Patents by Inventor Robert J. Bayer

Robert J. Bayer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Glycopegylated erythropoietin
    Publication number: 20080305992
    Abstract: The present invention provides conjugates between erythropoietin and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.
    Type: Application
    Filed: October 31, 2007
    Publication date: December 11, 2008
    Applicant: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, Robert J. Bayer, David A. Zopf
  • Glycopegylated erythropoietin
    Publication number: 20080300175
    Abstract: The present invention provides conjugates between erythropoietin and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.
    Type: Application
    Filed: October 31, 2007
    Publication date: December 4, 2008
    Applicant: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, Robert J. Bayer, David A. Zopf
  • Glycopegylated Factor Ix
    Publication number: 20080255026
    Abstract: The present invention provides conjugates between Factor Ix and PEG moieties. The conjugates are linked via a glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. Conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.
    Type: Application
    Filed: May 25, 2006
    Publication date: October 16, 2008
    Inventors: Shawn DeFrees, Robert J. Bayer, Caryn Bowe, Panneerselvam Krishnasamy
  • Pharmaceutical compositions of glycoconjugates
    Patent number: 7416858
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group of peptide.
    Type: Grant
    Filed: October 9, 2002
    Date of Patent: August 26, 2008
    Assignee: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David A. Zopf, Robert J. Bayer, Caryn Bowe, David James Hakes, Xi Chen
  • Erythropoietin: remodeling and glycoconjugation of erythropoietin
    Publication number: 20080187955
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Application
    Filed: February 2, 2007
    Publication date: August 7, 2008
    Applicant: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David A. Zopf, Robert J. Bayer, Caryn Bowe, David James Hakes, Xi Chen
  • Glycopegylated erythropoietin
    Patent number: 7405198
    Abstract: The present invention provides conjugates between erythropoietin and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.
    Type: Grant
    Filed: November 24, 2004
    Date of Patent: July 29, 2008
    Assignee: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, Robert J. Bayer, David A. Zopf
  • Glycoconjugation methods and proteins/peptides produced by the methods
    Publication number: 20080146494
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Application
    Filed: March 5, 2007
    Publication date: June 19, 2008
    Applicant: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David A. Zopf, Robert J. Bayer, Caryn Bowe, David James Hakes, Xi Chen
  • Glycopegylated Follicle Stimulating Hormone
    Publication number: 20080015142
    Abstract: The present invention provides conjugates between follicle stimulating hormone and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.
    Type: Application
    Filed: December 3, 2004
    Publication date: January 17, 2008
    Inventors: Shawn DeFrees, Robert J. Bayer, Caryn Bowe
  • Glycopegylation methods and proteins/peptides produced by the methods
    Patent number: 7265084
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Grant
    Filed: April 9, 2003
    Date of Patent: September 4, 2007
    Assignee: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David A. Zopf, Robert J. Bayer, Caryn Bowe, David James Hakes, Xi Chen
  • Practical sialylation of recombinant glycoproteins
    Patent number: 7220555
    Abstract: This invention provides methods for practical in vitro sialylation of glycoproteins, including recombinantly produced glycoproteins. The methods are useful for large-scale modification of sialylation patterns.
    Type: Grant
    Filed: February 21, 2002
    Date of Patent: May 22, 2007
    Assignee: Neose Technologies, Inc.
    Inventors: James C. Paulson, Robert J. Bayer, Eric Sjoberg
  • Erythropoietin: remodeling and glycoconjugation of erythropoietin
    Patent number: 7214660
    Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
    Type: Grant
    Filed: April 9, 2003
    Date of Patent: May 8, 2007
    Assignee: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, David A. Zopf, Robert J. Bayer, Caryn Bowe, David James Hakes, Xi Chen
  • In vitro modification of glycosylation patterns of recombinant glycopeptides
    Publication number: 20030180835
    Abstract: This invention provides methods for modifying glycosylation patterns of glycopeptides, including recombinantly produced glycopeptides. Also provided are glycopeptide compositions in which the glycopeptides have a uniform glycosylation pattern.
    Type: Application
    Filed: March 17, 2003
    Publication date: September 25, 2003
    Applicant: Neose Technologies, Inc.
    Inventor: Robert J. Bayer
  • Practical in vitro sialylation of recombinant glycoproteins
    Publication number: 20030124645
    Abstract: This invention provides methods for practical in vitro sialylation of glycoproteins, including recombinantly produced glycoproteins. The methods are useful for large-scale modification of sialylation patterns.
    Type: Application
    Filed: August 13, 2002
    Publication date: July 3, 2003
    Applicant: Neose Technologies, Inc.
    Inventors: James C. Paulson, Robert J. Bayer, Eric Sjoberg
  • In vitro modification of glycosylation patterns of recombinant glycopeptides
    Publication number: 20030040037
    Abstract: This invention provides methods for modifying glycosylation patterns of glycopeptides, including recombinantly produced glycopeptides. Also provided are glycopeptide compositions in which the glycopeptides have a uniform glycosylation pattern.
    Type: Application
    Filed: August 13, 2002
    Publication date: February 27, 2003
    Applicant: Neose Technologies, Inc.
    Inventor: Robert J. Bayer
  • Vitro modification of glycosylation patterns of recombinant glycopeptides
    Publication number: 20030003529
    Abstract: This invention provides methods for modifying glycosylation patterns of glycopeptides, including recombinantly produced glycopeptides. Also provided are glycopeptide compositions in which the glycopeptides have a uniform glycosylation pattern.
    Type: Application
    Filed: July 19, 2002
    Publication date: January 2, 2003
    Applicant: Neose Technologies, Inc.
    Inventor: Robert J. Bayer
  • Practical in vitro sialylation of recombinant glycoproteins
    Publication number: 20020160460
    Abstract: This invention provides methods for practical in vitro sialylation of glycoproteins, including recombinantly produced glycoproteins. The methods are useful for large-scale modification of sialylation patterns.
    Type: Application
    Filed: February 21, 2002
    Publication date: October 31, 2002
    Applicant: Neose Technologies, Inc.
    Inventors: James C. Paulson, Robert J. Bayer, Eric Sjoberg
  • Practical in vitro sialylation of recombinant glycoproteins
    Publication number: 20020142370
    Abstract: This invention provides methods for practical in vitro sialylation of glycoproteins, including recombinantly produced glycoproteins. The methods are useful for large-scale modification of sialylation patterns.
    Type: Application
    Filed: February 21, 2002
    Publication date: October 3, 2002
    Applicant: Neose Technologies, Inc.
    Inventors: James C. Paulson, Robert J. Bayer, Eric Sjoberg
  • Practical in vitro sialylation of recombinant glycoproteins
    Publication number: 20020119516
    Abstract: This invention provides methods for practical in vitro sialylation of glycoproteins, including recombinantly produced glycoproteins. The methods are useful for large-scale modification of sialylation patterns.
    Type: Application
    Filed: November 9, 2001
    Publication date: August 29, 2002
    Applicant: Cytel Corporation
    Inventors: James C. Paulson, Robert J. Bayer, Eric Sjoberg
  • Practical in vitro sialylation of recombinant glycoproteins
    Patent number: 6399336
    Abstract: This invention provides methods for practical in vitro sialylation of glycoproteins, including recombinantly produced glycoproteins. The methods are useful for large-scale modification of sialylation patterns.
    Type: Grant
    Filed: January 15, 1998
    Date of Patent: June 4, 2002
    Assignee: Neose Technologies, Inc.
    Inventors: James C. Paulson, Robert J. Bayer, Eric Sjoberg
  • Enzymatic synthesis of oligosaccharides
    Patent number: 6030815
    Abstract: The present invention provides improved methods for the preparation of sialyl galactosides. The methods use sialyl transferase cycle in which the reaction conditions are optimized to provide increased yields.
    Type: Grant
    Filed: April 10, 1996
    Date of Patent: February 29, 2000
    Assignee: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, Robert J. Bayer, Murray Ratcliffe