Patents by Inventor Robert J. Ardecky

Robert J. Ardecky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methionine sulfone and S-substituted cysteine sulfone derivatives as enzyme inhibitors
    Patent number: 5646165
    Abstract: This invention relates to compounds which inhibit thrombin or factor Xa. The compounds contain an aldehyde functionality and a methionine sulfone or S-substituted cysteine sulfone residue. The compounds and their pharmaceutical compositions are useful for preventing thrombosis in mammals which are suspected of having a condition characterized by abnormal thrombosis.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: July 8, 1997
    Assignee: Corvas International, Inc.
    Inventors: Matthew M. Abelman, Robert J. Ardecky, Ruth F. Nutt
  • Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists
    Patent number: 5310929
    Abstract: Prodrugs of imidazole carboxylic acids which are AII antagonists useful in treating hypertension, pharmaceutical compositions thereof and a method of treating hypertension using such prodrugs are disclosed.
    Type: Grant
    Filed: August 6, 1992
    Date of Patent: May 10, 1994
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Robert J. Ardecky, Carol L. Ensinger, James R. Pruitt
  • Fused aryl substituted imidazole angiotensin II receptor inhibitors
    Patent number: 5254546
    Abstract: Substituted imidazoles such as ##STR1## which are useful as angiotensin II receptor inhibitors. These compounds have activity in treating hypertension and congestive heart failure.
    Type: Grant
    Filed: June 18, 1992
    Date of Patent: October 19, 1993
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Robert J. Ardecky, David J. Carini, John Jonas V. Duncia, Pancras C. Wong
  • Treatment of CNS disorders with 4,5,6,7-tetrahydro-1H-imidazo (4,5-)-pyridines and analogs
    Patent number: 5091390
    Abstract: Provided are 4,5,6,7-tetrahydro-1H-imidazo(4,5-c)-pyridine derivatives, methods for preparing them, pharmaceutical compositions containing them, and methods of using them to treat disorders of mammals mediated by AII type-2 receptors in the central nervous system.
    Type: Grant
    Filed: September 20, 1990
    Date of Patent: February 25, 1992
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Robert J. Ardecky, Andrew T. Chiu, John J. V. Duncia, Petrus B. M. W. M. Timmermans, Ruth R. Wexler
  • Bis-naphthalimides as anticancer agents
    Patent number: 5086059
    Abstract: There are provided novel bis-napthalimide compounds useful as antitumor agents, pharmaceutical compositions containing them and processes for preparing intermediates to such compounds.
    Type: Grant
    Filed: June 7, 1990
    Date of Patent: February 4, 1992
    Assignee: Du Pont Merck Pharmaceutical Company
    Inventors: Robert J. Ardecky, Arthur D. Patten, Jung-Hui Sun