Abstract: The invention relates to the use of a sphingosine-1-phosphate receptor agonist in the treatment of heart diseases.

Abstract: The invention relates to a process for the conversion of group X in a 2-(6-substituted)-1,3-dioxane-4yl) acetic acid derivative according to formula 2 into a group OY in the presence of a phase transfer catalyst and an oxylating agent, by using as a phase transfer catalyst a quarternary phosphonium ion and by using as an oxylating agent an OY-ion. X stands for a halogen and R1, R2 and R3 are each independently a C1-4 alkylgroup or R1 and R2 together with the C-atom to which they are bound form a 5- or 6-membered cycloalkyl; Y stands for RA-CO— or for RB—SO2- with RA, RB are chosen from the group of alkyl or aryl with 1-12 C-atoms.

Abstract: Packaging (1) for the extemporaneous mixing of two products (A, B) includes a first bottle (6) intended to contain a first product (A), this bottle being open at its base (12) in the form of a skirt (7) and being fitted with a dispensing nozzle (36); a connecting part (10) fixed to the base (12) of the first bottle (6), including a central hollow shaft (14) capable of receiving a first detachable stopper (16) allowing the first bottle to be closed; a second bottle (5) intended to contain a second product (B), provided with a neck (18) which can be engaged in the central hollow shaft (14), the second bottle (5) being equipped with a removable closure (26) and bearing an engagement part (48) which, after the closure (26) has been removed, interacts with a complementary part (46) provided in the central hollow shaft (14), to allow the first stopper (16) to be expelled and allow the two products (A+B) to be mixed.