Patents by Inventor Robert J. Kaiser

Robert J. Kaiser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190225310
    Abstract: An arrangement of fenders nested together for compact storage, the fenders including two or more cylindrical bodies having a cavity accessed through the fender top, the fenders being similar shape but graduated in size such that the cavity of a larger fender tensionally receives the next smaller sized fender, the outer diameter of the smaller fender equal to the inner diameter of the larger fender cavity. A fender has a rigid inner core surrounded by a compressible shell made of foam or similar material. The inner core has attachment points for a rope or line. The smallest nesting fender in the set has a cavity diameter sized to fit a commercially-available, off-the-shelf fender. The fenders may be separated and deployed at individual locations on a vessel, or kept together and deployed as a single fender capable of absorbing a greater impact than any of the fenders individually would absorb.
    Type: Application
    Filed: March 26, 2019
    Publication date: July 25, 2019
    Applicant: Contact Left, LLC
    Inventors: John D. Denney, JR., Eoin J. Dunstan, Robert G. Carrasca, Christopher R. Hamlin, Kathryn Crabb, Dylan Piper-Kaiser
  • Publication number: 20190170373
    Abstract: A heat exchanger system includes a heat exchanger coil, a base of a foam structure including a clamp with a first arm and a second arm, where the first arm and the second arm are configured to exert a clamping force against the heat exchanger coil, and a vertical member of the foam substructure coupled to the base and abutting a cover of the heat exchanger system, where the base and the vertical member are configured to block air flowing through the heat exchanger from flowing into a void between the heat exchanger coil and the cover.
    Type: Application
    Filed: February 4, 2019
    Publication date: June 6, 2019
    Inventors: Robert L. Eskew, Frank D. Ashby, Jeremiah M. Horn, Cody J. Kaiser
  • Publication number: 20120322855
    Abstract: Provided herein are duplex oligonucleotide complexes which can be administered to a cell, tissue or organism to silence a target gene without the aid of a transfection reagent(s). The duplex oligonucleotide complexes of the disclosure include a conjugate moiety that facilitates delivery to a cell, tissue or organism.
    Type: Application
    Filed: July 19, 2012
    Publication date: December 20, 2012
    Applicant: DHARMACON, INC.
    Inventors: Christina Yamada, Anastasia Khvorova, Robert J. Kaiser, Emily Anderson, Devin Leake
  • Patent number: 8026349
    Abstract: Methods and compositions for making nucleoside phosphoramidites and nucleic acids, including mono-, di-, and polynucleotides, comprising a linker covalently attached to a levulinyl moiety are provided. A levulinyl-protected linking moiety affords an orthogonal approach to modifying a polynucleotide during or after solid phase synthesis with a molecule of interest, for example, a conjugate or a dye.
    Type: Grant
    Filed: August 18, 2005
    Date of Patent: September 27, 2011
    Assignee: Dharmacon, Inc.
    Inventors: Stephanie A. Hartsel, Robert J. Kaiser, Michael O. Delaney
  • Patent number: 6870065
    Abstract: A reagent having the general formula of General Formula I: wherein group R is an electrophilic or a nucleophilic moiety suitable for reaction of the reagent with a biologically active species; group R2 is one of H and OH moieties; group R3 is one of an alkyl and a methylene bearing an electronegative substituent; group Z is one of (CH2)n and CH2O(CH2CH2O)n2, and n is an integer of from 1 to 5, and n2 is an integer of from 1 to 4; and each of group Z2 and Z3 are (CH2)CONH(CH2)3CONH(CH2)2. Also, a reagent having the general formula of General Formula II: group R2 is one of H and OH moieties; group Z is one of (CH2)n and CH2O(CH2CH2O)n2, and n is an integer of from 1 to 5, and n2 is an integer of from 1 to 4; each of group Z2 and group Z3 include one of (CH2)CONH(CH2)3CONH(CH2)2; and (CH2)CONH(CH2); and group R is an electrophilic or a nucleophilic moiety suitable for reaction of the reagent with the biologically active species.
    Type: Grant
    Filed: June 28, 2002
    Date of Patent: March 22, 2005
    Assignee: Cambrex Bio Science Rockland, Inc.
    Inventors: Clarence N. Ahlem, Robert J. Kaiser, Kevin P. Lund, Mark L. Stolowitz
  • Patent number: 6818760
    Abstract: This invention provides methods for removing unincorporated dye-labeled molecules from a mixture that includes dye-labeled polynucleotides or other polymers and the unincorporated dye-labeled molecules. The methods involve adsorbing the unincorporated dye-labeled molecules into a plurality of particles that are made up of one or more porous hydrophobic materials that are encapsulated in a hydrophilic matrix.
    Type: Grant
    Filed: October 6, 2000
    Date of Patent: November 16, 2004
    Assignee: Prolinx Incorporated
    Inventors: Douglas A. Spicer, Karin A. Hughes, Robert J. Kaiser, James E. Mahoney, Amy L. Springer, Mark L. Stolowitz, Carl H. D. Weissman
  • Publication number: 20040072203
    Abstract: This invention provides methods for purifying nucleic acids, in particular primer extension products such as those obtained in nucleic acid sequencing reactions. The methods involve the use of a primer to which is attached a string of arylboronic acid moieties. After extension of the primer using a polymerase, the primer extension-products are complexed with a solid support to which is attached an arylboronic acid complexing moiety. The resulting complex is separated from the reaction mixture, washed, and the primer extension products are dissociated from the solid support. The primer extension products are obtained in a form particularly suitable for loading directly on a capillary electrophoresis apparatus.
    Type: Application
    Filed: April 16, 2003
    Publication date: April 15, 2004
    Applicant: Prolinx, Inc.
    Inventors: Connie Kim Dix, Karin A. Hughes, Robert J. Kaiser, Mark L. Stolowitz
  • Publication number: 20040048308
    Abstract: The present invention relates to the cloning of the gene of a thermophilic DNA ligase, from Thermus aquaticus strain HB8, and the use of this ligase in assays for the detection of specific sequences of nucleotides in a variety of nucleic acid samples, and more particularly in those samples containing a DNA sequence characterized by a difference in the nucleic acid sequence from a standard sequence including single nucleic acid base pair changes, deletions, insertions or translocations.
    Type: Application
    Filed: September 12, 2003
    Publication date: March 11, 2004
    Inventors: Francis Barany, John Zebala, Deborah Nickerson, Robert J. Kaiser, Leroy Hood
  • Publication number: 20030105280
    Abstract: A reagent having the general formula of General Formula I: 1
    Type: Application
    Filed: June 28, 2002
    Publication date: June 5, 2003
    Inventors: Clarence N. Ahlem, Robert J. Kaiser, Kevin P. Lund, Mark L. Stolowitz
  • Publication number: 20030003018
    Abstract: Instruments and systems for the analysis of molecular interactions with enhanced throughput and ease-of-use. In certain aspects, the systems and instruments include miniaturized SPR-based sensors and novel sensor surface chemistry to provide high-throughput automated instruments and systems for molecular interaction analysis.
    Type: Application
    Filed: April 2, 2002
    Publication date: January 2, 2003
    Applicant: Prolinx Incorporated
    Inventors: Mark L. Stolowitz, Robert J. Kaiser, Leslie E. Linkkila, Charles E. Dubuque, Michael E. Baum, Erik M. Engstrom, Stephen M. Bailey
  • Patent number: 6414136
    Abstract: This invention provides methods for removing unincorporated fluorescent dye-labeled molecules from a mixture that includes fluorescently-labeled polynucleotides and the unincorporated fluorescent dye-labeled molecules. The methods involve adsorbing the unincorporated fluorescent dye-labeled molecules into a plurality of particles that are made up of one or more porous hydrophobic materials that are encapsulated in a hydrophilic matrix.
    Type: Grant
    Filed: May 3, 2000
    Date of Patent: July 2, 2002
    Assignee: Prolinx, Inc.
    Inventors: Douglas A. Spicer, Karin A. Hughes, Robert J. Kaiser, James E. Mahoney, Amy L. Springer, Mark L. Stolowitz, Carl H. D. Weissman
  • Patent number: 6414122
    Abstract: Embodiments include reagents to modify a bioactive species for incorporating a bifunctional boronic compound complexing moiety for subsequent conjugation to a different or same bioactive species having pendant phenylboronic acid moieties of General Formula I, wherein group R is an electrophilic or nucleophilic moiety suitable for reaction of the putative bifunctional boronic compound complexing reagent with a bioactive species, wherein group R2 is selected from one of H and OH moieties, and wherein group R3 is selected from one of an alkyl and a methylene bearing an electronegative substituent. Group Z is a spacer selected from (CH2)n and CH2O(CH2CH2O)n2, wherein n is an integer of from 1 to 5, and wherein n2 is an integer of from 1 to 4. Group Z2 and Z3 is a spacer and need not be the same.
    Type: Grant
    Filed: August 29, 2000
    Date of Patent: July 2, 2002
    Assignee: Prolinx, Inc.
    Inventors: Clarence N. Ahlem, Robert J. Kaiser, Kevin P. Lund, Mark L. Stolowitz
  • Publication number: 20010049438
    Abstract: This invention provides methods for purifying nucleic acids, in particular primer extension products such as those obtained in nucleic acid sequencing reactions. The methods involve the use of a primer to which is attached a string of arylboronic acid moieties. After extension of the primer using a polymerase, the primer extension products are complexed with a solid support to which is attached an arylboronic acid complexing moiety. The resulting complex is separated from the reaction mixture, washed, and the primer extension products are dissociated from the solid support. The primer extension products are obtained in a form particularly suitable for loading directly on a capillary electrophoresis apparatus.
    Type: Application
    Filed: July 8, 1999
    Publication date: December 6, 2001
    Inventors: CONNIE KIM DIX, KARIN A. HUGHES, ROBERT J. KAISER, MARK L. STOLOWITZ
  • Patent number: 6156884
    Abstract: Reagents suitable for the modification of a bioactive species for the purpose of incorporating a bifunctional boronic compound complexing moiety for subsequent conjugation to a different (or the same) bioactive species having pendant phenylboronic acid moieties of General Formula 1, ##STR1## wherein group R is an electrophilic or nucleophilic moiety suitable for reaction of the putative bifunctional boronic compound complexing reagent with a bioactive species, wherein group R.sub.2 is selected from one of H and OH moieties, and wherein group R.sub.3 is selected from one of an alkyl and a methylene bearing an electronegative substituent. Group Z is a spacer selected from (CH.sub.2).sub.n and CH.sub.2 O(CH.sub.2 CH.sub.2 O).sub.n.sbsb.2, wherein n is an integer of from 1 to 5, and wherein n.sub.2 is an integer of from 1 to 4. Each of group Z.sub.2 and Z.sub.3 is a spacer selected from CH.sub.2 Ar, CH.sub.2 CONHCH.sub.2 Ar, CH.sub.2 CONH(CH.sub.2).sub.n.sbsb.3 CO--NHCH.sub.2 Ar, and (CH.sub.2).sub.n.sbsb.
    Type: Grant
    Filed: December 29, 1998
    Date of Patent: December 5, 2000
    Assignee: Prolinx, Inc.
    Inventors: Clarence N. Ahlem, Robert J. Kaiser, Kevin P. Lund, Mark L. Stolowitz
  • Patent number: 6054564
    Abstract: The present invention relates to the cloning of the gene of a thermophilic DNA ligase, from Thermus aquaticus strain HB8, and the use of this ligase for the detection of specific sequences of nucleotides in a variety of nucleic acid samples, and more particularly in those samples containing a DNA sequence characterized by a difference in the nucleic acid sequence from a standard sequence including single nucleic acid base pair changes, deletions, insertions or translocations.
    Type: Grant
    Filed: October 7, 1997
    Date of Patent: April 25, 2000
    Assignees: Cornell Research Foundation, Inc., California Institute of Technology
    Inventors: Francis Barany, John Zebala, Deborah Nickerson, Robert J. Kaiser, Jr., Leroy Hood
  • Patent number: 6031117
    Abstract: The present invention provides arylboronic acid reagents useful for incorporation into modified oligonucleotides and polynucleotides. The modified oligonucleotides and polynucleotides thus produced are useful in bioconjugation reactions for the immobilization and purification of macromolecules.
    Type: Grant
    Filed: March 19, 1999
    Date of Patent: February 29, 2000
    Assignee: Prolinx Incorporated
    Inventors: Robert J. Kaiser, Mark L. Stolowitz
  • Patent number: 6013783
    Abstract: The present invention relates to the field of nucleic acid immobilization, purification and detection and, more particularly, to boronic acid modified oligonucleotides and polynucleotides useful in bioconjugation reactions. The modified oligonucleotides and polynucleotides are useful in reactions for the immobilization and purification of macromolecules.
    Type: Grant
    Filed: March 19, 1999
    Date of Patent: January 11, 2000
    Assignee: Prolinx Incorporated
    Inventors: Robert J. Kaiser, Mark L. Stolowitz
  • Patent number: 5876938
    Abstract: Modified nucleotides and polynucleotides which are useful in hybridization assays for the detection of target genes are provided. The modified polynucleotides contain at least one boronic acid moiety which is attached to a nucleotide base in a position which does not interfere with the hydrogen bonding capabilities of that base during duplex formation. The modified polynucleotides are typically formed from naturally occurring nucleotides and one or more modified nucleotides.
    Type: Grant
    Filed: April 11, 1997
    Date of Patent: March 2, 1999
    Assignee: Prolinx, Incorporated
    Inventors: Mark L. Stolowitz, Robert J. Kaiser
  • Patent number: 5877297
    Abstract: Boron compound completing reagents, intermediate reagents of those reagents and methods of synthesizing these reagents. These reagents, including those shown as General Formula CII may be used, after further reactions described herein, to complex with boronic compounds, such as phenylboronic acid or derivatives thereof. ##STR1## In one embodiment, group Z comprises a spacer selected from a saturated or unsaturated chain up to about 0 to 6 carbon equivalents in length, an unbranched saturated or unsaturated chain of from about 6 to 18 carbon equivalents in length with at least one of intermediate amide and disulfide moieties, and a polyethylene glycol chain of from 3 to 12 carbon equivalents in length; group R.sub.2 is one of an alkyl and a methylene with an electronegative moiety; and BAS is a biologically active species.
    Type: Grant
    Filed: October 22, 1997
    Date of Patent: March 2, 1999
    Assignee: Prolinx, Inc.
    Inventors: Mark L. Stowolitz, Robert J. Kaiser, Kevin P. Lund
  • Patent number: 5872224
    Abstract: Boron compound complexing reagents, boron compound complexes, and methods of synthesizing these reagents and complexes are disclosed. These reagents and complexes include those shown in General Formula CIV, and General Formula CVI. In one embodiment, the reagent of General Formula CIV may be used to form a complex with a boron compound, such as a complex shown in General Formula CVI. ##STR1## In one embodiment, group Z comprises a spacer selected from a saturated or unsaturated chain of up to about 6 carbon equivalents in length, an unbranched saturated or unsaturated chain of from about 6 to 18 carbon equivalents in length with at least one of intermediate amide and disulfide moieties, and a polyethylene glycol chain of from about 3 to 12 carbon equivalents in length; group R.sub.3 is selected from one of an H, an alkyl, and a methylene or ethylene moiety with an electronegative substituent; and BAS and BAS* are biologically active species.
    Type: Grant
    Filed: October 22, 1997
    Date of Patent: February 16, 1999
    Assignee: Prolinx, Inc.
    Inventors: Mark L. Stolowitz, Robert J. Kaiser, Kevin P. Lund