Patents by Inventor Robert J. Drummond

Robert J. Drummond has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for increasing the serum half-life of a biologically active molecule
    Patent number: 7022673
    Abstract: A method is provided for preparing a biologically active molecule having an increased serum half-life. The method involves conjugating a polymer such as polyethylene glycol to the biologically active molecule. Also provided are polypeptide drugs having an increased serum half-life, e.g., human urokinase plasminogen activator (human “uPA” or “hUPA”) or a fragment or derivative thereof. Pharmaceutical compositions containing such molecules and methods of using them to treat uPA-mediated and uPA receptor-mediated disorders are also provided.
    Type: Grant
    Filed: April 11, 2002
    Date of Patent: April 4, 2006
    Assignee: Chiron Corporation
    Inventors: Robert J. Drummond, Steve Rosenberg
  • Method for increasing the serum half-life of a biologically active molecule
    Publication number: 20020182705
    Abstract: A method is provided for preparing a biologically active molecule having an increased serum half-life. The method involves conjugating a polymer such as polyethylene glycol to the biologically active molecule. Also provided are polypeptide drugs having an increased serum half-life, e.g., human urokinase plasminogen activator (human “uPA” or “hUPA”) or a fragment or derivative thereof. Pharmaceutical compositions containing such molecules and methods of using them to treat uPA-mediated and uPA receptor-mediated disorders are also provided.
    Type: Application
    Filed: April 11, 2002
    Publication date: December 5, 2002
    Inventors: Robert J. Drummond, Steve Rosenberg
  • Method for increasing the serum half-life of a biologically active molecule
    Patent number: 6423685
    Abstract: A method is provided for preparing a biologically active molecule having an increased serum half-life. The method involves conjugating a polymer such as polyethylene glycol to the biologically active molecule. Also provided are polypeptide drugs having an increased serum half-life, e.g., human urokinase plasminogen activator (human “uPA” or “hUPA”) or a fragment or derivative thereof. Pharmaceutical compositions containing such molecules and methods of using them to treat uPA-mediated and uPA receptor-mediated disorders are also provided.
    Type: Grant
    Filed: March 5, 1999
    Date of Patent: July 23, 2002
    Assignee: Chiron Corporation
    Inventors: Robert J. Drummond, Steve Rosenberg
  • Procaryotic xylose isomerase muteins
    Patent number: 5041378
    Abstract: Xylose isomerase (XI) muteins useful in the conversion of glucose to fructose or xylose to xylulose are obtained in usable amounts by protein structural and recombinant DNA methods, including x-ray crystallography, cloning, computer graphic modeling and site-directed mutagenesis and expression of the bacterial DNA sequences encoding native procaryotic xylose isomerase. These native sequences are altered to encode the xylose isomerase muteins having improved catalytic function and/or thermostability.
    Type: Grant
    Filed: August 11, 1987
    Date of Patent: August 20, 1991
    Assignees: Cetus Corporation, Univerity of Oregon
    Inventors: Robert J. Drummond, Will Bloch, Brian W. Matthews, Pamela L. Toy