Abstract: A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent.

Abstract: An interface is provided for storing microfluidic samples in a nanoliter sample chip. A fluid access structure provides a fluid access region to a selected subset of sample wells from an array of sample wells. A fluid introduction mechanism introduces a sample fluid to the fluid access region so that the sample wells in the selected subset are populated with the sample fluid without the unselected sample wells being populated with the sample fluid.

Abstract: A battery state of health estimator and similar method, system and computer product is disclosed providing for a estimate of a state of health (SOH) of one or more batteries, comprising, estimating a sampling of internal resistances of the one or more batteries, generating a time history of the internal resistance over a predetermined amount of time, generating a cumulative internal resistance histogram from the time history, calculating a final estimate of internal resistance of one or more batteries which represents the calculated SOH of one or more batteries and comparing the calculated SOH to a predetermined critical resistance threshold. If the calculated SOH is less than the predetermined critical resistance threshold, the battery is in no worse than a “Blue Monday” condition, and if the calculated SOH is greater than the critical resistance threshold, then the one or more batteries has failed.

Abstract: An interface is provided for storing microfluidic samples in a nanoliter sample chip. A fluid access structure provides a fluid access region to a selected subset of sample wells from an array of sample wells. A fluid introduction mechanism introduces a sample fluid to the fluid access region so that the sample wells in the selected subset are populated with the sample fluid without the unselected sample wells being populated with the sample fluid.

Abstract: The invention features methods of making devices, or “platens”, having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. The invention further features methods of making high-density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays. The invention includes methods by which many physical, chemical or biological transformations can be implemented in serial or in parallel within each addressable through-hole of the devices. Additionally, the invention includes methods of analyzing the contents of the array, including assaying of physical properties of the samples.

Abstract: The invention features methods of making devices, or “platens”, having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. The invention further features methods of making high-density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays. The invention includes methods by which many physical, chemical or biological transformations can be implemented in serial or in parallel within each addressable through-hole of the devices. Additionally, the invention includes methods of analyzing the contents of the array, including assaying of physical properties of the samples.

Abstract: There is presented a system for determining a placement of a virtual object in a performance space according to a performance by a real-time performer. The disclosed system comprises a projection module including a polarizing filter, the projection module configured to generate a polarized visible image corresponding to the virtual object. The system includes a surface for displaying the polarized visible image to the real-time performer. The system also includes a detection module for detecting inputs to the surface, wherein the inputs are provided by the real-time performer based on a location of the polarized visible image on the surface. The system further comprises a mapping module configured for mapping a location of each input to the surface to a corresponding point in the performance space, for the placement of the virtual object in the performance space according to the locations of inputs to the surface by the real-time performer.

Abstract: There is presented a system for recording a performance by a real-time performer interacting with a virtual object. The disclosed system comprises a projection module including a polarizing filter, the projection module configured to generate a polarized visible image corresponding to the virtual object. The system includes a surface for displaying the polarized visible image, the surface viewable by the real-time performer. The system also includes a recording module including a reverse-polarizing filter, the reverse-polarizing filter configured to reverse-polarize images of the performance by the real-time performer and the surface displaying the polarized visible image to produce reverse-polarized images. The recording module is configured to record the reverse-polarized images. In one embodiment, the system further comprises a rendering module configured to render the virtual object into the recorded performance.

Abstract: A battery state of health estimator and similar method, system and computer product is disclosed providing for a estimate of a state of health (SOH) of one or more batteries, comprising, estimating a sampling of internal resistances of the one or more batteries, generating a time history of the internal resistance over a predetermined amount of time, generating a cumulative internal resistance histogram from the time history, calculated a final estimate of internal resistance of said one or more batteries which represents the calculated SOH of said one or more batteries and comparing the calculated SOH to a predetermined critical resistance threshold. If the calculated SOH is less than the predetermined critical resistance threshold, the battery is in no worse than a “Blue Monday” condition, and if the calculated SOH is greater than the critical resistance threshold, then the one or more batteries has failed.

Abstract: A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent.

Abstract: Methods for cell lysis and purification of biological materials, involving subjecting a sample to high pressure. Also featured is an apparatus for practicing the methods.

Abstract: A controller for controlling the dose rate (exposure kV tube voltage) of an X-ray system, in which the actual dose rate is measured and compared with an optimal dose rate, and the resultant difference value is fed to a module (20) (e.g. a PID module) which is arranged to adjust the dose rate (by adjusting the exposure kV voltage) so as to minimize the difference value. No preset parameters are required to be entered prior to exposure.

Abstract: A method of conducting an assay on a plurality of samples is provided. The method includes the steps of performing an assay at each sample site in a sample array having greater than 100 sample sites simultaneously illuminating each sample site using one or more LEDs, and simultaneously imaging each of the sample sites to produce imaging data pertinent to the optical effect of each site. Each assay provides an optical effect.

Abstract: A thermal cycling device and a method of thermal cycling are provided. A thermal cycling device includes a fluid device system, a case, and a cycling head. The fluid delivery system develops a flow of controlled-temperature fluid. The case has a fluid-tight cavity for holding a microfluidic array. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces. The cycling head holds the case and delivers the flow of fluid over the case.

Abstract: A controller for controlling the dose rate (exposure kV tube voltage) of an X-ray system, in which the actual dose rate is measured and compared with an optimal dose rate, and the resultant difference value is fed to a module (20) (e.g. a PID module) which is arranged to adjust the dose rate (by adjusting the exposure kV voltage) so as to minimise the difference value. No preset parameters are required to be entered prior to exposure.

Abstract: An interface is provided for storing microfluidic samples in a nanoliter sample chip. A fluid access structure provides a fluid access region to a selected subset of sample wells from an array of sample wells. A fluid introduction mechanism introduces a sample fluid to the fluid access region so that the sample wells in the selected subset are populated with the sample fluid without the unselected sample wells being populated with the sample fluid.

Abstract: A differentially coated device for conducting a plurality of nano-volume specified reactions, the device comprising a platen having at least one exterior surface modified to a specified physicochemical property, a plurality of nano-volume channels, each nano-volume channel having at least one interior surface in communication with the at least one exterior surface that is selectively coated with an optionally dissolvable coating agent physisorbed to at least one interior surface, wherein the optionally dissolvable coating agent comprises a coating agent and a first component for the plurality of specified reactions. Methods for preparing and using such devices are also provided, as well as a method of registering a location of a dispenser array in relation to a microfluidic array. A first one of the dispenser array and the microfluidic array is movable in relation to the frame, and the other of the first one of the dispenser array and the microfluidic array is fixed relative to the frame.

Abstract: Methods for cell lysis and purification of biological materials, involving subjecting a sample to high pressure. Also featured is an apparatus for practicing the methods.

Abstract: A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent.

Abstract: The invention is based on the discovery that biological and non-biological materials can be sterilized, decontaminated, or disinfected by repeatedly cycling between relatively high and low pressures. Pressure cycling can be carried out at low, ambient, or elevated temperatures (e.g., from about −40° C. to about 95° C., or intermediate ranges). New methods based on this discovery can have applications in, for example, the preparation of vaccines, the sterilization of blood plasma or serum, plant, animal, and human tissue, sputum, urine, feces, water, and ascites, the decontamination of military devices, food and beverage production, and the disinfection of medical equipment. The new methods can also be incorporated into production processes or research procedures.