Patents by Inventor Robert Ivkov
Robert Ivkov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200155682Abstract: Iron oxide nanoparticle compositions, methods of preparing the nanoparticles using high gravity controlled precipitation (HGCP), and methods of using the nanoparticles are disclosed.Type: ApplicationFiled: July 25, 2019Publication date: May 21, 2020Inventor: ROBERT IVKOV
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Patent number: 10406228Abstract: Iron oxide nanoparticle compositions, methods of preparing the nanoparticles using high gravity controlled precipitation (HGCP), and methods of using the nanoparticles are disclosed.Type: GrantFiled: November 27, 2013Date of Patent: September 10, 2019Assignee: THE JOHNS HOPKINS UNIVERSITYInventor: Robert Ivkov
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Publication number: 20160271274Abstract: Magnetic iron oxide nanoparticles (MIONs) having silica (SiMION) and gold-silica (AuSiMION) nanoshells, methods of their preparation, and their use in cancer imaging and therapy applications are disclosed.Type: ApplicationFiled: November 7, 2014Publication date: September 22, 2016Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: ROBERT IVKOV, LAUREN WOODARD, MARTIN G. POMPER
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Patent number: 9333369Abstract: An apparatus for exposing a region of interest of an object, animal or person to an alternating magnetic field has a source of radio-frequency electromagnetic radiation arranged to provide the alternating magnetic field in an exposure volume defined by the apparatus, and a shield arranged between the source of radio-frequency electromagnetic radiation and the exposure volume. The shield includes a material that has a sufficient thickness and arrangement to reduce power deposition to at least regions outside of the region of interest of the object, animal or person during exposure in the exposure volume.Type: GrantFiled: October 22, 2010Date of Patent: May 10, 2016Assignee: The Johns Hopkins UniversityInventors: Robert Ivkov, Ananda Kumar
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Publication number: 20150320862Abstract: Iron oxide nanoparticle compositions, methods of preparing the nanoparticles using high gravity controlled precipitation (HGCP), and methods of using the nanoparticles are disclosed.Type: ApplicationFiled: November 27, 2013Publication date: November 12, 2015Applicants: NANOMATERIALS TECHNOLOGY PTE LTD, THE JOHNS HOPKINS UNIVERSITYInventors: ROBERT IVKOV, YIT WOOI GOH, MENG TACK NG, ZHIGANG SHEN, SUNG LAI JIMMY YUN
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Publication number: 20120277517Abstract: An embodiment in accordance with the present invention provides a thermo-chemoembolization formulation and method for enhanced interventional image-guided therapy for cancer. The T-C formulation includes magnetic iron oxide nano-particles (MIONs) that heat when exposed to an alternating magnetic field (AMF), a liquid tumorphilic drug carrier that enhances tumor retention of the T-C formulation, and a chemotherapeutic or radiotherapeutic agent. The T-C formulation enhances delivery of heat and chemo- or radio-therapeutic agents with hyperthermia produced by magnetic nanoparticles to improve therapeutic outcomes. The magnetic nanoparticles and tumorphilic drug carrier also allow for multimodal image-guided monitoring of treatment and patient follow-up. The method for enhanced interventional image-guided therapy for cancer includes using an AMF to heat the T-C formulation and activate the thermotherapy.Type: ApplicationFiled: April 9, 2012Publication date: November 1, 2012Applicant: The Johns Hopkins UniversityInventors: Robert Ivkov, Eleni Liapi
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Publication number: 20120265000Abstract: An apparatus for exposing a region of interest of an object, animal or person to an alternating magnetic field has a source of radio-frequency electromagnetic radiation arranged to provide the alternating magnetic field in an exposure volume defined by the apparatus, and a shield arranged between the source of radio-frequency electromagnetic radiation and the exposure volume. The shield includes a material that has a sufficient thickness and arrangement to reduce power deposition to at least regions outside of the region of interest of the object, animal or person during exposure in the exposure volume.Type: ApplicationFiled: October 22, 2010Publication date: October 18, 2012Applicant: The Johns Hopkins UniversityInventors: Robert Ivkov, Ananda Kumar
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Patent number: 7731648Abstract: Disclosed are thermotherapeutic compositions for treating disease material, and methods of targeted therapy utilizing such compositions. These compositions comprise a) stable single domain magnetic particles; b) magnetic nanoparticles comprising aggregates of superparamagnetic grains; or c) magnetic nanoparticles comprising aggregates of stable single magnetic domain crystals and superparamagnetic grains. These compositions may also comprise a radio isotope, potential radioactive isotope, chemotherapeutic agent. These methods comprise the administration to a patient's body, body part, body fluid, or tissue of bioprobes (energy susceptive materials attached to a target-specific ligand), and the application of energy to the bioprobes so as to destroy, rupture, or inactivate the target in the patient. Energy forms, such as AMF, are utilized to provide the energy.Type: GrantFiled: November 1, 2005Date of Patent: June 8, 2010Assignee: Aduro BiotechInventor: Robert Ivkov
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Publication number: 20090317408Abstract: Magnetic nanoparticles exhibiting enhanced heating ability in thermotherapeutic applications are described, as are several strategies to conjugate such nanoparticles. Methods for using conjugated nanoparticles are also provided.Type: ApplicationFiled: December 15, 2008Publication date: December 24, 2009Applicant: Aduro BioTechInventors: Robert Ivkov, Cordula Gruttner, Knut Meuller, Joachim Teller, Fritz Westphal, Allan Foreman, David B. Kanne, Hsiao-Ling Chin, Paul C. Chinn
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Publication number: 20080213382Abstract: Untargeted magnetic nanoparticles exhibiting collective behavior and enhanced heating ability in thermotherapeutic applications are described, as are methods for using such untargeted magnetic nanoparticles.Type: ApplicationFiled: January 22, 2008Publication date: September 4, 2008Applicant: TRITON BIOSYSTEMS, INC.Inventors: Robert Ivkov, Allan Foreman
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Publication number: 20070112339Abstract: Disclosed are thermotherapeutic compositions for treating disease material, and methods of targeted therapy utilizing such compositions. These compositions comprise a) stable single domain magnetic particles; b) magnetic nanoparticles comprising aggregates of superparamagnetic grains; or c) magnetic nanoparticles comprising aggregates of stable single magnetic domain crystals and superparamagnetic grains. These compositions may also comprise a radio isotope, potential radioactive isotope, chemotherapeutic agent. These methods comprise the administration to a patient's body, body part, body fluid, or tissue of bioprobes (energy susceptive materials attached to a target-specific ligand), and the application of energy to the bioprobes so as to destroy, rupture, or inactivate the target in the patient. Energy forms, such as AMF, are utilized to provide the energy.Type: ApplicationFiled: November 1, 2005Publication date: May 17, 2007Inventor: Robert Ivkov
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Patent number: 7074175Abstract: Disclosed are compositions comprising magnetic nanoparticles, a biocompatible coating, and a target-specific ligand. Also disclosed are devices for treating diseased tissue for use with such compositions. Further disclosed are methods for treating diseased tissue, such as cancer, using such compositions and devices, as well as methods for treating diseased tissue utilizing hypertermia.Type: GrantFiled: June 18, 2002Date of Patent: July 11, 2006Inventors: Erik Schroeder Handy, Robert Ivkov, Diane Ellis-Busby, Allan Foreman
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Publication number: 20060142749Abstract: Disclosed are thermotherapeutic compositions for treating disease material, and methods of targeted therapy utilizing such compositions. These compositions comprise a) stable single domain magnetic particles; b) magnetic nanoparticles comprising aggregates of superparamagnetic grains; or c) magnetic nanoparticles comprising aggregates of stable single magnetic domain crystals and superparamagnetic grains. These compositions may also comprise a radio isotope, potential radioactive isotope, chemotherapeutic agent. These methods comprise the administration to a patient's body, body part, body fluid, or tissue of bioprobes (energy susceptive materials attached to a target-specific ligand), and the application of energy to the bioprobes so as to destroy, rupture, or inactivate the target in the patient. Energy forms, such as AMF, are utilized to provide the energy.Type: ApplicationFiled: November 1, 2005Publication date: June 29, 2006Inventor: Robert Ivkov
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Patent number: 6997863Abstract: Disclosed are therapeutic methods for the treatment of disease material involving administration of a thermotherapeutic magnetic composition, which contains single-domain magnetic particles attached to a target-specific ligand, to a patient and application of an alternating magnetic field to inductively heat the thermotherapeutic magnetic composition. Also disclosed are methods of administering the thermotherapeutic magnetic material composition. The thermotherapeutic methods may be used where the predetermined target is associated with diseases, such as cancer, diseases of the immune system, and pathogen-borne diseases, and undesirable targets, such as toxins, reactions associated with organ transplants, hormone-related diseases, and non-cancerous diseased cells or tissue.Type: GrantFiled: July 19, 2002Date of Patent: February 14, 2006Assignee: Triton BioSystems, Inc.Inventors: Erik S. Handy, Robert Ivkov, Diane Ellis-Busby, Allan Foreman, Susan J. Braunhut, Douglas U. Gwost, Blair Ardman
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Publication number: 20050271745Abstract: Disclosed are biocompatible magnetic nanoparticle compositions for various therapeutic or biological applications, and methods related thereto. Specifically, the present invention pertains to magnetic nanoparticle compositions prepared via high-pressure homogenization processes that include a turbulent flow zone. The methods of production may involve a two-step or a one-step process. The disclosed magnetic nanoparticle compositions may be useful in the treatment of the body, body part, tissue, cell, or body fluid of a subject for a variety of indications. The disclosed magnetic nanoparticle compositions may also be useful in the fixation, separation, transportation, marking or coding of targets, or energy transformation processes.Type: ApplicationFiled: July 9, 2004Publication date: December 8, 2005Inventors: Cordula Gruettner, Joachim Teller, Fritz Westphal, Robert Ivkov
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Publication number: 20050090732Abstract: Disclosed are compositions, systems and methods for treating a subject's body, body part, tissue, body fluid cells, pathogens, or other undesirable matter involving the administration of a targeted thermotherapy that comprises a bioprobe (energy susceptive materials that are attached to a target-specific ligand). Such targeted therapy methods can be combined with at least one other therapy technique. Other therapies include hyperthermia, direct antibody therapy, radiation, chemo- or pharmaceutical therapy, photodynamic therapy, surgical or interventional therapy, bone marrow or stem cell transplantation, and medical imaging, such as MRI, PET, SPECT, and bioimpedance.Type: ApplicationFiled: October 28, 2003Publication date: April 28, 2005Applicant: Triton Biosystems, Inc.Inventors: Robert Ivkov, Wolfgang Daum, Allan Foreman, Douglas Gwost
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Publication number: 20040156852Abstract: Methods for treating cells, diseased tissue, pathogens, or other undesirable matter involve the administration of a bioprobe (energy susceptive materials that are attached to a target-specific ligand) to a patient's body, body part, tissue, or body fluid (such as blood, blood plasma, or blood serum). An energy source provides energy to the bioprobe so as to destroy, rupture, or inactivate the target. Various energy forms, such as AMF, microwave, acoustic, or a combination thereof, created via a variety of mechanisms, may be used. The disclosed methods may be useful in the treatment of a variety of indications, including but not limited to, cancer of any type, such as bone marrow, lung, vascular, neuro, colon, ovarian, breast and prostate cancer, AIDS, adverse angiogenesis, restenosis, amyloidosis, tuberculosis, obesity, malaria, and illnesses due to viruses, such as HIV.Type: ApplicationFiled: February 6, 2003Publication date: August 12, 2004Applicant: Triton Biosystems, Inc.Inventors: Wolfgang Daum, Diane Ellis-Busby, Alan Foreman, Robert C. Goldstein, Douglas U. Gwost, Erik Schroeder Handy, Robert Ivkov, Valentin S. Nemkov
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Publication number: 20040156846Abstract: Methods for treating cells, diseased tissue, pathogens, or other undesirable matter involve the administration of a bioprobe (energy susceptive materials that are attached to the target-specific ligand chimeric L6 antibody) to a patient's body, body part, tissue, or body fluid (such as blood, blood plasma, or blood serum). An energy source provides energy to the bioprobe so as to destroy, rupture, or inactivate the target. Various energy forms, such as AMF, microwave, acoustic, or a combination thereof, created via a variety of mechanisms, may be used. The disclosed methods may be useful in the treatment of a variety of indications, including but not limited to, cancer of any type, such as bone marrow, lung, vascular, neuro, colon, ovarian, breast and prostate cancer.Type: ApplicationFiled: February 6, 2003Publication date: August 12, 2004Applicant: Triton Biosystems, Inc.Inventors: Wolfgang Daum, Gerald DeNardo, Diane Ellis-Busby, Alan Foreman, Douglas U. Gwost, Erik Schroeder Handy, Robert Ivkov
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Publication number: 20030032995Abstract: Disclosed are therapeutic methods for the treatment of disease material involving administration of a thermotherapeutic magnetic composition, which contains single-domain magnetic particles attached to a target-specific ligand, to a patient and application of an alternating magnetic field to inductively heat the thermotherapeutic magnetic composition. Also disclosed are methods of administering the thermotherapeutic magnetic material composition. The thermotherapeutic methods may be used where the predetermined target is associated with diseases, such as cancer, diseases of the immune system, and pathogen-borne diseases, and undesirable targets, such as toxins, reactions associated with organ transplants, hormone-related diseases, and non-cancerous diseased cells or tissue.Type: ApplicationFiled: July 19, 2002Publication date: February 13, 2003Applicant: Triton Biosystems, Inc.Inventors: Erik S. Handy, Robert Ivkov, Diane Ellis-Busby, Allan Foreman, Susan J. Braunhut, Douglas U. Gwost, Blair Ardman
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Publication number: 20030028071Abstract: Disclosed are compositions comprising magnetic nanoparticles, a biocompatible coating, and a target-specific ligand. Also disclosed are devices for treating diseased tissue for use with such compositions. Further disclosed are methods for treating diseased tissue, such as cancer, using such compositions and devices, as well as methods for treating diseased tissue utilizing hypertermia.Type: ApplicationFiled: June 18, 2002Publication date: February 6, 2003Applicant: Triton Biosystems, Inc.Inventors: Erik Schroeder Handy, Robert Ivkov, Diane Ellis-Busby, Allan Foreman