Inventors: Itzhak Kelson, Yona Keisari, Amnon Gat, Robert Den, Ofer Magen, Vered Domankevich, Lior Arazi, Tomer Cooks, Guy Heger, Mirta Duman{hacek over (c)}ić, Ishai Luz, Maayan Hedva Vatarescu
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Publication number: 20140135388Abstract: The present invention relates to self-emulsifying formulations based on an active ingredient component and a formulation base with a lipid component and with a binder component and to the use of this formulation as dosage form in the life science sector. The invention also describes a process for producing self-emulsifying formulations by mixing the formulation components to form a plastic mixture and, where appropriate, to manufacture the formulations as dosage form advantageously by use of melt extrusion. The formulations spontaneously form emulsions in water or aqueous media.Type: ApplicationFiled: June 6, 2013Publication date: May 15, 2014Inventors: Gunther BERNDL, Joerg BREITENBACH, Robert HEGER, Joerg ROSENBERG, Michael STADLER, Peter WILKE
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Patent number: 8470347Abstract: The present invention relates to self-emulsifying formulations based on an active ingredient component and a formulation base with a lipid component and with a binder component and to the use of this formulation as dosage form in the life science sector. The invention also describes a process for producing self-emulsifying formulations by mixing the formulation components to form a plastic mixture and, where appropriate, to manufacture the formulations as dosage form advantageously by use of melt extrusion. The formulations spontaneously form emulsions in water or aqueous media.Type: GrantFiled: May 29, 2001Date of Patent: June 25, 2013Assignee: AbbVie Deutschland GmbH and Co KGInventors: Gunther Berndl, Jörg Breitenbach, Robert Heger, Michael Stadler, Peter Wilke, Jörg Rosenberg
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Publication number: 20120225953Abstract: The present invention relates to self-emulsifying formulations based on an active ingredient component and a formulation base with a lipid component and with a binder component and to the use of this formulation as dosage form in the life science sector. The invention also describes a process for producing self-emulsifying formulations by mixing the formulation components to form a plastic mixture and, where appropriate, to manufacture the formulations as dosage form advantageously by use of melt extrusion. The formulations spontaneously form emulsions in water or aqueous media.Type: ApplicationFiled: April 18, 2012Publication date: September 6, 2012Applicant: ABBOTT GMBH & CO. KGInventors: Gunther Berndl, Jörg Breitenbach, Robert Heger, Michael Stadler, Peter Wilke, Jörg Rosenberg
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Patent number: 8197829Abstract: The present invention relates to self-emulsifying formulations based on an active ingredient component and a formulation base with a lipid component and with a binder component and to the use of this formulation as dosage form in the life science sector. The invention also describes a process for producing self-emulsifying formulations by mixing the formulation components to form a plastic mixture and, where appropriate, to manufacture the formulations as dosage form advantageously by use of melt extrusion. The formulations spontaneously form emulsions in water or aqueous media.Type: GrantFiled: May 29, 2001Date of Patent: June 12, 2012Assignee: Abbott LaboratoriesInventors: Gunther Berndl, Jörg Breitenbach, Robert Heger, Michael Stadler, Peter Wilke, Jörg Rosenberg
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Publication number: 20110123652Abstract: The present invention relates to self-emulsifying formulations based on an active ingredient component and a formulation base with a lipid component and with a binder component and to the use of this formulation as dosage form in the life science sector. The invention also describes a process for producing self-emulsifying formulations by mixing the formulation components to form a plastic mixture and, where appropriate, to manufacture the formulations as dosage form advantageously by use of melt extrusion. The formulations spontaneously form emulsions in water or aqueous media.Type: ApplicationFiled: October 6, 2010Publication date: May 26, 2011Inventors: Gunther Berndl, Jörg Breitenbach, Jörg Rosenberg, Robert Heger, Michael Stadler, Peter Wilke
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Publication number: 20100189994Abstract: Aqueous dispersions of crosslinked emulsion polymers comprising tertiary ester groups, comprising (a) at least 50% by weight of an ester derived from a tertiary alcohol and an ethylenically unsaturated C3 to C5 carboxylic acid, (b) 0.001% to 5.0% by weight of at least one compound having at least two ethylenically unsaturated double bonds, and (c) 0% to 49.999% by weight of at least one other monoethylenically unsaturated compound in interpolymerized form and having an average particle size of not more than 1000 nm, and water-absorbing materials obtainable by coating a backing material with the aqueous dispersion described of crosslinked emulsion polymers comprising tertiary ester groups, drying and heating the thus treated backing material to a temperature of at least 140° C. to form carboxyl groups from the tertiary ester groups of the emulsion polymer and at least partly neutralizing the carboxyl groups, and also the use of the water-absorbing materials as an absorbent for water and aqueous fluids.Type: ApplicationFiled: August 6, 2007Publication date: July 29, 2010Applicant: BASF SEInventors: Marc Bothe, Hermann Seyffer, Mirjam Herrlich-Loos, Robert Heger, Matthias Weismantel
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Patent number: 7687071Abstract: Nanoparticulate preparations of pharmaceutical and cosmetic active substances with a core-shell structure, whereby the active substance is present in an X-ray amorphous form, together with a polymer matrix and the shell consists of a stabilizing sheathing matrix.Type: GrantFiled: December 7, 1999Date of Patent: March 30, 2010Assignee: BASF AktiengesellschaftInventors: Robert Heger, Helmut Auweter, Jörg Breitenbach, Heribert Bohn