Patents by Inventor Robert Higuchi

Robert Higuchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GPR35 modulators
    Patent number: 11773101
    Abstract: Described herein are GPR35 modulators and methods of using these compounds in the treatment of diseases, disorders or conditions. Also described herein are pharmaceutical compositions containing such compounds.
    Type: Grant
    Filed: May 18, 2021
    Date of Patent: October 3, 2023
    Assignee: Prometheus Biosciences, Inc.
    Inventor: Robert Higuchi
  • THERAPEUTIC AGENTS TARGETING GPR35
    Publication number: 20230151017
    Abstract: Described herein are GPR35 modulators and methods of using these compounds in the treatment of diseases, disorders or conditions. Also described herein are pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: January 20, 2023
    Publication date: May 18, 2023
    Inventors: Robert HIGUCHI, Michael BISHOP
  • GPR35 MODULATORS
    Publication number: 20210380590
    Abstract: Described herein are GPR35 modulators and methods of using these compounds in the treatment of diseases, disorders or conditions. Also described herein are pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: May 18, 2021
    Publication date: December 9, 2021
    Inventor: Robert Higuchi
  • GPR35 modulators
    Patent number: 11053251
    Abstract: Described herein are GPR35 modulators and methods of using these compounds in the treatment of diseases, disorders or conditions. Also described herein are pharmaceutical compositions containing such compounds.
    Type: Grant
    Filed: January 23, 2020
    Date of Patent: July 6, 2021
    Assignee: Prometheus Biosciences, Inc.
    Inventor: Robert Higuchi
  • GPR35 MODULATORS
    Publication number: 20200239476
    Abstract: Described herein are GPR35 modulators and methods of using these compounds in the treatment of diseases, disorders or conditions. Also described herein are pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: January 23, 2020
    Publication date: July 30, 2020
    Inventor: Robert Higuchi
  • Boron containing polybasic bacterial efflux pump inhibitors and therapeutic uses thereof
    Patent number: 8933018
    Abstract: Disclosed herein are polybasic bacterial efflux pump inhibitors containing boronic acid functionality and their methods of synthesis, methods of use, and pharmaceutical compositions. Some embodiments include methods of treating or preventing a bacterial infection by co-administering to a subject infected with bacteria or at risk of infection with bacteria the efflux pump inhibitor with another anti-bacterial agent.
    Type: Grant
    Filed: February 6, 2012
    Date of Patent: January 13, 2015
    Assignee: Rempex Pharmaceuticals, Inc.
    Inventors: Tomasz Glinka, Robert Higuchi, Scott Hecker, Brian Eastman, Olga Rodny
  • BORON CONTAINING POLYBASIC BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTIC USES THEREOF
    Publication number: 20130316943
    Abstract: Disclosed herein are polybasic bacterial efflux pump inhibitors containing boronic acid functionality and their methods of synthesis, methods of use, and pharmaceutical compositions. Some embodiments include methods of treating or preventing a bacterial infection by co-administering to a subject infected with bacteria or at risk of infection with bacteria the efflux pump inhibitor with another anti-bacterial agent.
    Type: Application
    Filed: February 6, 2012
    Publication date: November 28, 2013
    Applicant: REMPEX PHARMACEUTICALS, INC.
    Inventors: Tomasz Glinka, Robert Higuchi, Scott Hecker, Brian Eastman, Olga Rodny
  • Bicyclic androgen and progesterone receptor modulator compounds and methods
    Publication number: 20110112084
    Abstract: The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR and PR. More particularly, the invention relates to nonsteroidal compounds and compositions that are high affinity, high specificity agonists, partial agonists (i.e., partial activators and/or tissue-specific activators) and antagonists for AR and PR. Also provided are methods of making such compounds and pharmaceutical compositions, as well as critical intermediates used in their synthesis.
    Type: Application
    Filed: November 13, 2009
    Publication date: May 12, 2011
    Inventors: Lin Zhi, Christopher Tegley, Barbara Pio, Corneils Arjan Van Oeveren, Mehrnouch Motamedi, Esther Martinborough, Robert Higuchi, Lawrence G. Hamann
  • Bicyclic androgen and progesterone receptor modulator compounds and methods
    Publication number: 20100069379
    Abstract: The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR and PR. More particularly, the invention relates to nonsteroidal compounds and compositions that are high affinity, high specificity agonists, partial agonists (i.e., partial activators and/or tissue-specific activators) and antagonists for AR and PR. Also provided are methods of making such compounds and pharmaceutical compositions, as well as critical intermediates used in their synthesis.
    Type: Application
    Filed: November 13, 2009
    Publication date: March 18, 2010
    Inventors: Lin Zhi, Christopher Tegley, Barbara Pio, Corneils Arjan Van Oeveren, Mehrnouch Motamedi, Esther Martinborough, Robert Higuchi, Lawrence G. Hamann
  • Glucocorticoid Receptor Modulator Compounds and Methods
    Publication number: 20090105292
    Abstract: Disclosed herein are compounds of Formula I: and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof. Certain of such compounds are selective glucocorticoid receptor modulators and/or selective glucocorticoid binding agents. Also disclosed are methods of making and using such compounds, including, but not limited to, using such compounds for treating various conditions.
    Type: Application
    Filed: February 24, 2005
    Publication date: April 23, 2009
    Applicant: LIGAND PHARMACEUTICALS INCORPORATED
    Inventors: Lin Zhi, Robert Ardecky, Dean Phillips, John Tyhonas, Donald Karanewsky, Robert Higuchi, A.R. Hudson, S.L. Roach, A.C. Vassar, Yongkai Li, Mark Adams, L.J. Valdez, C. Cuervo
  • Tricyclic quinolinone and tricyclic quinoline androgen receptor modulator compounds and methods
    Publication number: 20080300241
    Abstract: Non-steroidal tricyclic quinolinone and tricyclic quinoline compounds and compositions that are agonists, partial agonists and/or antagonists for androgen receptors (AR), their preparation and their uses are described.
    Type: Application
    Filed: November 17, 2006
    Publication date: December 4, 2008
    Inventors: Robert Higuchi, Lin Zhi, Donald Karanewsky, Anthony Thompson, Thomas Caferro, Neelakandha Mani, Jyun-Hung Chen, Marquis Cummings, James Edwards, Mark Adams, Charlotte Deckhut
  • Tricyclic androgen receptor modulator compounds and methods
    Publication number: 20070293528
    Abstract: This invention relates to non-steroidal tricyclic compounds that are modulators of androgen receptors and to methods for making and using such compounds.
    Type: Application
    Filed: January 31, 2006
    Publication date: December 20, 2007
    Inventors: Lin Zhi, Cornelis Van Oeveren, Jyun-Hung Chen, Robert Higuchi
  • INTRACELLULAR RECEPTOR MODULATOR COMPOUNDS AND METHODS
    Publication number: 20070254917
    Abstract: This invention relates to compounds that bind to intracellular receptors and/or modulate activity of intracellular receptors, and to methods for making and using such compounds.
    Type: Application
    Filed: January 12, 2007
    Publication date: November 1, 2007
    Inventors: Robert Higuchi, Steven Roach, Lin Zhi, Mark Adams, Yan Liu, Donald Karanewsky, Andrew Hudson
  • Androgen Receptor Modulator Compounds and Methods
    Publication number: 20070254875
    Abstract: Provided herein are compounds having a structure selected from among Formula (I), Formula (II), Formula (III), Formula (IV), Formula (V) and Formula (VI) that are androgen receptor modulators and/or androgen receptor binding agents. Also disclosed are methods of making and using such compounds, including, but not limited to, using such compounds for treating various conditions.
    Type: Application
    Filed: March 11, 2005
    Publication date: November 1, 2007
    Inventors: Lin Zhi, Robert Higuchi, E. Kallel, Cornelis Van Oeveren, Jyun-Hung Chen, Daniel Ruppar, Bijan Pedram, Thomas Stevens Lau, T. Miller
  • MINERALOCORTICOID RECEPTOR MODULATOR COMPOUNDS, PROCESSES FOR THEIR PREPARATION, AND THEIR USES
    Publication number: 20070197520
    Abstract: This invention relates to compounds that bind to mineralocorticoid receptors and/or modulate activity of mineralocorticoid receptors, and to methods for making and using such compounds.
    Type: Application
    Filed: January 12, 2007
    Publication date: August 23, 2007
    Inventors: Robert Higuchi, Lin Zhi, Mark Adams, Yan Liu, Donald Karanewsky
  • MINERALOCORTICOID RECEPTOR MODULATOR COMPOUNDS AND METHODS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS
    Publication number: 20070185102
    Abstract: This invention relates to compounds that bind to mineralocorticoid receptors and/or modulate activity of mineralocorticoid receptors, and to methods for making and using such compounds.
    Type: Application
    Filed: January 12, 2007
    Publication date: August 9, 2007
    Inventors: Robert Higuchi, Lin Zhi, Donald Karanewsky
  • Androgen receptor modulator compounds and methods
    Publication number: 20070167445
    Abstract: Compounds, pharmaceutical compositions, and methods for modulating processes mediated by steroid receptors. In particular, preparation and methods of use of non-steroidal compounds and compositions that are agonists, partial agonists, and antagonists for the androgen receptor (AR) are described. Further, described are the methods of making and use of critical intermediates including a stereoselective synthetic route to intermediates for the AR modulators.
    Type: Application
    Filed: January 25, 2006
    Publication date: July 19, 2007
    Inventors: Robert Higuchi, Kristen Arienti, Neelakandha Mani, Barbara Pio, Lin Zhi, Penghui Chen, Thomas Caferro
  • Tricyclic quinolinone and tricyclic quinoline androgen receptor modulator compounds and methods
    Publication number: 20070072849
    Abstract: Non-steroidal tricyclic quinolinone and tricyclic quinoline compounds and compositions that are agonists, partial agonists and/or antagonists for androgen receptors (AR), their preparation and their uses are described.
    Type: Application
    Filed: November 17, 2006
    Publication date: March 29, 2007
    Inventors: Robert Higuchi, Lin Zhi, Donald Karanewsky, Anthony Thompson, Thomas Caferro, Neelakandha Mani, Jyun-Hung Chen, Marquis Cummings, James Edwards, Mark Adams, Charlotte Deckhut
  • Tricyclic androgen receptor modulator compounds and methods
    Publication number: 20060128740
    Abstract: This invention relates to non-steroidal tricyclic compounds that are modulators of androgen receptors and to methods for making and using such compounds.
    Type: Application
    Filed: January 31, 2006
    Publication date: June 15, 2006
    Inventors: Lin Zhi, Cornelis Van Oeveren, Jyun-Hung Chen, Robert Higuchi
  • Androgen receptor modulator compounds and methods
    Publication number: 20030186970
    Abstract: Compounds, pharmaceutical compositions, and methods for modulating processes mediated by steroid receptors. In particular, preparation and methods of use of non-steroidal compounds and compositions that are agonists, partial agonists, and antagonists for the androgen receptor (AR) are described. Further, described are the methods of making and use of critical intermediates including a stereoselective synthetic route to intermediates for the AR modulators.
    Type: Application
    Filed: September 9, 2002
    Publication date: October 2, 2003
    Inventors: Robert Higuchi, Kristen L. Arienti, Mani Neelakandha, Barbara Pio, Lin Zhi, Penghui Chen, Thomas R. Caferro