Patents by Inventor Robert J. Fiel

Robert J. Fiel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5397777
    Abstract: A chelated compound of the formula: ##STR1## where R.sub.1 is independently at each occurrence, R.sub.2, ##STR2## R2 is independently at each occurrence hydrogen, lower alkyl, lower alkyl ester, lower alkyl ether, hydroxy or halogen; A is H, Li, Na, Ca+, Mg+ or Zn+; and Mn is trivalent manganese; provided that, at least two and no more than three R.sub.1 radicals are ##STR3## The compound of the invention is particularly suitable for use in a physiologically compatible composition comprising a physiologically compatible liquid carrier for magnetic resonance imaging. The compound is also suitable as a chelate for removal of manganese from a system.The invention also comprises a method for enhanced magnetic imaging of a mammal organism which comprises introducing the composition at a level of from 20 to 200 mg/Kg of body weight into the circulatory system of the organism; and making a magnetic resonance image of at least a portion of said organism at from 30 minutes to 36 hours after said introduction.
    Type: Grant
    Filed: April 29, 1993
    Date of Patent: March 14, 1995
    Assignee: Health Research, Inc.
    Inventor: Robert J. Fiel
  • Patent number: 5236915
    Abstract: A chelated compound of the formula: ##STR1## where R.sub.1 is independently at each occurrence, ##STR2## R.sub.2 is independently at each occurrence hydrogen, lower alkyl, lower alkyl ester, lower alkyl ether, hydroxy or halogen; A is H, Li, Na, Ca+, Mg+or Zn+; and Mn is trivalent manganese; provided that, at least two and no more than three R.sub.1 radicals are ##STR3## The compound of the invention is particularly suitable for use in a physiologically compatible composition comprising a physiologically compatible liquid carrier for magnetic resonance imaging. The compound is also suitable as a chelate for removal of manganese from a system.The invention also comprises a method for enhanced magnetic imaging of a mammal organism which comprises introducing the composition at a level of from 20 to 200 mg/Kg of body weight into the circulatory system of the organism; and making a magnetic resonance image of at least a portion of said organism at from 30 minutes to 36 hours after said introduction.
    Type: Grant
    Filed: May 31, 1990
    Date of Patent: August 17, 1993
    Assignee: Health Research, Inc.
    Inventor: Robert J. Fiel