Patents by Inventor Robert Heinz
Robert Heinz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11322228Abstract: A method of designing a D-polypeptide that binds with an L-target protein can include: identifying a polypeptide target having L-chirality; determining hotspot amino acids of a polypeptide ligand having L-chirality that have binding interactions with the L-target protein; determining transformations of side chains of the hotspot amino acids that retain the binding interactions with the target; generating inversed hotspot amino acids with chirality opposite to the one of the target; identifying a polypeptide having inverse chirality from the target protein, on which a combination of inversed hotspot amino-acid can be grafted without significantly changing their interactions with the target. The designed ligands can be processed and converted to D-ligands that bind with the L-target protein.Type: GrantFiled: October 27, 2016Date of Patent: May 3, 2022Assignee: Janssen Vaccines & Prevention B.V.Inventors: Jaroslaw Juraszek, Davide Branduardi, Ronald Vogels, Robert Heinz Edward Friesen
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Publication number: 20220096002Abstract: Aspects of the present disclosure provide methods and apparatuses for estimating a biometric parameter using multiple sensors. As described herein, multiple sensors are strategically used to output with increased confidence a biometric parameter. Multiple sensors are strategically used to save power while determining an accurate biometric estimation. Additionally, multiple sensors are used to detect and categorize a sleep apnea event.Type: ApplicationFiled: January 6, 2020Publication date: March 31, 2022Inventors: Tegan M. AYERS, Christopher R. PAETSCH, Dale MCELHONE, Andrew Jackson STOCKTON, David Rolland CRIST, Harsh A. MANKODI, Victoria A. GRACE, Michelle DANIELS, Colin RODDY, Andrew POYNOT, Katie Janine MOENKHAUS, Robert Heinz HASLINGER
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Publication number: 20210393168Abstract: Techniques for user authentication via in-ear acoustic measurements are disclosed. An in-ear device emits an acoustic signal and detects an otic response to the acoustic signal. A user signature is generated based at least on the otic response to the acoustic signal. The user signature is compared with a reference signature, to determine whether the in-ear device has changed users.Type: ApplicationFiled: June 22, 2021Publication date: December 23, 2021Inventors: Keith Robert Santarelli, Andrew Todd Sabin, Brian J. Maguire, John Allen Rule, Robert Heinz Haslinger, Andrew D. Dominijanni
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Patent number: 11136379Abstract: Multimeric binding molecules that are capable of specifically binding to hemagglutinin (HA) of at least two influenza A virus strains, said strains comprising HA of two different HA subtypes from phylogenetic group 2; or capable of specifically binding to hemagglutinin (HA) of at least one influenza A virus strain from phylogenetic group 1 and at least one influenza A virus strain from phylogenetic group 2; or capable of specifically binding to hemagglutinin (HA) of at least one influenza B virus strain are provided. The binding molecules preferably are also capable of neutralizing at least two influenza A virus strains from phylogenetic group 2; or capable of neutralizing at least one influenza A virus strain from phylogenetic group 1 and at least one influenza A virus strain from phylogenetic group 2; or capable of specifically neutralizing at least one influenza B virus strain.Type: GrantFiled: June 5, 2020Date of Patent: October 5, 2021Inventors: Boerries Brandenburg, Ronald Vogels, Joost A. Kolkman, Robert Heinz Edward Friesen
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Publication number: 20200299364Abstract: Multimeric binding molecules that are capable of specifically binding to hemagglutinin (HA) of at least two influenza A virus strains, said strains comprising HA of two different HA subtypes from phylogenetic group 2; or capable of specifically binding to hemagglutinin (HA) of at least one influenza A virus strain from phylogenetic group 1 and at least one influenza A virus strain from phylogenetic group 2; or capable of specifically binding to hemagglutinin (HA) of at least one influenza B virus strain are provided. The binding molecules preferably are also capable of neutralizing at least two influenza A virus strains from phylogenetic group 2; or capable of neutralizing at least one influenza A virus strain from phylogenetic group 1 and at least one influenza A virus strain from phylogenetic group 2; or capable of specifically neutralizing at least one influenza B virus strain.Type: ApplicationFiled: June 5, 2020Publication date: September 24, 2020Inventors: Boerries BRANDENBURG, Ronald Vogels, Joost A. Kolkman, Robert Heinz Edward Friesen
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Patent number: 10703804Abstract: Multimeric binding molecules that are capable of specifically binding to hemagglutinin (HA) of at least two influenza A virus strains, said strains comprising HA of two different HA subtypes from phylogenetic group 2; or capable of specifically binding to hemagglutinin (HA) of at least one influenza A virus strain from phylogenetic group 1 and at least one influenza A virus strain from phylogenetic group 2; or capable of specifically binding to hemagglutinin (HA) of at least one influenza B virus strain are provided. The binding molecules preferably are also capable of neutralizing at least two influenza A virus strains from phylogenetic group 2; or capable of neutralizing at least one influenza A virus strain from phylogenetic group 1 and at least one influenza A virus strain from phylogenetic group 2; or capable of specifically neutralizing at least one influenza B virus strain.Type: GrantFiled: June 27, 2019Date of Patent: July 7, 2020Assignee: Janssen Vaccines & Prevention B.V.Inventors: Boerries Brandenburg, Ronald Vogels, Joost A. Kolkman, Robert Heinz Edward Friesen
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Publication number: 20200143911Abstract: A method of designing a D-polypeptide that binds with an L-target protein can include: identifying a polypeptide target having L-chirality; determining hotspot amino acids of a polypeptide ligand having L-chirality that have binding interactions with the L-target protein; determining transformations of side chains of the hotspot amino acids that retain the binding interactions with the target; generating inversed hotspot amino acids with chirality opposite to the one of the target; identifying a polypeptide having inverse chirality from the target protein, on which a combination of inversed hotspot amino-acid can be grafted without significantly changing their interactions with the target. The designed ligands can be processed and converted to D-ligands that bind with the L-target protein.Type: ApplicationFiled: October 27, 2016Publication date: May 7, 2020Inventors: Jaroslaw JURASZEK, Davide BRANDUARDI, Ronald VOGELS, Robert Heinz Edward FRIESEN
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Publication number: 20190359693Abstract: Multimeric binding molecules that are capable of specifically binding to hemagglutinin (HA) of at least two influenza A virus strains, said strains comprising HA of two different HA subtypes from phylogenetic group 2; or capable of specifically binding to hemagglutinin (HA) of at least one influenza A virus strain from phylogenetic group 1 and at least one influenza A virus strain from phylogenetic group 2; or capable of specifically binding to hemagglutinin (HA) of at least one influenza B virus strain are provided. The binding molecules preferably are also capable of neutralizing at least two influenza A virus strains from phylogenetic group 2; or capable of neutralizing at least one influenza A virus strain from phylogenetic group 1 and at least one influenza A virus strain from phylogenetic group 2; or capable of specifically neutralizing at least one influenza B virus strain.Type: ApplicationFiled: June 27, 2019Publication date: November 28, 2019Inventors: Boerries Brandenburg, Ronald Vogels, Joost A. Kolkman, Robert Heinz Edward Friesen
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Patent number: 10370435Abstract: Monomeric and multimeric binding molecules that are capable of specifically binding to hemagglutinin (HA) of at least two influenza A virus strains, said strains including HA of two different HA subtypes from phylogenetic group 2; or capable of specifically binding to hemagglutinin (HA) of at least one influenza A virus strain from phylogenetic group 1 and at least one influenza A virus strain from phylogenetic group 2; or capable of specifically binding to hemagglutinin (HA) of at least one influenza B virus strain are provided. The binding molecules preferably are also capable of neutralizing at least two influenza A virus strains from phylogenetic group 2; or capable of neutralizing at least one influenza A virus strain from phylogenetic group 1 and at least one influenza A virus strain from phylogenetic group 2; or capable of specifically neutralizing at least one influenza B virus strain.Type: GrantFiled: February 5, 2016Date of Patent: August 6, 2019Assignee: Janssen Vaccines & Prevention B.V.Inventors: Boerries Brandenburg, Ronald Vogels, Joost A. Kolkman, Robert Heinz Edward Friesen
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Publication number: 20190155392Abstract: A user interaction system (1) is provided that comprises an electrical apparatus (10), a beacon (16) that radiates a photon radiation (R16), a portable pointing device (12) operable by a user for pointing to a region in space (20), which portable pointing device includes a camera (122) connected thereto for obtaining images from said space and a digital signal processor (14). The digital signal processor (14) is capable of receiving and processing the images, and of transmitting user interface information, derived by processing the images, to the electrical apparatus.Type: ApplicationFiled: September 30, 2015Publication date: May 23, 2019Inventors: Hendricus Theodorus Gerardus Maria PENNING DE VRIES, Robert Heinz KOLL, Johannes Yzebrand TICHELAAR
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Patent number: 9969849Abstract: The present invention relates to a process for drying particulate polymers, comprising the steps of: a) providing a particulate polymer comprising from 60 wt % to 90 wt % of at least one solvent based on the total weight of particulate polymer and solvent, b) mechanically predrying the particulate polymer to a content of the at least one solvent of from 20 wt % to 50 wt % based on the total weight of particulate polymer and solvent, wherein the mechanical predrying in step b) is carried out with a roller press, and c) end-drying the particulate polymer to a content of the at least one solvent of from 0 wt % to 15 wt % based on the total weight of particulate polymer and solvent, wherein the particulate polymer is a polymer comprising repeating units of formulae I, II and/or III The present invention further relates to a process for working up particulate polymers.Type: GrantFiled: February 16, 2015Date of Patent: May 15, 2018Assignee: BASF SEInventors: Joerg Erbes, Gerhard Lange, Tobias Kortekamp, Bernhard Linner, Cecile Schneider, Angela Ulzhoefer, Robert Heinz, Michael Klemens Mueller
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Publication number: 20180016323Abstract: Monomeric and multimeric binding molecules that are capable of specifically binding to hemagglutinin (HA) of at least two influenza A virus strains, said strains including HA of two different HA subtypes from phylogenetic group 2; or capable of specifically binding to hemagglutinin (HA) of at least one influenza A virus strain from phylogenetic group 1 and at least one influenza A virus strain from phylogenetic group 2; or capable of specifically binding to hemagglutinin (HA) of at least one influenza B virus strain are provided. The binding molecules preferably are also capable of neutralizing at least two influenza A virus strains from phylogenetic group 2; or capable of neutralizing at least one influenza A virus strain from phylogenetic group 1 and at least one influenza A virus strain from phylogenetic group 2; or capable of specifically neutralizing at least one influenza B virus strain.Type: ApplicationFiled: February 5, 2016Publication date: January 18, 2018Inventors: Boerries BRANDENBURG, Ronald VOGELS, Joost A. KOLKMAN, Robert Heinz Edward FRIESEN
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Patent number: 8993802Abstract: The invention relates to a method for producing and using a solid sodium diformate having a high formic acid content, to the use thereof in animal foods in the form of an acidifier, preservatives, ensilage auxiliary agents, fertilizers, and a growth and productivity-stimulating agent and the inventive animal food additives containing sodium diformate.Type: GrantFiled: June 20, 2013Date of Patent: March 31, 2015Assignee: BASF SEInventors: Robert Heinz, Otto Machhammer, Stefan Gropp, Alexander Hauk, Gerd Diebold, Anna Valeska Lohmann, Dieter Feuerstein, Robert Rühle, Rüdiger Schmitt
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Patent number: 8961978Abstract: The present disclosure relates to binding molecules, such as human monoclonal antibodies, that bind to an epitope in the stem region of hemagglutinin of influenza A viruses of phylogenetic group 1 and group 2, as well as influenza B viruses, and have a broad neutralizing activity against such influenza viruses. The disclosure provides nucleic acid molecules encoding the binding molecules, their sequences and compositions comprising the binding molecules. The binding molecules can be used in the diagnosis, prophylaxis and/or treatment of influenza A viruses of phylogenetic groups 1 and 2, as well as influenza B viruses.Type: GrantFiled: July 12, 2012Date of Patent: February 24, 2015Assignee: Crucell Holland B.V.Inventors: Theodorus Hendrikus Jacobus Kwaks, David Adrianus Theodorus Maria Zuijdgeest, Ronald Vogels, Robert Heinz Edward Friesen
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Patent number: 8748366Abstract: A process for the preparation of a spray-dried powder containing at least one glycine-N,N-diacetic acid compound of a formula MOOC—CHR—N(CH2COOM)2, where R is a C1-12-alkyl and M is an alkali metal, the process including: preparing an aqueous solution containing the glycine-N,N-diacetic acid compound; concurrently passing the aqueous solution and air into a spray-drying apparatus; atomizing the aqueous solution by feeding the aqueous solution onto a rotating disk or by compressing the aqueous solution with a pump to a pressure of ?20 bar absolute, to obtain fine liquid droplets; and drying the droplets, to obtain the spray-dried powder, where a temperature gradient between the aqueous solution and the air is in a range from 70 to 350° C., and a content of the glycine-N,N-diacetic acid compound in the aqueous solution is ?84% by weight, based on a total weight of the dry mass.Type: GrantFiled: May 19, 2010Date of Patent: June 10, 2014Assignee: BASF SEInventors: Frank Mrzena, Michael Schoenherr, Robert Heinz, Thomas Heidenfelder
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Publication number: 20140120113Abstract: The present disclosure relates to binding molecules, such as human monoclonal antibodies, that bind to an epitope in the stem region of hemagglutinin of influenza A viruses of phylogenetic group 1 and group 2, as well as influenza B viruses, and have a broad neutralizing activity against such influenza viruses. The disclosure provides nucleic acid molecules encoding the binding molecules, their sequences and compositions comprising the binding molecules. The binding molecules can be used in the diagnosis, prophylaxis and/or treatment of influenza A viruses of phylogenetic groups 1 and 2, as well as influenza B viruses.Type: ApplicationFiled: July 12, 2012Publication date: May 1, 2014Applicant: Crucell Holland B.V.Inventors: Theodorus Hendrikus Jacobus Kwaks, David Adrianus Theodorus Maria Zuijdgeest, Ronald Vogels, Robert Heinz Edward Friesen
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Publication number: 20130281738Abstract: The invention relates to a method for producing and using a solid sodium diformate having a high formic acid content, to the use thereof in animal foods in the form of an acidifier, preservatives, ensilage auxiliary agents, fertilizers, and a growth and productivity-stimulating agent and the inventive animal food additives containing sodium diformate.Type: ApplicationFiled: June 20, 2013Publication date: October 24, 2013Inventors: Robert Heinz, Otto Machhammer, Stefan Gropp, Alexander Hauk, Gerd Diebold, Anna Valeska, Dieter Feuerstein, Robert Rühle, Rüdiger Schmitt
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Patent number: 8497394Abstract: The invention relates to a method for producing and using a solid sodium diformate having a high formic acid content, to the use thereof in animal foods in the form of an acidifier, preservatives, ensilage auxiliary agents, fertilizers, and a growth and productivity-stimulating agent and the inventive animal food additives containing sodium diformate.Type: GrantFiled: August 3, 2012Date of Patent: July 30, 2013Assignee: BASF SEInventors: Robert Heinz, Otto Machhammer, Stefan Gropp, Alexander Hauk, Gerd Diebold, Anna Valeska Lohmann, Dieter Feuerstein, Robert Rühle, Rüdiger Schmitt
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Patent number: 8470327Abstract: Binding molecules, such as human monoclonal antibodies, that bind to influenza virus comprising HA of the H3 subtype, such as H3N2, and have a broad neutralizing activity against such influenza virus. Provided are nucleic acid molecules encoding the antibodies, their sequences and compositions comprising the antibodies and methods of identifying or producing the antibodies. The antibodies can be used in the diagnosis, prophylaxis and/or treatment of an influenza virus H3N2 infection. The antibodies may provide cross-subtype protection, such that infections with H3, H7, and/or H10-based influenza subtypes can be prevented and/or treated.Type: GrantFiled: May 6, 2010Date of Patent: June 25, 2013Assignee: Crucell Holland B.V.Inventors: Mark Throsby, Robert Heinz Edward Friesen, Theodorus Hendrikus Jacobus Kwaks, Mandy Antonia Catharina Jongeneelen
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Publication number: 20120296118Abstract: The invention relates to a method for producing and using a solid sodium diformate having a high formic acid content, to the use thereof in animal foods in the form of an acidifier, preservatives, ensilage auxiliary agents, fertilizers, and a growth and productivity-stimulating agent and the inventive animal food additives containing sodium diformate.Type: ApplicationFiled: August 3, 2012Publication date: November 22, 2012Applicant: BASF SEInventors: Robert Heinz, Otto Machhammer, Stefan Gropp, Alexander Hauk, Gerd Diebold, Anna Valeska Lohmann, Dieter Feuerstein, Robert Rühle, Rüdiger Schmitt