Patents by Inventor Robert I. Barnes

Robert I. Barnes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Drug screen for identifying an agent that modulates low density lipoprotein receptor adaptin-ligand binding
    Patent number: 6465196
    Abstract: Low density lipoprotein receptor (LDRL) adaptin is a novel, key component of human cholesterol regulation, which provides a target for rational drug design and screening, therapeutic intervention, and diagnosis. Disclosed reagents include a variety of LDLR adaptin and LDLR adaptin PTB and CC domain compositions, including in vitro compositions comprising a natural human LDLR adaptin PTB domain and a ligand such as an NPXY (SEQ ID NO:7) peptide. These LDLR adaptin reagents are used, inter alia, in rational drug screening methods. The invention also provides polynucleotides encoding the subject LDLR adaptin polypeptides, including natural coding sequences, which may be used as probes or primers for detecting or amplifying LDLR adaptin genes and transcripts.
    Type: Grant
    Filed: March 13, 2001
    Date of Patent: October 15, 2002
    Assignee: Board of Regents, The University of Texas System
    Inventors: Helen H. Hobbs, Christine K. Garcia, Robert I. Barnes, Jonathan Cohen