Patents by Inventor Robert J. Lederman
Robert J. Lederman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10575851Abstract: This disclosure relates to devices and methods for manipulating, such as with a suction based traction device, a target anatomic structure inside the body and delivering an ligation device around the anatomic structure. In particular examples, the target structure can be an atrial appendage, and the devices and methods are for atrial appendage ligation.Type: GrantFiled: October 27, 2014Date of Patent: March 3, 2020Assignee: The United States of America, as Represented by the the Secretary, Department of Health and Human ServicesInventors: Toby Rogers, Kaniska Ratnayaka, Ozgur Kocaturk, Robert J. Lederman
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Patent number: 10463495Abstract: Delivery devices for delivering encircling implants can include two separate limbs that are held together at a distal articulation by the implant being delivered. The implant can comprise a suture and/or a braided tube. The implant can extend through or over the limbs. The implant and at least a distal portion of the limbs can be compressible into a delivery shape that allows for advancement through the lumen of a delivery catheter. When the distal portion of the limbs move out of the delivery catheter, the limbs and implant can resiliently assume a loop shape that is complementary to a shape of a target around which the encircling implant is to be placed. The limbs are then retracted from along the implant to leave the implant in the desired delivery position. The delivery device can be used to place encircling implants around the heart or other targets, and the implant can be tightened to exert compressive force on the target.Type: GrantFiled: June 3, 2014Date of Patent: November 5, 2019Assignee: The United States of America, as Represented by the Secretary, Department of Health and Human ServicesInventors: Toby Rogers, Robert J. Lederman, Merdim Sonmez, Dominique N. Franson, Ozgur Kocaturk
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Publication number: 20190321043Abstract: In some implementations, a radially self-expanding endograft prosthesis is provided that includes (i) distal flange that is self-expanding and configured to flip generally perpendicularly with respect to a body of the prosthesis to help seat the prosthesis against a tissue wall, (ii) a distal segment extending proximally from the distal flange that has sufficient stiffness to maintain a puncture open that is formed through a vessel wall (iii) a compliant middle segment extending proximally from the distal segment, the middle segment being more compliant than the distal segment, and having independently movable undulating strut rings attached to a tubular fabric, the combined structure providing flexibility and compliance to allow for full patency while flexed, the segment being configured to accommodate up to a 90 degree bend, (iv) a proximal segment having a plurality of adjacent undulating strut rings that are connected to each other.Type: ApplicationFiled: April 30, 2019Publication date: October 24, 2019Inventors: Nasser Rafiee, Stuart MacDonald, Robert J. Lederman, Kanishka Ratnayaka, Biwei MacDonald, Alana Rafiee
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Patent number: 10433962Abstract: Devices and methods are disclosed for the treatment or repair of regurgitant cardiac valves, such as a mitral valve. An illustrative annuloplasty device can be placed in the coronary sinus to reshape the mitral valve and reduce mitral valve regurgitation. An improved protective device can be placed between the annuloplasty device and an underlying coronary artery to inhibit compression of the underlying coronary artery by the annuloplasty device in the coronary sinus. In addition, the protective device can inhibit compression of the coronary artery from inside the heart, such as from a prosthetic mitral valve that exerts radially outward pressure toward the coronary artery. The annuloplasty device can also create an artificial inner ridge or retaining feature projecting into the native mitral valve region to help secure a prosthetic mitral valve.Type: GrantFiled: October 27, 2017Date of Patent: October 8, 2019Assignees: Transmural Systems LLC, The United States of America, as Represented by the Secretary, Department of Health and Human ServicesInventors: Nasser Rafiee, Stuart MacDonald, Koosha Rafiee, Rany Busold, Robert J. Lederman, Toby Rogers
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Patent number: 10426482Abstract: In some implementations, a radially self-expanding endograft prosthesis is provided that includes (i) distal flange that is self-expanding and configured to flip generally perpendicularly with respect to a body of the prosthesis to help seat the prosthesis against a tissue wall, (ii) a distal segment extending proximally from the distal flange that has sufficient stiffness to maintain a puncture open that is formed through a vessel wall (iii) a compliant middle segment extending proximally from the distal segment, the middle segment being more compliant than the distal segment, and having independently movable undulating strut rings attached to a tubular fabric, the combined structure providing flexibility and compliance to allow for full patency while flexed, the segment being configured to accommodate up to a 90 degree bend, (iv) a proximal segment having a plurality of adjacent undulating strut rings that are connected to each other.Type: GrantFiled: September 15, 2016Date of Patent: October 1, 2019Assignees: The United States of America, as Represented by the Secretary, Department of Health and Human Services, Transmural Systems LLCInventors: Nasser Rafiee, Stuart MacDonald, Robert J. Lederman, Kanishka Ratnayaka, Biwei MacDonald, Alana Rafiee
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Patent number: 10376253Abstract: Transcatheter methods are disclosed for introducing a large transcatheter implant or other device into an artery from an adjacent vein, for example from the inferior vena cava into the abdominal aorta. Such an access route can be formed by direct puncture through the adjoining vessels. In addition, methods and devices are also disclosed for closing arteriovenous fistulas or other cardiovascular passageways.Type: GrantFiled: November 27, 2013Date of Patent: August 13, 2019Assignee: THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human servicesInventors: Robert J. Lederman, Ozgur Kocaturk
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Publication number: 20180353163Abstract: The present disclosure provides a variety of prostheses, delivery systems and techniques to facilitate closure of transvascular or transcameral access ports. Various embodiments of prostheses are provided including a plurality of radially expandable discs that can be filled with material to facilitate coagulation and to reduce or stop leakage from punctures in vessel walls.Type: ApplicationFiled: July 31, 2018Publication date: December 13, 2018Inventors: Nasser Rafiee, Stuart MacDonald, Robert J. Lederman, Toby Rogers, Rany Busold, Koosha Rafiee
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Publication number: 20180289482Abstract: Devices and methods are disclosed for the treatment or repair of regurgitant cardiac valves, such as a mitral valve. An annuloplasty device can be placed in the coronary sinus to reshape the mitral valve and reduce mitral valve regurgitation. A protective device can be placed between the annuloplasty device and an underlying coronary artery to inhibit compression of the underlying coronary artery by the annuloplasty device in the coronary sinus. In addition, the protective device can inhibit compression of the coronary artery from inside the heart, such as from a prosthetic mitral valve that exerts radially outward pressure toward the coronary artery. The annuloplasty device can also create an artificial inner ridge or retaining feature projecting into the native mitral valve region to help secure a prosthetic mitral valve.Type: ApplicationFiled: April 16, 2018Publication date: October 11, 2018Inventors: June-Hong Kim, Robert J. Lederman, Ozgur Kocaturk
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Publication number: 20180280006Abstract: Disclosed herein are devices and methods for closing a hole in the wall of a cardiovascular structure from the inside using a self-assembling closure device. The closure device can be delivered to the subject hole from the inside of the cardiovascular chamber using a transcatheter approach. Disclosed techniques involve deploying the closure device from the delivery device such that an endo-cameral portion of the closure device self-expands first to cover the hole from the inside, and then extra-cameral arms of the device are released to self-deploy against the outside of the wall by withdrawal of a retaining element, such as a guidewire, to secure the closure device to the wall.Type: ApplicationFiled: September 30, 2016Publication date: October 4, 2018Applicant: The United States of America, as represented by the Secretary, Department of Health and HumanInventors: Toby Rogers, Merdim Sonmez, Ozgur Kocaturk, Robert J. Lederman
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Publication number: 20180243530Abstract: Disclosed herein are segmented MRI-compatible interventional devices, such as catheters and guidewires, that provide desired mechanical properties while avoiding undesired interactions with MRI fields. Disclosed devices can include helical wires with insulated breaks at intervals along each wire so that the insulated wire segments are individually short enough to avoid substantial resonance and heat being generated in the wires due to an applied MRI field. The segmented wires can be organized into a braided/woven tubular configuration or a non-braided intercalated/parallel tubular configuration that provides the desired mechanical properties similar to conventional metallic braided catheters. The helical wire segments can be insulated such that the wires do not touch each other at points where they cross over each other.Type: ApplicationFiled: September 14, 2016Publication date: August 30, 2018Applicants: Human ServicesInventors: Robert J. Lederman, Ozgur Kocaturk
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Patent number: 10058315Abstract: The present disclosure provides a variety of prostheses, delivery systems and techniques to facilitate closure of transvascular or transcameral access ports. Various embodiments of prostheses are provided including a plurality of radially expandable mesh discs filled with material to facilitate coagulation and to reduce or stop leakage from punctures in vessel walls.Type: GrantFiled: September 27, 2016Date of Patent: August 28, 2018Assignees: Transmural Systems LLC, The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Nasser Rafiee, Stuart MacDonald, Robert J. Lederman, Toby Rogers, Rany Busold, Koosha Rafiee
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Patent number: 10045765Abstract: The present disclosure provides a variety of prostheses, delivery systems and techniques to facilitate closure of transvascular or transcameral access ports. Various embodiments of prostheses are provided including a plurality of radially expandable discs that can be filled with material to facilitate coagulation and to reduce or stop leakage from punctures in vessel walls.Type: GrantFiled: July 31, 2017Date of Patent: August 14, 2018Assignees: Transmural Systems LLC, The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Nasser Rafiee, Stuart MacDonald, Robert J. Lederman, Toby Rogers, Rany Busold, Koosha Rafiee
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Publication number: 20180214667Abstract: Disclosed delivery catheters have a three-dimensional curvature that facilitates reaching the RAA from the inferior vena cava, positioning the distal end of the catheter generally parallel to the plane of the pericardial space at the puncture location within the RAA, orienting the puncturing device in a direction that avoids the right coronary artery, aorta, pulmonary artery, and other structures to prevent bystander injury to such structures, and provides sufficient rigidity to puncture through a wall of the RAA into the pericardial space.Type: ApplicationFiled: May 9, 2016Publication date: August 2, 2018Applicants: The United States of America, as represented by the Secretary, Department of Health and Human, Henry Ford Health SystemInventors: Robert J. Lederman, Toby Rogers, Nasser Rafiee, Adam B. Greenbaum, William W. O'Neill
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Patent number: 9987135Abstract: Disclosed here are devices and methods for treating functional tricuspid valve regurgitation and related conditions. Disclosed devices are adapted for applying force to an area of a patient's heart along or near the atrioventricular groove, and can include a tensioning element configured to be delivered by a flexible member guided through a catheter and positioned generally along or near the atrioventricular groove, and a compression member positionable along the tensioning element and over a desired segment of the atrioventricular groove to develop force to be applied to an adjacent area of the heart by selective tensioning of the tensioning element.Type: GrantFiled: March 13, 2014Date of Patent: June 5, 2018Assignee: The United States of America, as Represented by the Secretary, Department of Health and Human ServicesInventors: Robert J. Lederman, Kanishka Ratnayaka, Toby Rogers
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Patent number: 9943409Abstract: Devices and methods are disclosed for the treatment or repair of regurgitant cardiac valves, such as a mitral valve. An annuloplasty device can be placed in the coronary sinus to reshape the mitral valve and reduce mitral valve regurgitation. A protective device can be placed between the annuloplasty device and an underlying coronary artery to inhibit compression of the underlying coronary artery by the annuloplasty device in the coronary sinus. In addition, the protective device can inhibit compression of the coronary artery from inside the heart, such as from a prosthetic mitral valve that exerts radially outward pressure toward the coronary artery. The annuloplasty device can also create an artificial inner ridge or retaining feature projecting into the native mitral valve region to help secure a prosthetic mitral valve.Type: GrantFiled: February 29, 2016Date of Patent: April 17, 2018Assignee: The United States of America, as Represented by the Secretary, Department of Health and Human ServicesInventors: June-Hong Kim, Robert J. Lederman, Ozgur Kocaturk
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Publication number: 20180098850Abstract: Devices and methods are disclosed for the treatment or repair of regurgitant cardiac valves, such as a mitral valve. An illustrative annuloplasty device can be placed in the coronary sinus to reshape the mitral valve and reduce mitral valve regurgitation. An improved protective device can be placed between the annuloplasty device and an underlying coronary artery to inhibit compression of the underlying coronary artery by the annuloplasty device in the coronary sinus. In addition, the protective device can inhibit compression of the coronary artery from inside the heart, such as from a prosthetic mitral valve that exerts radially outward pressure toward the coronary artery. The annuloplasty device can also create an artificial inner ridge or retaining feature projecting into the native mitral valve region to help secure a prosthetic mitral valve.Type: ApplicationFiled: October 27, 2017Publication date: April 12, 2018Inventors: Nasser Rafiee, Stuart MacDonald, Koosha Rafiee, Rany Busold, Robert J. Lederman, Rogers Toby
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Publication number: 20180008248Abstract: The present disclosure provides a variety of prostheses, delivery systems and techniques to facilitate closure of transvascular or transcameral access ports. Various embodiments of prostheses are provided including a plurality of radially expandable discs that can be filled with material to facilitate coagulation and to reduce or stop leakage from punctures in vessel walls.Type: ApplicationFiled: July 31, 2017Publication date: January 11, 2018Inventors: Nasser Rafiee, Stuart MacDonald, Robert J. Lederman, Toby Rogers, Rany Busold, Koosha Rafiee
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Publication number: 20170239450Abstract: Disclosed herein are embodiments of segmented metallic guidewires that are suitable for MRI catheterization. Disclosed guidewires comprise a plurality of short conductive metallic segments that individually are short enough such that they do not resonate during MRI. The conductive segments are electrically insulated from each other and mechanically coupled together end-to-end via connectors, such as stiffness matched connectors, to provide a sufficiently long, strong, and flexible guidewire for catheterization that is non-resonant during MRI.Type: ApplicationFiled: October 19, 2015Publication date: August 24, 2017Applicant: The United States of America, as represented by the Secretary, Department of Health and Human ServInventors: Ozgur KOCATURK, Burcu BASAR, Robert J. LEDERMAN
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Publication number: 20170224488Abstract: Devices, apparatus, and methods for catheter-based repair of cardiac valves, including transcatheter-mitral-valve-cerclage annuloplasty and transcatheter-mitral-valve reapposition. In particular, a target and capture device is provided for guiding a cerclage traversal catheter system through a cerclage trajectory, particularly through a reentry site of the cerclage trajectory. The target and capture device provides the user with a target through which the cerclage traversal catheter system must be guided, particularly under imaging guidance, so as to properly traverse the cerclage trajectory at any desired location, particularly at a reentry site. The target and capture device can, further, ensnare and externalize the cerclage traversal catheter system.Type: ApplicationFiled: February 25, 2017Publication date: August 10, 2017Inventors: Robert J. Lederman, Ozgur Kocaturk
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Publication number: 20170071722Abstract: In some implementations, a radially self-expanding endograft prosthesis is provided that includes (i) distal flange that is self-expanding and configured to flip generally perpendicularly with respect to a body of the prosthesis to help seat the prosthesis against a tissue wall, (ii) a distal segment extending proximally from the distal flange that has sufficient stiffness to maintain a puncture open that is formed through a vessel wall (iii) a compliant middle segment extending proximally from the distal segment, the middle segment being more compliant than the distal segment, and having independently movable undulating strut rings attached to a tubular fabric, the combined structure providing flexibility and compliance to allow for full patency while flexed, the segment being configured to accommodate up to a 90 degree bend, (iv) a proximal segment having a plurality of adjacent undulating strut rings that are connected to each other.Type: ApplicationFiled: September 15, 2016Publication date: March 16, 2017Inventors: Nasser RAFIEE, Stuart MACDONALD, Robert J. LEDERMAN, Kanishka RATNAYAKA, Biwei MACDONALD, Alana RAFIEE