Abstract: Compounds having the structure of Formula (I): and pharmaceutically acceptable salts thereof, wherein X1, R1, R2, R3, R4, R5 and R6 are as defined in the specification; pharmaceutical compositions comprising such compounds and salts; use of such compounds and salts to treat or prevent Prolyl endopeptidase fibroblast activation protein (FAP)-mediated conditions; kits comprising such compounds and salts; and methods for manufacturing such compounds and salts.

Abstract: A portable, handheld device for manual percussive respiratory therapy in infants and young children having a pear-shaped dome for proper position of the device over various sizes of target treatment anatomy, an ergonomic handle for maximum efficacy in implementation by a range of users, a cushioned sealing mechanism for softening the impact on a young patient, and indicator means to indicate proper positioning and engagement of the device during use. The device is optimal for use by parents and other caregivers with little or no medical training.