Patents by Inventor Robert J. Mandle

Robert J. Mandle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4678553
    Abstract: A process is disclosed for recovering renatured polypeptides and proteins (collectively "polypeptides") from solution thereof and/or of their S-sulfonate derivatives (collectively "solution of polypeptides") in denaturants comprising:introducing said solution into a renaturant chamber (compartment, cell, space) of an electrodialysis ("ED") apparatus, said chamber bounded by membranes each of which is substantially permeable to low molecular weight singly charged ions of at least one charge sign and substantially impermeable to said polypeptides and S-sulfonate derivatives, said membranes separating said renaturant chamber from juxtaposed rinsing chambers on each side of the renaturant chamber;introducing rinsing solutions into said juxtaposed rinsing chambers, said rinsing solutions synergetically with said membranes facilitating a decrease in the chaotropism of said denaturant in said renaturant chamber when a direct electric current is imposed through said renaturant and rinsing chambers in series;applying
    Type: Grant
    Filed: July 11, 1986
    Date of Patent: July 7, 1987
    Assignee: Ionics, Incorporated
    Inventors: Robert J. Mandle, Wayne A. McRae
  • Patent number: 4673483
    Abstract: The disclosure is directed to an improved apparatus and method for isoelectric focusing whereby the reservoirs and recirculating paths in the apparatus are sealed off from the atmosphere. A liquid is employed which contains buffering compounds capable of maintaining a pH gradient in an electric field. A plurality of permeable diaphragms or membranes are used to separate the flows of liquid while allowing interchange of liquid constituents therebetween. A direct current electrical potential is established transverse to the flow, so as to maintain a gradient of pH steps as between successive channels defined by the membranes, and to separate a mixture of amphoteric substances into said channels.
    Type: Grant
    Filed: March 20, 1986
    Date of Patent: June 16, 1987
    Assignee: Ionics Incorporated
    Inventor: Robert J. Mandle
  • Patent number: 4661224
    Abstract: Processes and apparatuses are described for recovering components dispersed in an aqueous solution comprising contacting said solution as a first solution with an electrically conducting barrier, diaphragm or membrane which has a high affinity for at least one of said components whereby a substantial fraction of said component is sorbed by said barrier. The barrier is subsequently contacted with a second aqueous solution and a direct electric current is passed through said barrier and second solution in a direction substantially parallel to the smallest dimension of the barrier thereby facilitating desorption of at least one of the sorbed components from the barrier into the second solution which solution is thereafter removed.
    Type: Grant
    Filed: April 11, 1986
    Date of Patent: April 28, 1987
    Assignee: Ionics, Incorporated
    Inventors: Arthur L. Goldstein, Edgar Haber, Robert J. Mandle
  • Patent number: 4584075
    Abstract: Processes and apparatuses are described for recovering components dispersed in an aqueous solution comprising contacting said solution as a first solution with an electrically conducting barrier, diaphragm or membrane which has a high affinity for at least one of said components whereby a substantial fraction of said component is sorbed by said barrier. The barrier is subsequently contacted with a second aqueous solution and a direct electric current is passed through said barrier and second solution in a direction substantially parallel to the smallest dimension of the barrier thereby facilitating desorption of at least one of the sorbed components from the barrier into the second solution which solution is thereafter removed.
    Type: Grant
    Filed: November 26, 1984
    Date of Patent: April 22, 1986
    Assignee: Ionics Incorporated
    Inventors: Arthur L. Goldstein, Edgar Haber, Robert J. Mandle