Abstract: Disclosed is a sequential operating mechanism for valves for applications requiring actuation of one valve, or set of valves, prior to actuation of another valve, or set of valves. The equipment preferably includes an actuator driver mounted for powered selective reciprocation through a stroke of selected length. The actuator carries cam pins which engage cams (preferably cam slots) on cam plates attached to the stems of the respective valves during the course of an actuator half stroke. The cams are configured with respect to the paths of movement of the cam pins and with respect to the valve stems so that one valve is fully actuated to its extreme position before actuation of the other valve begins. If additional valves, in the same or different piping networks, require actuation at the same time as one or both of the cam actuated valves, such additional valves are ganged for simultaneous operation with the appropriate one of the cam actuated valves.