Abstract: Disclosed are receptor cytokine switches, immune cells containing them, and uses thereof for controllable adoptive cell therapy.

Abstract: The present invention provides universal immunotherapy compositions useful for targeted treatment of cancers. The present invention utilizes in its various aspects, bifunctional compounds or complexes that contain at least two domains. One domain, referred to herein as a targeting moiety, binds an antigen on the surface of a tumor cell. The other domain, referred to herein as a pro-antigen, is designed to be inert to normal (non-diseased) cells and tissues, and to become activated (or “unmasked” or “uncaged”) only upon exposure to light of an appropriate wavelength.

Abstract: Disclosed are compositions and methods for treating cancers characterized by the presence of solid tumors, which simultaneously target a plurality of targets on cancer cells using single CAR T construct.

Abstract: The present invention provides universal immunotherapy compositions useful for targeted treatment of cancers. The present invention utilizes in its various aspects, bifunctional compounds or complexes that contain at least two domains. One domain, referred to herein as a targeting moiety, binds an antigen on the surface of a tumor cell. The other domain, referred to herein as a pro-antigen, is designed to be inert to normal (non-diseased) cells and tissues, and to become activated (or “unmasked” or “unaged”) only upon exposure to light of an appropriate wavelength.

Abstract: Systems, methods, and apparatus are disclosed for recovering one or more target cells from a fluid sample. A first chamber aligned with a first surface of a removable filter receives the fluid sample. The removable filter defines a plurality of pores configured to retain the one or more target cells on the first surface and/or in the plurality of pores, each pore of the plurality of pores having a first diameter smaller than a diameter of the one or more target cells in the first surface and a second diameter greater than the first diameter in a second surface of the removable filter. A second chamber comprises a hydrophilic microporous wick structure configured to contact the second surface of the removable filter and capillarize any non-target cells and fluid from the fluid sample, drawing them into the second chamber.

Abstract: Systems, methods, and apparatus are disclosed for recovering one or more target cells from a fluid sample. A first chamber aligned with a first surface of a removable filter receives the fluid sample. The removable filter defines a plurality of pores configured to retain the one or more target cells on the first surface and/or in the plurality of pores, each pore of the plurality of pores having a first diameter smaller than a diameter of the one or more target cells in the first surface and a second diameter greater than the first diameter in a second surface of the removable filter. A second chamber comprises a hydrophilic microporous wick structure configured to contact the second surface of the removable filter and capillarize any non-target cells and fluid from the fluid sample, drawing them into the second chamber.

Abstract: Methods and materials for increasing the number of target cells recovered from a fluid sample containing cells are described. The methods include isolating the target cells on a filter and then implanting the filter containing the target cells in an immunodeficient non-human animal, where at least some of the target cells can proliferate.