Abstract: A micro electro mechanical system is provided. The micro electro mechanical system includes a first part bonded to a second part by a structural adhesive interface. The structural adhesive interface includes a conductive structural adhesive portion, and a non-conductive structural adhesive portion at least partially surrounding the conductive structural adhesive portion. The conductive structural adhesive portion and the non-conductive structural adhesive portion have a thixotropy index greater than one.

Abstract: An active injection guide concurrently monitors surface contact and an instantaneous contact force along an injection axis of an injector in order to ensure that the injector is properly positioned on a patient before an injection can be initiated.

Abstract: An apparatus for transdermal injection includes a collet configured to transition between first and second states. In the first state, the collet receives a cartridge with a predetermined elongate shape. In the second state, an inner surface of the collet substantially conforms to the predetermined elongate shape of the cartridge such that expansion of the cartridge, when the cartridge is pressurized, is substantially uniformly opposed.

Abstract: An apparatus for injectate delivery includes a cartridge, a linear actuator, a rotary motor mechanically coupled the actuator, and a controller coupled to the motor. The controller controls a linear motion of the actuator by controlling an electrical input supplied to the motor in a first interval during which the motor is stationary with the linear actuator engaged with the cartridge to displace an injectate in the cartridge, a second interval following the first interval during which the controller accelerates the motor from stationary to a first speed selected to create a jet of the injectate from the cartridge with a velocity sufficient to pierce human tissue to a subcutaneous depth, a third interval during which the controller maintains the motor at or above the first speed, and a fourth interval during which the controller decelerates the motor to a second speed to deliver the injectate at the subcutaneous depth.

Abstract: An apparatus for injectate delivery includes a cartridge, a linear actuator, a rotary motor mechanically coupled the actuator, and a controller coupled to the motor. The controller controls a linear motion of the actuator by controlling an electrical input supplied to the motor in a first interval during which the motor is stationary with the linear actuator engaged with the cartridge to displace an injectate in the cartridge, a second interval following the first interval during which the controller accelerates the motor from stationary to a first speed selected to create a jet of the injectate from the cartridge with a velocity sufficient to pierce human tissue to a subcutaneous depth, a third interval during which the controller maintains the motor at or above the first speed, and a fourth interval during which the controller decelerates the motor to a second speed to deliver the injectate at the subcutaneous depth.

Abstract: An apparatus for injectate delivery includes a cartridge, a linear actuator, a rotary motor mechanically coupled the actuator, and a controller coupled to the motor. The controller controls a linear motion of the actuator by controlling an electrical input supplied to the motor in a first interval during which the motor is stationary with the linear actuator engaged with the cartridge to displace an injectate in the cartridge, a second interval following the first interval during which the controller accelerates the motor from stationary to a first speed selected to create a jet of the injectate from the cartridge with a velocity sufficient to pierce human tissue to a subcutaneous depth, a third interval during which the controller maintains the motor at or above the first speed, and a fourth interval during which the controller decelerates the motor to a second speed to deliver the injectate at the subcutaneous depth.

Abstract: An injection device for use with a cartridge containing an injectate includes a housing. The housing includes an end wall at its distal end and an inner wall. The inner wall extends in a direction from the proximal end of the housing to the distal end of the housing and separates a first chamber from a second chamber in the housing. The housing includes a first opening disposed in the end wall and is in fluid communication with the first chamber. The housing includes a second opening is in fluid communication with the second chamber. A coupler is disposed in the first chamber for coupling to the cartridge. The first opening and the second opening are in fluid communication via a channel for transfer of fluid between the first chamber and the second chamber.

Abstract: An active injection guide concurrently monitors surface contact and an instantaneous contact force along an injection axis of an injector in order to ensure that the injector is properly positioned on a patient before an injection can be initiated.

Abstract: An apparatus for injectate delivery includes a cartridge, a linear actuator, a rotary motor mechanically coupled the actuator, and a controller coupled to the motor. The controller controls a linear motion of the actuator by controlling an electrical input supplied to the motor in a first interval during which the motor is stationary with the linear actuator engaged with the cartridge to displace an injectate in the cartridge, a second interval following the first interval during which the controller accelerates the motor from stationary to a first speed selected to create a jet of the injectate from the cartridge with a velocity sufficient to pierce human tissue to a subcutaneous depth, a third interval during which the controller maintains the motor at or above the first speed, and a fourth interval during which the controller decelerates the motor to a second speed to deliver the injectate at the subcutaneous depth.

Abstract: An injector cartridge is configured for sterile storage and transfer of a fluid in a pre-filled syringe. The injector cartridge includes a first housing section and a second housing section and is configured to move the pre-filled syringe from a sterile storage position to a fluid transfer position upon linear displacement of the first housing section relative to the second housing section.

Abstract: An apparatus for injectate delivery includes a cartridge, a linear actuator, a rotary motor mechanically coupled the actuator, and a controller coupled to the motor. The controller controls a linear motion of the actuator by controlling an electrical input supplied to the motor in a first interval during which the motor is stationary with the linear actuator engaged with the cartridge to displace an injectate in the cartridge, a second interval following the first interval during which the controller accelerates the motor from stationary to a first speed selected to create a jet of the injectate from the cartridge with a velocity sufficient to pierce human tissue to a subcutaneous depth, a third interval during which the controller maintains the motor at or above the first speed, and a fourth interval during which the controller decelerates the motor to a second speed to deliver the injectate at the subcutaneous depth.

Abstract: A compliance tracking device includes a receiver configured to receive a signal from at least one sensor, the signal containing information regarding at least one container of medicine; a processor configured to determine, from the information, a communication regarding the at least one container of medicine; a network interface configured to transmit the communication; and a user interface configured to provide an indication regarding the at least one container of medicine.

Abstract: An approach to providing predictable and uniform drug delivery across many instances of an automated drug delivery procedure involves measuring features of the drug delivery system prior to delivery. An automated drug delivery procedure is configured to compensate for or otherwise accommodate the impact of these features based on the measured features. In some examples, the measured features are encoded by value or by reference to an external database onto the drug containing component, for example, by affixing a tag (e.g., RFID, barcode, etc.) to the component. At the time of drug delivery, the features are accessed, for example using the affixed tag, and the drug delivery procedure is controlled according to the features.

Abstract: An injector cartridge is configured for sterile storage and transfer of a fluid in a pre-filled syringe. The injector cartridge includes a first housing section and a second housing section and is configured to move the pre-filled syringe from a sterile storage position to a fluid transfer position upon linear displacement of the first housing section relative to the second housing section.

Abstract: An apparatus for transdermal injection includes a collet configured to transition between first and second states. In the first state, the collet receives a cartridge with a predetermined elongate shape. In the second state, an inner surface of the collet substantially conforms to the predetermined elongate shape of the cartridge such that expansion of the cartridge, when the cartridge is pressurized, is substantially uniformly opposed.

Abstract: An apparatus for transdermal injection includes a sleeve including a proximal end, a distal end, and an inner wall surface extending along the sleeve from a first opening at the proximal end to a second opening at the distal end. The inner wall surface forms a channel in the sleeve, the channel having a first portion with a substantially frustoconical shape. The channel of the sleeve is configured to receive a substantially frustconically shaped injection cartridge, to substantially uniformly support the injection cartridge during a transdermal injection operation, and to prevent movement of the injection cartridge out of the distal end of the sleeve.

Abstract: An adapter for use with an injection device includes a first end, a second end and a first longitudinal axis extending from the first end and the second end. The adapter also includes a chamber defined by a sidewall between the first end and second end and a nozzle having a passageway extending through the sidewall, the passageway having an input at the chamber, an output at an outer surface of the body and a passageway axis extending from the input to the output, the passageway axis being angularly offset from the longitudinal axis of the channel. A cartridge can include such an adapter.

Abstract: An apparatus for use in injectate delivery includes an actuator including a linkage, a force generating mechanism mechanically coupled to the linkage, and a controller coupled to the force generating mechanism. The force generating mechanism includes a passive force generator and an active force generator. In operation and on the basis of a control signal, the controller is configured to control the force generating mechanism to provide an input force to the linkage that is a combination of the first force provided by the passive force generator and a second force provided by the active force generator.

Abstract: An injection device for use with a cartridge facilities a transfer of fluid from the cartridge into an injection bore.

Abstract: A needle free injection device for use with a cartridge containing an injectate includes a housing. The housing includes an end wall at its distal end and an inner wall. The inner wall extends in a direction from the proximal end of the housing to the distal end of the housing and separates a first chamber from a second chamber in the housing. The housing includes a first opening disposed in the end wall and is in fluid communication with the first chamber. The housing includes a second opening is in fluid communication with the second chamber. A coupler is disposed in the first chamber for coupling to the cartridge. The first opening and the second opening are in fluid communication via a channel for transfer of fluid between the first chamber and the second chamber.