Abstract: The invention relates to an axle structure for a motor vehicle, preferably a utility vehicle, for installing a first wheel and a second wheel. The axle structure has a longitudinal axis and defines a vertical reference plane which extends along the longitudinal axis, and the axle structure comprises a first brake cylinder, which preferably has a first central line and is preferably used to brake the first wheel, and a second brake cylinder, which preferably has a second central line and is preferably used to brake the second wheel. The axle structure is characterized in particular in that the first brake cylinder is arranged on one side of the reference plane, and the second brake cylinder is arranged on the other side of the reference plane.

Abstract: The present invention relates to methods to use non-steroidal ligands in nuclear receptor-based inducible gene expression system to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.

Abstract: The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.

Abstract: The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.

Abstract: The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.

Abstract: The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.

Abstract: A digital input device has a thimble worn on a finger and operated as a mouse for displacement encoding or as a pointer for angular encoding, using a base unit. The thimble can also be attached to a stylus to form a tracing pen or joystick handle. A sensor preferably includes a contact roller at an end of the thimble that rotates with movement over a surface. The sensor emits a signal as a function of incremental displacement of the sensor over a surface, in X and Y directions. The sensor couples to the base unit at a universal joint and the base unit has a cup-shaped contact surface for encoding angular displacement around the universal joint, using displacement of the sensor over the cup-shaped surface. The contact roller is mechanically arranged to pass a coding strip having reflective, transmissive or magnetic stripes before a sensing element. The sensor can be pivoted back on the finger to enable typing.