Patents by Inventor Robert J. Collier

Robert J. Collier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Variant LovD polypeptides and their uses
    Patent number: 11926857
    Abstract: The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound.
    Type: Grant
    Filed: May 25, 2021
    Date of Patent: March 12, 2024
    Assignee: Codexis, Inc.
    Inventors: Lynne Gilson, Steven J. Collier, Joly Sukumaran, Wan Lin Yeo, Oscar Alvizo, Ee Ling Teo, Robert J. Wilson, Junye Xu
  • CONTROL OF MILK PRODUCTION AND MAMMARY INVOLUTION
    Publication number: 20150196507
    Abstract: The present invention is a method for increasing serotonin activity in mammary glands such that involution of milk secretion of the same mammary glands occurs. The present invention further is a composition that can be implanted, or infused into the mammary glands to cause involution of milk secretion.
    Type: Application
    Filed: January 14, 2015
    Publication date: July 16, 2015
    Inventors: Nelson D. Horseman, Robert J. Collier, Aaron M. Marshall, Laura Hernandez Baumgard
  • Method for delivering agents into cells using bacterial toxins
    Patent number: 9079952
    Abstract: The invention provides compositions and methods for delivering a bioactive moiety comprising at least one non-natural component into a cell cytosol of an eukaryotic cell. The bioactive moiety is linked to an A component of a bacterial toxin, a functional wild-type or modified fragment thereof, or an A component surrogate or mimetic. For delivery, the cell is contacted with the linked bioactive moiety and a corresponding B component of the bacterial toxin or a functional fragment thereof.
    Type: Grant
    Filed: January 10, 2012
    Date of Patent: July 14, 2015
    Assignee: President and Fellows of Harvard College
    Inventors: Robert J. Collier, Brad L. Pentelute
  • Control of milk production and mammary involution
    Patent number: 8987336
    Abstract: The present invention is a method for increasing serotonin activity in mammary glands such that involution of milk secretion of the same mammary glands occurs. The present invention further is a composition that can be implanted, or infused into the mammary glands to cause involution of milk secretion.
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: March 24, 2015
    Assignee: Amelgo, LLC
    Inventors: Nelson D. Horseman, Robert J. Collier, Aaron M. Marshall, Laura Hernandez Baumgard
  • Biodegradable Iron Oxide Nanoparticle Gel for Tumor Bed Therapy
    Publication number: 20140219926
    Abstract: A biodegradable iron oxide nanoparticle gel for hyperthermia treatment of cancer includes a polysaccharide-based carrier matrix and starch-coated iron oxide nanoparticles. The gel has sufficient deformability to integrate into a diffuse tumor site, adheres to tissue and has sufficient mechanical properties to remain in place during hyperthermia treatment. The gel releases iron oxide nanoparticles for uptake by cancerous cells at the tumor margin.
    Type: Application
    Filed: February 3, 2014
    Publication date: August 7, 2014
    Applicant: The Trustees Of Dartmouth College
    Inventors: Benjamin P. Cunkelman, Jennifer A. Tate, Alicia A. Petryk, P. Jack Hoopes, Robert J. Collier, Sara G. Thappa
  • Use of beta-adrenoceptor antagonists for the manufacture of a medicament of the treatment of disorders of the outer retina
    Patent number: 8710102
    Abstract: Compositions and methods for treating disorders of the outer retina with ?-adrenoceptor antagonists are disclosed.
    Type: Grant
    Filed: June 9, 2010
    Date of Patent: April 29, 2014
    Assignee: Novartis AG
    Inventors: Robert J. Collier, Jr., Michael A. Kapin, Louis DeSantis, Jr.
  • METHOD FOR DELIVERING AGENTS INTO CELLS USING BACTERIAL TOXINS
    Publication number: 20130336974
    Abstract: The invention provides compositions and methods for delivering a bioactive moiety comprising at least one non-natural component into a cell cytosol of an eukaryotic cell. The bioactive moiety is linked to an A component of a bacterial toxin, a functional wild-type or modified fragment thereof, or an A component surrogate or mimetic. For delivery, the cell is contacted with the linked bioactive moiety and a corresponding B component of the bacterial toxin or a functional fragment thereof.
    Type: Application
    Filed: January 10, 2012
    Publication date: December 19, 2013
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Robert J. Collier, Brad L. Pentelute
  • Use of cyclodextrins as an active ingredient for treating dry AMD and solubilizing drusen
    Patent number: 8158609
    Abstract: The present invention is directed to the treatment of disorders involving the accumulation of drusen, such as dry age-related macular degeneration and geographic atrophy via administration of therapeutically effective amounts of at least one monomeric or polymeric cyclodextrin.
    Type: Grant
    Filed: November 2, 2007
    Date of Patent: April 17, 2012
    Assignee: Novartis AG
    Inventors: David Allen Marsh, Robert J. Collier, Jr., Michael A. Kapin, Youqin Tian, Eliot Mark Slovin
  • Control of milk production and mammary involution
    Patent number: 8133916
    Abstract: The present invention is a method for increasing serotonin activity in mammary glands such that involution of milk secretion of the same mammary glands occurs. The present invention further is a composition that can be implanted, or infused into the mammary glands to cause involution of milk secretion.
    Type: Grant
    Filed: March 10, 2010
    Date of Patent: March 13, 2012
    Assignee: Amelgo, LLC
    Inventors: Nelson D. Horseman, Robert J. Collier, Aaron M. Marshall, Laura Hernandez Baumgard
  • Superoxide dismutase mimics for the treatment of ocular disorders and diseases
    Patent number: 8067405
    Abstract: The use of SOD mimics, particularly Mn(III) salen SOD mimics, for the treatment of AMD, DR, and retinal edema is disclosed.
    Type: Grant
    Filed: March 24, 2010
    Date of Patent: November 29, 2011
    Assignee: Novartis AG
    Inventors: Peter G. Klimko, Robert J. Collier, Jr., Mark R. Hellberg
  • Superoxide dismutase mimics for the treatment of ocular disorders and diseases
    Patent number: 8003635
    Abstract: The use of SOD mimics particularly pentaazacycle Mn(II) complex SOD mimics, for the treatment of AMD, DR, and retinal edema is disclosed.
    Type: Grant
    Filed: April 23, 2010
    Date of Patent: August 23, 2011
    Assignee: Novartis AG
    Inventors: Peter G. Klimko, Robert J. Collier, Jr., Mark R. Hellberg
  • Use of Monoamine Oxidase Inhibitors to Treat Outer Retina Disorders
    Publication number: 20110160308
    Abstract: Compositions and methods for treating disorders of the outer retina with compounds that inhibit monoamine oxidase are disclosed.
    Type: Application
    Filed: July 27, 2007
    Publication date: June 30, 2011
    Applicant: ALCON RESEARCH, LTD.
    Inventors: Robert J. Collier, JR., Michael A. Kapin, John M. Yanni
  • Use of Beta-Adrenoceptor Antagonists for the Manufacture of a Medicament for the Treatment of Disorders of the Outer Retina
    Publication number: 20100249134
    Abstract: Compositions and methods for treating disorders of the outer retina with ?-adrenoceptor antagonists are disclosed.
    Type: Application
    Filed: June 9, 2010
    Publication date: September 30, 2010
    Applicant: ALCON, INC.
    Inventors: Robert J. Collier, Jr., Louis DeSantis, JR., Michael A. Kapin
  • SUPEROXIDE DISMUTASE MIMICS FOR THE TREATMENT OF OCULAR DISORDERS AND DISEASES
    Publication number: 20100204194
    Abstract: The use of SOD mimics particularly pentaazacycle Mn(II) complex SOD mimics, for the treatment of AMD, DR, and retinal edema is disclosed.
    Type: Application
    Filed: April 23, 2010
    Publication date: August 12, 2010
    Applicant: ALCON, INC.
    Inventors: Peter G. Klimko, Robert J. Collier, JR., Mark R. Hellberg
  • Compounds with 5-HTactivity useful for treating disorders of the outer retina
    Patent number: 7763619
    Abstract: Compositions and methods for treating disorders of the outer retina with compounds with 5-HT1A agonist activity are disclosed.
    Type: Grant
    Filed: July 22, 2005
    Date of Patent: July 27, 2010
    Assignee: Alcon, Inc.
    Inventors: Robert J. Collier, Jr., Michael A. Kapin, Mark R. Hellberg, Thomas R. Dean
  • Superoxide dismutase mimics for the treatment of ocular disorders and diseases
    Patent number: 7759333
    Abstract: The use of SOD mimics particularly pentaazacycle Mn(II) complex SOD mimics, for the treatment of AMD, DR, and retinal edema is disclosed.
    Type: Grant
    Filed: December 6, 2002
    Date of Patent: July 20, 2010
    Assignee: Alcon, Inc.
    Inventors: Peter G. Klimko, Robert J. Collier, Jr., Mark R. Hellberg
  • SUPEROXIDE DISMUTASE MIMICS FOR THE TREATMENT OF OCULAR DISORDERS AND DISEASES
    Publication number: 20100179117
    Abstract: The use of SOD mimics, particularly Mn(III) salen SOD mimics, for the treatment of AMD, DR, and retinal edema is disclosed.
    Type: Application
    Filed: March 24, 2010
    Publication date: July 15, 2010
    Applicant: ALCON, INC.
    Inventors: Peter G. Klimko, Robert J. Collier, JR., Mark R. Hellberg
  • Superoxide dismutase mimics for the treatment of ocular disorders and diseases
    Patent number: 7754706
    Abstract: The use of SOD mimics, particularly Mn(III) salen SOD mimics, for the treatment of AMD, DR, and retinal edema is disclosed.
    Type: Grant
    Filed: December 5, 2003
    Date of Patent: July 13, 2010
    Assignee: Alcon, Inc.
    Inventors: Peter G. Klimko, Robert J. Collier, Jr., Mark R. Hellberg
  • COMPOUNDS WITH 5-HT1A ACTIVITY USEFUL FOR TREATING DISORDERS OF THE OUTER RETINA
    Publication number: 20100168121
    Abstract: Compositions and methods for treating disorders of the outer retina with compounds with 5-HT1A agonist activity are disclosed.
    Type: Application
    Filed: March 8, 2010
    Publication date: July 1, 2010
    Applicant: ALCON, INC.
    Inventors: Robert J. Collier, JR., Michael A. Kapin, Mark R. Hellberg, Thomas R. Dean
  • METHODS FOR TREATING MACULAR EDEMA AND PATHOLOGIC OCULAR ANGIOGENESIS USING A NEUROPROTECTIVE AGENT AND A RECEPTOR TYROSINE KINASE INHIBITOR
    Publication number: 20080153819
    Abstract: The present invention provides methods for inhibiting increased vascular permeability and/or pathologic ocular angiogenesis and providing neuroprotection of the affected retina via administration of a combination of one or more molecules that potently inhibit select receptor tyrosine kinases (RTKs) or vascular endothelial growth factor (VEGF) and one or more neuroprotectants.
    Type: Application
    Filed: December 21, 2007
    Publication date: June 26, 2008
    Inventors: David P. Bingaman, Robert J. Collier, Robert A. Landers, Kristina L. Rhoades