Abstract: Embodiments of the present invention generally relate to compositions and methods for targeting Semaphorin 7a (SEMA7A) in health conditions. In certain embodiments, compositions and methods disclosed herein concern using SEMA7A targeting for diagnosis and treatment of cancers, cardiac conditions, and other health conditions. In some embodiments, SEMA7A peptide fragments and fusion polypeptides can be used to generate antibodies of use to diagnose, reduce metastasis and treat conditions disclosed herein. In certain embodiments, SEMA7A levels can be determined to project progression of a condition. In some embodiments, cancers can be targeted. In other embodiments, cancer stem cells can be targeted. In certain embodiments, SEMA7A levels can be assessed in breast cancers. In other embodiments, monoclonal antibodies against SEMA7A polypeptides can be used to treat cancers such as breast cancer and other cancers having aberrant SEMA7A expression in a subject.

Abstract: The invention provides high-yield protein dimerization methods using highly reactive bis-thioimidates that may be used in the manufacture of a highly potent anti-cancer peptide dimers.

Abstract: Gauge system, including methods and apparatus, for positioning workpieces to be processed. In some embodiments, the gauge system may have a plurality of stops for positioning the end of a workpiece at distinct distances from a processing station. In some embodiments, the plurality of stops may be arrayed along a rail assembly having an adjustable length.

Abstract: A semiconductor structure comprises a silicon substrate of a first conductivity type including wells of a second conductivity type formed on a surface thereof. The wells may be laterally isolated by shallow trench isolation. Transistors are formed in the wells by first forming several chemically distinct layers. Anisotropic etching then forms openings in a top one of the layers. A blanket dielectric layer is formed in the openings and on the layers. Anisotropic etching removes portions of the blanket dielectric layer from planar surfaces of the substrate but not from sidewalls of the openings to form dielectric spacers separated by gaps within the openings. Gate oxides are formed by oxidation of exposed areas of the substrate. Ion implantation forms channels beneath the gate oxides. Polysilicon deposition followed by chemical-mechanical polishing defines gates in the gaps. The chemically distinct layers are then stripped without removing the dielectric spacers.

Abstract: A process for irrigation involves monitoring reclaimed water, and treating it when necessary. The reclaimed water is tested with monitors to obtain results for water quality characteristics, including: pH; residual chlorine; and, sodium. These results are inputted to a computerized data handling system for data collection, storage and analysis for comparison to predetermined acceptable ranges for water quality characteristic, and to show any deviation from said acceptable ranges. Either alarms are set off or treatment occurs or both, when deviations are observed. Treatment includes a dechlorination system to correct active chlorine, and, optionally, an oxidation system. There is also a reverse osmosis step for reduction of salts, such as sodium. Other monitors may include one or more of hardness; turbidity; alkalinity; conductivity and nitrates.

Abstract: The invention relates to the use of constrained coiled-coil polypeptides to mimic ?-helical structural elements of native proteins. These constrained peptidyl mimetics are used to generate and/or identify ligands which selectively bind the ?-helical segment contained in the native protein.

Abstract: The process for irrigation of a man-made landscaped area, such as a golf course, playing field or agricultural area, involves monitoring a sample of reclaimed water, a sample of soil containing reclaimed water, or both from a supply of reclaimed water, and treating it when necessary to avoid harmful effects to plantlife, and irrigating with the treated water via a subterranean distribution system. The sample is tested with monitors for water quality characteristics, including: total organic carbon compounds; pH; residual chlorine; chlorides; and, sodium. These results are inputted to a computerized data handling system for data collection, storage and analysis for comparison to predetermined acceptable ranges to show deviation from acceptable ranges. Either alarms are set off or treatment occurs or both, when deviations are observed. Treatment may include a dechlorination system, an oxidation system, reverse osmosis system. Other monitors may be for hardness; turbidity; alkalinity; conductivity and nitrates.

Abstract: Peptide compositions and methods of producing and using same are provided. The peptide compositions are based on pilin peptides derived from Pseudomonas aeruginosa. The compositions include antigens and antibodies immunoreactive against the antigens. The compositions can be utilized in vaccines for treatment purposes, such as to treat or prevent infection associated with Pseudomonas aeruginosa and/or other infectious agents. Further, the compositions can be utilized to produce antibody or monoclonal antibody therapeutic to treat or prevent infection associated with Pseudomonas aeruginosa and/or other infectious agents.

Abstract: The present invention is process for irrigation of a golf course, which involves monitoring reclaimed water, and treating it when necessary to avoid harmful effects to plantlife. The reclaimed water is tested with a plurality of monitors to obtain results for water quality characteristics, including: total organic carbon compounds; pH; residual chlorine; chlorides; and, sodium. These results are inputted to a computerized data handling system for data collection, storage and analysis for comparison to predetermined acceptable ranges for water quality characteristic, and to show any deviation from said acceptable ranges. Either alarms are set off or treatment occurs or both, when deviations are observed. Treatment includes a dechlorination system and an oxidation system to correct active chlorine and total organic compound levels, respectively. Other important monitors may be included for one or more of the following: hardness; turbidity; alkalinity; conductivity and nitrates.

Abstract: The present invention is process for irrigation of a golf course, which involves monitoring reclaimed water, and treating it when necessary to avoid harmful effects to plantlike. The reclaimed water is tested with a plurality of monitors to obtain results for water quality characteristics, including: total organic carbon compounds; pH; residual chlorine; chlorides; and, sodium. These results are inputted to a computerized data handling system for data collection, storage and analysis for comparison to predetermined acceptable ranges for water quality characteristic, and to show any deviation from said acceptable ranges. Either alarms are set off or treatment occurs or both, when deviations are observed. Treatment includes a dechlorination system and an oxidation system to correct active chlorine and total organic compound levels, respectively. Other important monitors may be included for one or more of the following: hardness; turbidity; alkalinity; conductivity and nitrates.

Abstract: This invention relates to the use of a coiled-coil structural scaffold to generate structure-specific peptides, including synthetic peptides derived from naturally occurring proteins of various origin. The structure of the synthetic peptides utilizes a scaffold of heptad repeat units into which epitopes from coiled-coil regions of native proteins are spliced. In particular, the synthetic peptides may be based on microbial proteins, especially surface proteins, which occur naturally in the coiled-coil form such as pneumococcal surface proteins A and C. The synthetic peptides are immunogenic and can be used to elicit an immune response in an animal. Accordingly, they are useful as vaccines or to stimulate antibody production or cell-mediated immunity to the naturally occurring protein.

Abstract: A method of forming an isolation region in an integrated circuit and an integrated circuit formed thereby. A method preferably includes forming at least one trench in a semiconductor substrate, forming an insulation layer of material in the at least one trench and on peripheral regions of the at least one trench of the semiconductor substrate, forming a sacrificial layer of material on the insulation layer having a different polishing rate than the insulation layer, and polishing the layer having the different polishing rate and portions of the insulation layer so that the sacrificial layer having the different polishing rate and portions of the insulation layer are removed, so that other portions of the insulation layer remain in the at least one trench of the substrate, and so that the upper surface of the at least one trench and the peripheral regions thereof in combination provide a substantially planar surface.

Abstract: A method of forming an isolation region in an integrated circuit and an integrated circuit formed thereby. A method preferably includes forming at least one trench in a semiconductor substrate, forming an insulation layer of material in the at least one trench and on peripheral regions of the at least one trench of the semiconductor substrate, forming a sacrificial layer of material on the insulation layer having a different polishing rate than the insulation layer, and polishing the layer having the different polishing rate and portions of the insulation layer so that the sacrificial layer having the different polishing rate and portions of the insulation layer are removed, so that other portions of the insulation layer remain in the at least one trench of the substrate, and so that the upper surface of the at least one trench and the peripheral regions thereof in combination provide a substantially planar surface.

Abstract: A set of goggles comprising a lens holder including a pair of confronting straps having aligned lens apertures therein which receive lens. The straps are coupled together along the bottom, side and outer top confronting edges but are separated at a central, upper passage which is wider than the width of each lens but narrower than twice the width of each lens. Mechanism is provided for detachably coupling the lens holder to headgear, such as a helmet or a bandanna, and includes side bands that are coupled to opposite ends of the straps and extend along the sides of the head of a user. The bands can be detachably coupled to complementally formed fasteners provided on the helmet or bandanna. The side bands include forward portions folded over upon themselves and coupled to the ends of the straps.

Abstract: A method is provided for forming isolated regions of oxide of an integrated circuit, and an integrated circuit formed according to the same. A pad oxide layer is formed over the integrated circuit. A nitrogen doped polysilicon layer is formed over the pad oxide layer. A thick nitride layer is then formed over the nitrogen doped polysilicon layer. An opening is formed in the nitride layer and the nitrogen doped polysilicon layer exposing a portion of the pad oxide layer. The nitrogen doped polysilicon layer is annealed encapsulating the polysilicon layer in silicon nitride. A field oxide region is then formed in the opening.

Abstract: A method is provided for forming isolated regions of oxide of an integrated circuit, and an integrated circuit formed according to the same. A pad oxide layer is formed over the integrated circuit. A nitrogen doped polysilicon layer is formed over the pad oxide layer. A thick nitride layer is then formed over the nitrogen doped polysilicon layer. An opening is formed in the nitride layer and the nitrogen doped polysilicon layer exposing a portion of the pad oxide layer. The nitrogen doped polysilicon layer is annealed encapsulating the polysilicon layer in silicon nitride. A field oxide region is then formed in the opening.