Abstract: Disclosed herein are methods, devices, compositions, and systems for providing an interface between medical instrumentation and a patient. In various embodiments, the interface provides a sterile barrier, acoustic coupler, and thermal insulator between the patient and a medical instrument. In some embodiments, an acoustic coupler interface is used between an ultrasound instrument and a patient. In some embodiments, the acoustic coupler comprises a thermoplastic elastomer (“TPE”) and in particular oil-enhanced or gelatinous TPEs that can be used in diagnostic and therapeutic (HIFU) ultrasound procedures.

Abstract: A needle-free injection device capable of delivering pressurized injections to an injection site. The device may include a barrier dispenser configured to provide a disposable piece of barrier material for each injection, so as to reduce risk of cross-contamination. The device may also include various sensors, a firing disable mechanism, a multiple use and/or disposable fluid path, and/or other mechanisms configured to enhance sterility and prevent contamination.