Patents by Inventor Robert J. Kaiser, Jr.

Robert J. Kaiser, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thermostable ligase mediated DNA amplification system for the detection of genetic diseases
    Patent number: 6054564
    Abstract: The present invention relates to the cloning of the gene of a thermophilic DNA ligase, from Thermus aquaticus strain HB8, and the use of this ligase for the detection of specific sequences of nucleotides in a variety of nucleic acid samples, and more particularly in those samples containing a DNA sequence characterized by a difference in the nucleic acid sequence from a standard sequence including single nucleic acid base pair changes, deletions, insertions or translocations.
    Type: Grant
    Filed: October 7, 1997
    Date of Patent: April 25, 2000
    Assignees: Cornell Research Foundation, Inc., California Institute of Technology
    Inventors: Francis Barany, John Zebala, Deborah Nickerson, Robert J. Kaiser, Jr., Leroy Hood
  • Thermostable ligase mediated DNA amplification system for the detection of genetic diseases
    Patent number: 5830711
    Abstract: The present invention relates to the cloning of the gene of a thermophilic DNA ligase, from Thermus aquaticus strain HB8, and the use of this ligase for the detection of specific sequences of nucleotides in a variety of nucleic acid samples, and more particularly in those samples containing a DNA sequence characterized by a difference in the nucleic acid sequence from a standard sequence including single nucleic acid base pair changes, deletions, insertions or translocations.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: November 3, 1998
    Assignees: Cornell Research Foundation, Inc., California Institute of Technology
    Inventors: Francis Barany, John Zebala, Deborah Nickerson, Robert J. Kaiser, Jr., Leroy Hood
  • Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
    Patent number: 5494810
    Abstract: The present invention relates to the cloning of the gene of a thermophilic DNA ligase, from Thermus aquaticus strain HB8, and the use of this ligase in a ligase chain reaction (LCR) assay for the detection of specific sequences of nucleotides in a variety of nucleic acid samples, and more particularly in those samples containing a DNA sequence characterized by a difference in the nucleic acid sequence from a standard sequence including single nucleic acid base pair changes, deletions, insertions or translocations.
    Type: Grant
    Filed: November 22, 1994
    Date of Patent: February 27, 1996
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Francis Barany, John Zebala, Deborah Nickerson, Robert J. Kaiser, Jr., Leroy Hood
  • Oligonucleotides possessing a primary amino group in the terminal nucleotide
    Patent number: 5118800
    Abstract: The invention consists of compounds and methods for the synthesis of oligonucleotides which contain one or more free aliphatic amino groups attached to the sugar moieties of the nucleoside subunits. The synthetic method is versatile and general, permitting amino groups to be selectively placed at any position on oligonucleotides of any composition or length which is attainable by current DNA synthetic methods. Fluorescent dyes or other detectable moieties may be covalently attached to the amino groups to yield the corresponding modified oligonucleotide.
    Type: Grant
    Filed: February 27, 1991
    Date of Patent: June 2, 1992
    Assignee: California Institute of Technology
    Inventors: Lloyd M. Smith, Steven Fung, Robert J. Kaiser, Jr.
  • DNA-reporter conjugates linked via the 2' or 5'-primary amino group of the 5'-terminal nucleoside
    Patent number: 5118802
    Abstract: The invention consists of compounds and methods for the synthesis of oligonucleotides which contain one or more free aliphatic amino groups attached to the sugar moieties of the nucleoside subunits. The synthetic method is versatile and general, permitting amino groups to be selectively placed at any position on oligonucleotides of any composition or length which is attainable by current DNA synthetic methods. Fluorescent dyes or other detectable moieties may be covalently attached to the amino groups to yield the corresponding modified oligonucleotide.
    Type: Grant
    Filed: February 27, 1991
    Date of Patent: June 2, 1992
    Assignee: California Institute of Technology
    Inventors: Lloyd M. Smith, Steven Fung, Robert J. Kaiser, Jr.
  • Nucleosides possessing blocked aliphatic amino groups
    Patent number: 5015733
    Abstract: The invention consists of compounds and methods for the synthesis of oligonucleotides which contain one or more free aliphatic amino groups attached to the sugar moieties of the nucleoside subunits. The synthetic method is versatile and general, permitting amino groups to be selectively placed at any position on oligonucleotides of any composition or length which is attainable by current DNA synthetic methods. Fluorescent dyes or other detectable moieites may be covalently attached to the amino groups to yield the corresponding modified oligonucleotide.
    Type: Grant
    Filed: December 19, 1988
    Date of Patent: May 14, 1991
    Assignee: California Institute of Technology
    Inventors: Lloyd M. Smith, Steven Fund, Robert J. Kaiser, Jr.