Patents by Inventor Robert J. Greenhouse

Robert J. Greenhouse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of phospholipid synthesis and methods of use
    Patent number: 11702394
    Abstract: Inhibitors of Glycerol 3-Phosphate Acyltransferase (GPAT) are provided; and methods of use in the treatment of cancer; and treatment of conditions relating to metabolic syndrome and hyperlipidemia.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: July 18, 2023
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Arvin Gouw, Dean W. Felsher, Feng Jin, Richard N. Zare, Katherine Margulis, Steven R. Schow, Robert J. Greenhouse, David Loughhead, Steven Richards
  • INHIBITORS OF PHOSPHOLIPID SYNTHESIS AND METHODS OF USE
    Publication number: 20220315528
    Abstract: Inhibitors of Glycerol 3-Phosphate Acyltransferase (GPAT) are provided; and methods of use in the treatment of cancer; and treatment of conditions relating to metabolic syndrome, hyperlipidemia, infection and inflammation.
    Type: Application
    Filed: August 20, 2020
    Publication date: October 6, 2022
    Inventors: Arvin Gouw, Steven R. Schow, Robert J. Greenhouse, Toni Kline, Dean W. Felsher
  • Reformulating Hospital Gentamicin to reduce the risk of hearing loss while maintaining antimicrobial activity
    Publication number: 20220096509
    Abstract: Reformulations of gentamicin for treatment of infections are provided with the goal to reduce current side effects such as ototoxicity, while maintaining antimicrobial activity. The reformulation is a mixture of three of the C-components of gentamicin: C1a, C2a and C2b, while excluding as much as possible, C1 and C2. Specifically, to the objective of this invention a mixture is formulated having gentamicin C1a ranging from 10-30%, gentamicin C2a ranging from 0-30%, and gentamicin C2b ranging from 40-90%, where the mixture totals a 100% of the gentamicin C-components, defined as C1, C1a, C2, C2a and C2b only. The formulations of this invention increase the probability of a more favorable outcome for the patients exposed to gentamicin, i.e., reduced risk of the side-effect of hearing loss.
    Type: Application
    Filed: February 7, 2020
    Publication date: March 31, 2022
    Inventors: Mary E. O'Sullivan, Anthony J. Ricci, Alan G. Cheng, Robert J. Greenhouse, Markus E. Huth, Randy Lin
  • INHIBITORS OF PHOSPHOLIPID SYNTHESIS AND METHODS OF USE
    Publication number: 20210002240
    Abstract: Inhibitors of Glycerol 3-Phosphate Acyltransferase (GPAT) are provided; and methods of use in the treatment of cancer; and treatment of conditions relating to metabolic syndrome and hyperlipidemia.
    Type: Application
    Filed: February 22, 2019
    Publication date: January 7, 2021
    Inventors: Arvin Gouw, Dean W. Felsher, Feng Jin, Richard N. Zare, Katherine Margulis, Steven R. Schow, Robert J. Greenhouse, David Loughhead, Steven Richards
  • Aminoglycoside Antibiotics with Reduced Ototoxicity
    Publication number: 20160222049
    Abstract: This disclosure relates generally to aminoglycoside derivatives of Formula (I) as described herein. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating bacterial infections by administering these compounds and pharmaceutical compositions to subjects in need thereof.
    Type: Application
    Filed: December 4, 2015
    Publication date: August 4, 2016
    Inventors: Anthony J. Ricci, Robert J. Greenhouse, Alan G. Cheng
  • Aminoglycoside antibiotics with reduced ototoxicity
    Patent number: 9238670
    Abstract: This disclosure relates generally to aminoglycoside derivatives of Formula (I) as described herein. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating bacterial infections by administering these compounds and pharmaceutical compositions to subjects in need thereof.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: January 19, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Anthony J. Ricci, Robert J. Greenhouse, Alan G. Cheng
  • Aminoglycoside Antibiotics with Reduced Ototoxicity
    Publication number: 20140274932
    Abstract: This disclosure relates generally to aminoglycoside derivatives of Formula (I) as described herein. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating bacterial infections by administering these compounds and pharmaceutical compositions to subjects in need thereof.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Inventors: Anthony J. Ricci, Robert J. Greenhouse, Alan G. Cheng
  • 4-monosubstituted and 4,6-disubstituted N-(.alpha.-phenylethyl)phenoxazines
    Patent number: 4803269
    Abstract: 4-Monosubstituted and 4,6-disubstituted phenoxazines, methods of preparing them and pharmaceutical compositions containing them. These compounds are useful as anti-inflammatories.
    Type: Grant
    Filed: August 14, 1987
    Date of Patent: February 7, 1989
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Joseph M. Muchowski, Robert J. Greenhouse, Angel Guzman
  • 4-monosubstituted and 4,6-disubstituted phenoxazines
    Patent number: 4707473
    Abstract: 4-Monosubstitued and 4,6-disubstituted phenoxazines, methods of preparing them and pharmaceutical compositions containing them. These compounds are useful as anti-inflammatories.
    Type: Grant
    Filed: May 30, 1986
    Date of Patent: November 17, 1987
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Joseph M. Muchowski, Robert J. Greenhouse, Angel Guzman
  • 1,2,3-trisubstituted indoles for treatment of inflammation
    Patent number: 4654360
    Abstract: Disclosed are compounds of the formula ##STR1## wherein the several groups are defined herein. These compounds are useful for treating inflammation.
    Type: Grant
    Filed: June 1, 1984
    Date of Patent: March 31, 1987
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Robert J. Greenhouse, Joseph M. Muchowski