Patents by Inventor Robert Hett

Robert Hett has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200369722
    Abstract: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
    Type: Application
    Filed: August 13, 2020
    Publication date: November 26, 2020
    Inventors: Vince Ammoscato, John E. Bishop, Fang-Ting Chiu, Achim Geiser, Jean-Marc Gomez, Robert Hett, Christoph Koellner, Vithalanand R. Kulkarni, Young Lo, Stephen Munk, I. Fraser Pickersgill
  • Publication number: 20200157143
    Abstract: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
    Type: Application
    Filed: January 24, 2020
    Publication date: May 21, 2020
    Inventors: Vince Ammoscato, John E. Bishop, Fang-Ting Chiu, Achim Geiser, Jean-Marc Gomez, Robert Hett, Christoph Koellner, Vithalanand R. Lulkarni, Young Lo, Stephen Munk, I.Fraser Pickersgill
  • Publication number: 20190330270
    Abstract: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
    Type: Application
    Filed: July 11, 2019
    Publication date: October 31, 2019
    Inventors: Vince Ammoscato, John E. Bishop, Fang-Ting Chiu, Achim Geiser, Jean-Marc Gomez, Robert Hett, Christoph Koellner, Vithalanand R. Kulkarni, Young Lo, Stephen Munk, I. Fraser Pickersgill
  • Publication number: 20190112334
    Abstract: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
    Type: Application
    Filed: December 13, 2018
    Publication date: April 18, 2019
  • Publication number: 20180265546
    Abstract: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
    Type: Application
    Filed: May 23, 2018
    Publication date: September 20, 2018
  • Patent number: 10000529
    Abstract: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: June 19, 2018
  • Publication number: 20180044377
    Abstract: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
    Type: Application
    Filed: September 22, 2017
    Publication date: February 15, 2018
  • Patent number: 9862745
    Abstract: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
    Type: Grant
    Filed: January 8, 2016
    Date of Patent: January 9, 2018
  • Publication number: 20160362449
    Abstract: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
    Type: Application
    Filed: January 8, 2016
    Publication date: December 15, 2016
  • Publication number: 20150038706
    Abstract: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
    Type: Application
    Filed: March 6, 2014
    Publication date: February 5, 2015
  • Publication number: 20130005968
    Abstract: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 3, 2013
  • Patent number: 8283467
    Abstract: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
    Type: Grant
    Filed: February 16, 2010
    Date of Patent: October 9, 2012
  • Patent number: 7763754
    Abstract: A process for producing (1R,3R,6R)-6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol or (1S,3S,6S)-6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol or mixtures thereof.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: July 27, 2010
    Assignee: Gruenenthal GmbH
    Inventors: Helmut Heinrich Buschmann, Wolfgang Hell, Joerg Holenz, Oswald Zimmer, Irene Vaulont, Dieter Haag, Emad El Sayed, Robert Hett, Alfed Olbrich, Lars Pumpenmeier
  • Publication number: 20100174072
    Abstract: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
    Type: Application
    Filed: February 16, 2010
    Publication date: July 8, 2010
  • Patent number: 7714159
    Abstract: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
    Type: Grant
    Filed: March 24, 2005
    Date of Patent: May 11, 2010
  • Publication number: 20090253936
    Abstract: A process for producing (1R,3R,6R)-6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol or (1S,3S,6S)-6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol or mixtures thereof.
    Type: Application
    Filed: February 27, 2009
    Publication date: October 8, 2009
    Applicant: Gruenenthal GmbH
    Inventors: Helmut Heinrich BUSCHMANN, Wolfgang Hell, Joerg Holenz, Oswald Zimmer, Irene Vaulont, Dieter Haag, Emad El Sayed, Robert Hett, Alfed Olbrich, Lars Pumpenmeier
  • Publication number: 20050240047
    Abstract: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
    Type: Application
    Filed: March 24, 2005
    Publication date: October 27, 2005
  • Publication number: 20050090543
    Abstract: Among its several embodiments, the present invention provides an improved process for the preparation of tetrahydrobenzothiepine-1,1-dioxide compounds; the provision of a process for preparing a diastereomeric mixture of tetrahydrobenzothiepine-1,1-dioxide compounds from a single diastereomer of such compounds; the provision of a process for the preparation of 3-bromo-2-substituted propionaldehyde compounds; and the provision of a process for the preparation of 3-thio-2-substituted propionaldehyde compounds.
    Type: Application
    Filed: May 19, 2004
    Publication date: April 28, 2005
    Applicant: Pharmacia Corporation
    Inventors: Kevin Babiak, Andrew Carpenter, Shine Chou, Pierre-Jean Colson, Farid Payman, Robert Hett, Christian Huber, Kevin Koeller, Jon Lawson, James Li, Eduardo Mar, Lawrence Miller, Vladislav Orlovski, James Peterson, Mark Pozzo, Claire Przybyla, Samuel Tremont, Jay Trivedi, Grace Wagner, Gerald Weisenburger, Benxin Zhi
  • Patent number: 6794544
    Abstract: Among its several embodiments, the present invention provides an improved process for the preparation of tetrahydrobenzothiepine-1,1-dioxide compounds; the provision of a process for preparing a diastereomeric mixture of tetrahydrobenzothiepine-1,1-dioxide compounds from a single diastereomer of such compounds; the provision of a process for the preparation of 3-bromo-2-substituted propionaldehyde compounds; and the provision of a process for the preparation of 3-thio-2-substituted propionaldehyde compounds.
    Type: Grant
    Filed: December 23, 2002
    Date of Patent: September 21, 2004
    Assignee: Pharmacia Corporation
    Inventors: Kevin A. Babiak, Andrew Carpenter, Shine Chou, Pierre-Jean Colson, Payman Farid, Robert Hett, Christian H. Huber, Kevin J. Koeller, Jon P. Lawson, James Li, Eduardo K. Mar, Lawrence M. Miller, Vladislav Orlovski, James C. Peterson, Mark J. Pozzo, Claire A. Przybyla, Samuel J. Tremont, Jay S. Trivedi, Grace M. Wagner, Gerald A. Weisenburger, Benxin Zhi
  • Publication number: 20040082647
    Abstract: Among its several embodiments, the present invention provides an improved process for the preparation of tetrahydrobenzothiepine-1,1-dioxide compounds; the provision of a process for preparing a diastereomeric mixture of tetrahydrobenzothiepine-1,1-dioxide compounds from a single diastereomer of such compounds; the provision of a process for the preparation of 3-bromo-2-substituted propionaldehyde compounds; and the provision of a process for the preparation of 3-thio-2-substituted propionaldehyde compounds.
    Type: Application
    Filed: April 21, 2003
    Publication date: April 29, 2004
    Applicant: G.D. SEARLE, LLC
    Inventors: Kevin A. Babiak, Andrew Carpenter, Shine Chou, Pierre-Jean Colson, Payman Farid, Robert Hett, Christian H. Huber, Kevin J. Koeller, Jon P. Lawson, James Li, Eduardo K. Mar, Lawrence M. Miller, Vladislav Orlovski, James C. Peterson, Mark J. Pozzo, Claire A. Przybyla, Samuel J. Tremont, Jay S. Trivedi, Grace M. Wagner, Gerald A. Weisenburger, Benxin Zhi