Patents by Inventor Robert J. H. Scheffer

Robert J. H. Scheffer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the production of oxazoles by condensing aromatic aldehydes with ?-ketoximes to N-oxides and then reacting the same with activated acid derivatives
    Patent number: 7825144
    Abstract: The invention is related to a process for preparing compounds of the formula IV by means of conversion of aromatic aldehydes of the formula I using ?-ketoximes of the formula II via N-oxides of the formula III to halomethyloxazoles of the formula IV, wherein R1, R2, R3, R4, R5, R6, R7, R8, X1, X2, X3, o, n1 and n2 are as defined herein.
    Type: Grant
    Filed: July 27, 2009
    Date of Patent: November 2, 2010
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Wolfgang Holla, Rolf-Ludwig Hoerlein, Berndt Kulitzscher, Wolfgang Laux, Thomas Stuedemann, Christoph Tappertzhofen, Robert J. H. Scheffer
  • METHOD FOR THE PRODUCTION OF OXAZOLES BY CONDENSING AROMATIC ALDEHYDES WITH a-KETOXIMES TO N-OXIDES AND THEN REACTING THE SAME WITH ACTIVATED ACID DERIVATIVES
    Publication number: 20090286988
    Abstract: The invention is related to a process for preparing compounds of the formula IV by means of conversion of aromatic aldehydes of the formula I using ?-ketoximes of the formula II via N-oxides of the formula III to halomethyloxazoles of the formula IV, wherein R1, R2, R3, R4, R5, R6, R7, R8, X1, X2, X3, o, n1 and n2 are as defined herein.
    Type: Application
    Filed: July 27, 2009
    Publication date: November 19, 2009
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Wolfgang HOLLA, Rolf-Ludwig HOERLEIN, Berndt KULITZSCHER, Wolfgang LAUX, Thomas STUEDEMANN, Christoph TAPPERTZHOFEN, Robert J. H. SCHEFFER
  • Method for the preparation of oxazoles by condensing aromatic aldehydes with ?-ketoximes to form n-oxides and reacting same with activated acid derivatives
    Patent number: 7544809
    Abstract: The present invention is comprised of improved methods in the preparation of oxazoles which results in higher yields with less impurities and contaminants. Oxazoles constitute valuable intermediates in the synthesis of pharmaceutically active substances such as, for example peroxisome proliferator activated receptor (PPAR) agonists which are pharmaceutical actives which can have a positive influence on both lipid and glucose metabolism.
    Type: Grant
    Filed: May 29, 2007
    Date of Patent: June 9, 2009
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Wolfgang Holla, Rolf-Ludwig Hoerlein, Berndt Kulitzscher, Wolfgang Laux, Thomas Stuedemann, Christoph Tappertzhofen, Robert J. H. Scheffer
  • NOVEL INTERMEDIATE COMPOUNDS USEFUL IN THE PREPARATION OF OXAZOLES AND PHARMACEUTICAL ACTIVES FOR THE REGULATION OF LIPID AND GLUCOSE METABOLISM
    Publication number: 20080114035
    Abstract: The present invention is directed to compounds of Formula III wherein the R1-R7 groups or substituents are defined herein. The present invention also comprises improved methods in the preparation of oxazoles in which the compounds of Formula III are intermediates and which results in higher yields with less impurities and contaminants. Oxazoles constitute valuable intermediates in the synthesis of pharmaceutically active substances such as, for example peroxisome proliferator activated receptor (PPAR) agonists which are pharmaceutical actives which can have a positive influence on both lipid and glucose metabolism.
    Type: Application
    Filed: October 30, 2007
    Publication date: May 15, 2008
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Wolfgang HOLLA, Rolf-Ludwig HOERLEIN, Berndt KULITZSCHER, Wolfgang LAUX, Thomas STUEDEMANN, Christoph TAPPERTZHOFEN, Robert J. H. SCHEFFER
  • Process for the preparation of 5- and/or 6-substituted-2-hydroxybenzoic acid esters
    Patent number: 6559336
    Abstract: There is provided a single-step process for the preparation of a compound of formula I. Compounds of formula I are useful as starting materials in the synthesis of natural products and in the manufacture of benzophenone fungicidal agents.
    Type: Grant
    Filed: October 12, 2001
    Date of Patent: May 6, 2003
    Assignee: BASF Aktiengesellschaft
    Inventors: Andreas Pfrengle, Robert J. H. Scheffer, Stefan Scheiblich, Jan Hendrik Wevers, Uwe Josef Vogelbacher, Robert F. Doehner