Patents by Inventor Robert J. Dinerstein

Robert J. Dinerstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INTERLEUKIN-4 GENE EXPRESSION INHIBITORS
    Publication number: 20080132481
    Abstract: This invention discloses and claims a class of indole and benzo(b)thiophene derivatives for use in treating allergy, asthma, rhinitis, dermatitis, B-cell lymphomas, tumors and diseases associated with bacterial, rhinovirus or respiratory syncytial virus (RSV) infections. The compounds of this invention are defined by the Formula (I): wherein X, Y, Z, R1, R2 and R3 are as defined in the specification; or a pharmaceutically acceptable salt thereof. In preferred embodiments of this invention it is also disclosed and claimed that the compounds of this invention are capable of modulating T helper (Th) cells, Th1/Th2, and thereby capable of inhibiting the transcription of interleukin-4 (IL-4) message, IL-4 release or IL-4 production.
    Type: Application
    Filed: November 30, 2007
    Publication date: June 5, 2008
    Inventors: Sefik S. ALKAN, Robert J. DINERSTEIN, Nicholas J. HRIB, Arun SUBRAMANIAM, John G. JURCAK
  • Interleukin-4 gene expression inhibitors
    Publication number: 20040006123
    Abstract: This invention discloses and claims a class of indole and benzo(b)thiophene derivatives for use in treating allergy, asthma, rhinitis, dermatitis, B-cell lymphomas, tumors and diseases associated with bacterial, rhinovirus or respiratory syncytial virus (RSV) infections.
    Type: Application
    Filed: April 23, 2003
    Publication date: January 8, 2004
    Inventors: Sefik S. Alkan, Robert J. Dinerstein, Nicholas J. Hrib, Arun Subramaniam, John G. Jurcak
  • Alkyloxyamino substituted fluorenones and their use as protein kinase-C inhibitors
    Patent number: 6004959
    Abstract: The present invention describes certain alkyloxyamino-substituted fluorenones which inhibit protein kinase C, as well as pharmaceutical compositions including these compounds and methods of using these compounds to control protein kinase C activity in mammals, including humans. More specifically, the present compounds are useful for the treatment of neoplastic disease states, disorders associated with abnormal blood flow (including hypertension, ischemia, atherosclerosis, coagulation disorders), and inflammatory diseases (including immune disorders, asthma, lung fibrosis, and psoriasis).
    Type: Grant
    Filed: April 18, 1997
    Date of Patent: December 21, 1999
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Winton D. Jones, Fred L. Ciske, Robert J. Dinerstein, Keith A. Diekema
  • Calcium uptake inhibitors
    Patent number: 5500429
    Abstract: This invention relates to 1-aryl-3-pyridinyl-2-propene-1-ones, the use of these compounds as calcium uptake inhibitors in leukocytes and thrombocytes, and pharmaceutical compositions containing these compounds as active ingredients, and the process of their preparation.
    Type: Grant
    Filed: November 17, 1993
    Date of Patent: March 19, 1996
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Robert J. Dinerstein, Michael L. Edwards, David M. Stemerick, Keith A. Diekema
  • 1-phenyl-3-phenyl-2-propyne-1-ones as calcium uptake inhibitors
    Patent number: 5446068
    Abstract: This invention relates to 1-phenyl-3-phenyl-2-propyne-1-ones, the use of these compounds as calcium uptake inhibitors in leukocytes and thrombocytes, and pharmaceutical compositions containing these compounds as active ingredients, and the process of their preparation.
    Type: Grant
    Filed: September 16, 1994
    Date of Patent: August 29, 1995
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Robert J. Dinerstein, Jeffrey S. Sabol, Keith A. Diekema
  • Calcium uptake inhibitors
    Patent number: 5409942
    Abstract: This invention relates to 1-phenyl-3-aryl-2-propyne-1-ones, the use of these compounds as calcium uptake inhibitors in leukocytes and thrombocytes, and pharmaceutical compositions containing these compounds as active ingredients, and the process of their preparation.
    Type: Grant
    Filed: March 5, 1993
    Date of Patent: April 25, 1995
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Robert J. Dinerstein, Jeffrey S. Sabol, Keith A. Diekema
  • Calcium uptake inhibitors
    Patent number: 5248825
    Abstract: This invention relates to 1-phenyl-3-phenyl-2-propyne-1-ones, the use of these compounds as calcium uptake inhibitors in leukocytes and thrombocytes, and pharmaceutical compositions containing these compounds as active ingredients, and the process of their preparation.
    Type: Grant
    Filed: June 1, 1992
    Date of Patent: September 28, 1993
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Robert J. Dinerstein, Jeffrey S. Sabol, Keith A. Diekema
  • 1-phenyl-3-aryl-2-propyne-1-one useful as calcium uptake inhibitors
    Patent number: 5223518
    Abstract: This invention relates to 1-phenyl-3-aryl-2-propyne-1-ones, the use of these compounds as calcium uptake inhibitors in leukocytes and thrombocytes, and pharmaceutical compositions containing these compounds as active ingredients, and the process of their preparation.
    Type: Grant
    Filed: June 1, 1992
    Date of Patent: June 29, 1993
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Robert J. Dinerstein, Jeffrey S. Sabol, Keith A. Diekema