Abstract: Methods for screening therapeutic agents for activity against dormant cancer cells, therapeutic agents identified by the methods, and treatment methods related to the same, and methods for screening therapeutic agents for activity against microscopic metastatic tumor cancer cells, therapeutic agents identified by the methods, and treatment methods related to the same.

Abstract: Described are coelenterazine analogues, methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays. For example, the compounds may be used for in vivo imaging.

Abstract: Embodiments of the systems and methods disclosed herein provide a private broadcast platform architecture including a web server communication module, an access module, and an external communications module. The web server communication module receives an encrypted request data packet and sends a resource request message to the access module. The access module receives the resource request message and generate a resource transcoding request message. The external communications module receives the resource transcoding request message and in response, displays a broadcast platform resource data packet stream in a web page for display to a first user.

Abstract: Embodiments of the systems and methods disclosed herein provide a private broadcast platform architecture including a web server communication module, an access module, and an external communications module. The web server communication module receives an encrypted request data packet and sends a resource request message to the access module. The access module receives the resource request message and generate a resource transcoding request message. The external communications module receives the resource transcoding request message and in response, displays a broadcast platform resource data packet stream in a web page for display to a first user.

Abstract: A locking apparatus for use in securing a pivotably mounted lid of a refuse container includes a clamp assembly rotatably mounted to the container's handle and having a fork member, an arm coupled to the clamp assembly and in contact with the lid, a ring slidably mounted to the arm and clamp assembly, a mounting bracket coupled to the container's handle and connected to the clamp assembly by at least one spring, the mounting bracket having a base plate and an upper portion of the mounting bracket having at least one bumper, a rod fastener coupled to the base plate and fork member, and a rod member slidably mounted to the rod fastener. The rod member adjusts to permit the clamp assembly and arm to rotate such that the bumper releases the ring from the arm and clamp assembly upon contact, thereby enabling the container's lid to open.

Abstract: A system for dynamic geofence determination for trip navigation comprises an interface and a microprocessor. The interface is configured to receive data for one or more trips. The microprocessor is configured to determine an initial node for each trip based on the data; determine an initial time window for each trip associated with the interface; and determine a dynamic geofence for the initiation of each trip. A dynamic geofence is operable only during its initial time window. The system may have a location sensing device, such as a global positioning system. Trips may be automatically initiated when the interface is within a dynamic geofence during its initial time window.

Abstract: Methods and apparatus are disclosed to self-configure a flexible residential gateway providing access to an external communications network, and providing communications with an in home network. An example flexible residential gateway may include at least one voice over Internet protocol (IP) (VoIP) processor, at least one VoIP coupler connecting VoIP signals between at least one VoIP processor and at least one telephone line. In such an arrangement, the VoIP coupler may be configurably capable to disconnect a battery feed voltage and ring voltages from a telephone line. The gateway may further include a switch controller capable of disconnecting the battery feed voltage and the ring voltages from at least one telephone line if POTS signals are detected on at least one telephone line.

Abstract: Methods and apparatus are disclosed to self-configure a flexible residential gateway providing access to an external communications network, and providing communications with an in home network. An example flexible residential gateway may include an xDSL (“x” variety of Digital Subscriber Line) processor that processes xDSL signals communicated with the connected external communications network; a Wide area network (WAN) Ethernet transceiver that processes Ethernet signals communicated with the connected external communications network; and a switch controller that is capable of selecting either the xDSL processor or the WAN Ethernet transceiver, and if the xDSL processor is selected whether the xDSL processor is connected to a first telephone line or a coaxial cable.

Abstract: Methods and apparatus are disclosed to self-configure a flexible residential gateway providing access to an external communications network, and providing communications with an in home network. An example flexible residential gateway may include an xDSL (“x” variety of Digital Subscriber Line) processor that processes xDSL signals communicated with the external network via a first telephone line, a Home PhoneLine Networking Alliance (HomePNA) processor that processes HomePNA signals communicated with the in home network using at least one of the first or additional telephone lines, and a switch controller capable of disconnecting the HomePNA processor from at least one telephone line if Very high speed Digital Subscriber Line (VDSL) signals that interfere with the HomePNA signals are present on at least one telephone line.

Abstract: A method and apparatus for generating universal splice point adapters, where during a splicing operation an “out-point splicing adapter” is used to transition from an exit stream, while an “in-point splicing adapter” is used to transition to an entry stream.

Abstract: A method and apparatus for creating multiple unique copies of content is disclosed. In one embodiment, at least two content versions are provided. The at least two content versions are alternated in order to provide uniquely marked content. In another embodiment, a plurality of content versions are provided. Content is unlocked in accordance with a keyset. In another embodiment, a content stream having a plurality of segments is provided. One or more segments are selected from the content stream in accordance with a keyset.

Abstract: An Intelligent Issue Reporting Process has an interface to guide the process, as shown in FIGS. 1-7. The process allows reporting as shown in FIGS. 3-4, and produces reports as shown in FIGS. 5-7.

Abstract: A new computer implemented method for discovering structure-activity relationships has been discovered which utilizes weighted 2D fingerprints in conjunction with the PLS statistical methodology. This method produces a robust QSAR technique that can be automated. In addition, the MOLECULAR HOLOGRAM QSAR technique generates high quality QSAR models that are in many cases as good as or better than models arising from use of more complex and time consuming techniques such as CoMFA or Apex-3D.

Abstract: A new computer implemented method for discovering structure-activity relationships has been discovered which utilizes weighted 2D fingerprints in conjunction with the PLS statistical methodology. This method produces a robust QSAR technique that can be automated. In addition, the MOLECULAR HOLOGRAM QSAR technique generates high quality QSAR models that are in many cases as good as or better than models arising from use of more complex and time consuming techniques such as CoMFA or Apex-3D.